Dual Roles of Supporting Electrolytes in Organic Electrosynthesis

ChemElectroChem, Год журнала: 2024, Номер 11(8)

Опубликована: Янв. 18, 2024

Abstract Synthetic electro‐organic chemistry is advancing to a well‐established methodology in academic research and industry. The simple process control minimizes reagent waste avoids using toxic environmentally unfriendly redox agents, providing feasible sustainable alternative conventional techniques. However, fundamental disadvantage, the necessity of ion‐conductive components within electrolyte. recovery these supporting electrolytes, as well product isolation, pose challenges for work‐up strategies. This review presents following electrochemical protocols featuring material‐ resource‐saving strategy: dual role electrolytes conductivity enabling reagents or meditators. first conclude categorize strategies electrolytes. It may inspire electrochemists advance development optimization synthesis towards more resource‐efficient reaction control.

Язык: Английский

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Revisiting the Electrochemical Reduction Mechanism of Nitrosobenzene in Acetonitrile. Concomitant Reactions and Voltammetric Simulation

ChemElectroChem, Год журнала: 2024, Номер 11(3)

Опубликована: Янв. 4, 2024

Abstract The electrochemical reduction mechanism of nitrosobenzene in acetonitrile was reconsidered this work. commonly accepted assumes that the radical anion dimerize to yield a dianion, which decompose into azoxybenzene as product. Even though proposal is consistent with preparative experiments, it does not reproduce fully experimental voltammetric behaviour when simulated. Also, It explain why apparent electron number different time scale cyclic voltammetry and electrolysis. To understand these discrepancies, proposed intervention reactions consuming part starting nitrosobenzene, allowed reconsider role alternative chemical like occurring between phenylhydroxylamine hydroxyl ion nitrosobenzene. In framework, concomitant were additionally included simulate at scan rates. Thermodynamic kinetic parameters extended are reported. Since either product or reactive some reaction steps, global deemed occurs kind loop.

Язык: Английский

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Challenges and opportunities on sustainable electrochemical transformations: application towards the synthesis of pharmaceuticals and precursors of drug-like molecules

Green Chemistry, Год журнала: 2024, Номер 26(10), С. 5770 - 5789

Опубликована: Янв. 1, 2024

This article highlighted the recent demand for sustainable and resource efficient drug synthesis using electrochemical strategies.

Язык: Английский

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Novel pyrazoline and pyrazole “turn on” fluorescent sensors selective for Zn²⁺/Cd²⁺ at λ_em 480 nm and Fe³⁺/Fe²⁺ at λ_em 465 nm in MeCN

RSC Advances, Год журнала: 2024, Номер 14(5), С. 3519 - 3524

Опубликована: Янв. 1, 2024

A small series of simple pyrazoline and pyrazole based sensors, all derived from the same chalcone precursors, were synthesised, characterised screened for their fluorescence “turn on” properties in presence multiple metals.

Язык: Английский

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MOF-253·Cu(OAc)2 as a heterogeneous catalyst for N-arylation of heterocycles

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123641 - 123641

Опубликована: Март 1, 2025

Язык: Английский

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Singlet molecular oxygen generated from trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolan-3-yl ethaneperoxate-mediated oxidative aromatization of 1,3,5-trisubstituted 2-pyrazolines

Monatshefte für Chemie - Chemical Monthly, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

Язык: Английский

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Biphasic Electrosynthesis of 2-Isoxazol(in)e-3-carboxylates: Reaction Optimization from Milligram to Hectogram Scale

ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер 12(30), С. 11369 - 11376

Опубликована: Июль 15, 2024

An electrochemical synthesis of isoxazol(in)e-3-carboxylates in a biphasic system allowing the direct access to technically relevant motifs good yields has been established. The versatility this protocol was demonstrated by >30 highly functionalized and diverse examples. Furthermore, derivative isoxadifen-ethyl synthesized more sustainable approach, avoiding hazardous reagents generation large amounts waste. A nitrile oxide as key intermediate is formed without addition strong bases or oxidizers directly undergoes desired cycloaddition. technical relevance established method underlined hectogram-scale while purifying crude product simple silica filtration. By distillation, nonconverted styrene largely recovered, demonstrating sustainability method.

Язык: Английский

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Iodine‐Catalyzed Carbonyl‐Alkyne Metathesis Reactions

Chemistry - A European Journal, Год журнала: 2024, Номер 30(61)

Опубликована: Июль 22, 2024

Abstract The reaction between aldehydes or ketones and alkynes—the carbonyl‐alkyne metathesis—constitutes a very useful strategy for the synthesis of α,β‐unsaturated carbonyls. We now demonstrate that iodine is highly efficient catalyst both intra‐ intermolecular metathesis in small concentrations (0.1–1 mol %). Our protocol outperforms other catalytic systems, operationally simple, cheap, metal‐free, tolerates large variety functional groups (e. g., −CN, −CO 2 Me, −Br, −OH) at low loadings. can furthermore show iodine‐catalyzed metatheses be combined with reactions one‐pot procedures to afford larger more complex molecular structures. Finally, our mechanistic studies indicate iodonium ion active under conditions.

Язык: Английский

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Electrochemical Heterocyclic Ring-Formation Reactions by Making C–N and N–N Bonds

Topics in heterocyclic chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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Five-membered ring systems: With more than 1 N atom

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 211 - 257

Опубликована: Янв. 1, 2024

Язык: Английский

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