Electrochemical N-acylation and N-α-ketoacylation of sulfoximines via the selective decarboxylation and dehydration of α-ketoacids
Green Chemistry,
Год журнала:
2023,
Номер
25(21), С. 8838 - 8844
Опубликована: Янв. 1, 2023
We
describe
an
electrochemical
N
-acylation
and
-α-ketoacylation
of
sulfoximines
via
the
selective
decarboxylation
dehydration
α-ketoacids
using
electricity
as
a
“traceless”
oxidant
α-ketoacid
“acyl”
or
“α-ketoacyl”
source.
Язык: Английский
Recent Advances in the Catalytic Synthesis of α‐Ketoamides
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
α
‐Ketoamides
are
privileged
chemical
entities
featuring
a
carbonyl
group
bonded
to
an
amide.
Bearing
two
pronucleophilic
and
proelectrophilic
sites,
this
structural
scaffold
exhibits
distinct
properties
unparalleled
biological
activity.
Owing
its
wide
application
in
medicinal,
agricultural,
synthetic
chemistry,
methods
for
assembling
moiety
ever‐growing
demand.
With
the
increasing
focus
on
green
synthesis,
traditional
routes
‐ketoamides
have
faded
recent
years
giving
rise
development
of
photocatalytic,
electrosynthetic,
microwave‐assisted
catalytic
protocols.
We
hereby
provide
comprehensive
critical
summary
all
advancements
witnessed
field
from
2016
present.
Язык: Английский
Construction of α‐ketoamides via Photoredox‐Catalyzed N−H Insertion of Amines by Sulfoxonium Ylides
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Abstract
Herein,
we
report
the
development
of
photoredox‐catalyzed
N−H
insertion
sulfoxonium
ylides
with
amines
via
oxidative
single‐electron
transfer
(SET).
These
reactions
exhibit
broad
substrate
scope
(32
examples)
and
offer
operationally
simple,
scalable
procedures
for
accessing
α
‐ketoamides
in
a
single
step.
Mechanistic
studies
control
experiments
confirm
participation
photogenerated
carbon
radical
facilitating
(SET)
from
to
initiate
reaction.
Язык: Английский