Ethers as Building Blocks for the Synthesis and Modification of N‐Heterocycles DOI
Sergei Y. Grishin, Olga M. Mulina, Leiyang Lv

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 16, 2024

Abstract The use of C−H compounds as reactive partners in a variety transformations represents the state art synthetic methodology. In this review, we have summarized main achievements using ethers building blocks for construction and modification one basic platforms organic chemistry, nitrogen‐containing heterocycles. Ethers, previously considered mainly solvents, are excellent CH‐partners, capable generating radical or cationic species under action HAT agents oxidants. challenge field is still limited number heterocyclic systems other starting reagents, with which processes can be carried out selectively due to closer bond dissociation energies oxidation potentials heterocycles, intermediates ethers. However, fine‐tuning reaction system electro‐ photochemical approaches deep understanding pathways make reagents promising strategy.

Язык: Английский

Construction of 1,4-Dihydropyridines: The Evolution of C4 Source DOI
Siyu Song, Yongchao Wang, Fuchao Yu

и другие.

Topics in Current Chemistry, Год журнала: 2023, Номер 381(5)

Опубликована: Сен. 25, 2023

Язык: Английский

Процитировано

7
NBS-Promoted Synthesis of Thiocyanated Aminomaleimides and Site-Selective Intramolecular Cyclization Access to 1,4-Benzothiazepines via S–CN Bond Cleavage DOI
Qi Yang,

Shuntao Huang,

Lu Yin

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(8), С. 5266 - 5276

Опубликована: Апрель 9, 2024

A transition metal-free concise and efficient protocol for the synthesis of thiocyanated aminomaleimides benzo[e][1,4]thiazepine derivatives has been developed. The method involves an initial α-C–H thiocyanation with KSCN TEMPO-mediated tandem S–CN bond cleavage/intramolecular cyclization substitution processes, which enables formation seven-membered S/N-heterocycles. This synthetic strategy provides a reliable biologically interesting by using as sulfur sources well expands application enaminones reactions in heterocycles synthesis.

Язык: Английский

Процитировано

1
DBU‐Promoted Solvent‐Free One‐Pot Multicomponent Synthesis of 2‐Amino‐1,4‐Dihydropyridines From β‐Enaminones, Aromatic Aldehydes and Malononitrile DOI

Saikrishna Chintha,

Nagaraju Medishetti,

Maneesha Karangi

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(28)

Опубликована: Июль 23, 2024

Abstract The synthesis of 2‐amino‐1,4‐dihydropyridines was accomplished starting from β‐enaminones, aromatic aldehydes and malononitrile with DBU without solvent. reaction proceeds through a Knoevenegel condensation, which affords the benzylidine olefin intermediate. This can directly react β‐enaminone, leading to desired product. Simple conditions no solvent good yields are advantages this protocol.

Язык: Английский

Процитировано

0
Ethers as Building Blocks for the Synthesis and Modification of N‐Heterocycles DOI
Sergei Y. Grishin, Olga M. Mulina, Leiyang Lv

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 16, 2024

Abstract The use of C−H compounds as reactive partners in a variety transformations represents the state art synthetic methodology. In this review, we have summarized main achievements using ethers building blocks for construction and modification one basic platforms organic chemistry, nitrogen‐containing heterocycles. Ethers, previously considered mainly solvents, are excellent CH‐partners, capable generating radical or cationic species under action HAT agents oxidants. challenge field is still limited number heterocyclic systems other starting reagents, with which processes can be carried out selectively due to closer bond dissociation energies oxidation potentials heterocycles, intermediates ethers. However, fine‐tuning reaction system electro‐ photochemical approaches deep understanding pathways make reagents promising strategy.

Язык: Английский

Процитировано

0