On the way to potential antifungal compounds: synthesis and in vitro activity of 2-benzofuranylacetic acid amides DOI Creative Commons
Camilo Mahecha‐Mahecha, Paola Borrego-Muñoz, Luis M. Pombo

и другие.

RSC Advances, Год журнала: 2023, Номер 13(36), С. 25296 - 25304

Опубликована: Янв. 1, 2023

Crop losses caused by microbial infections are a significant global issue, especially in tropical regions. The development of novel antimicrobial agents, particularly antifungal has been explored from various perspectives, including chemical synthesis. However, conventional approaches typically involve synthesizing new and potent compounds on small scale (a few milligrams), making the scale-up reaction major challenge. In this manuscript, we present method for synthesis active (against Fusarium oxysporum) benzofuranyl acetic acid amides. Our strategy allows us to synthesize key precursor gram scale, enabling production sufficient quantities other within short timeframes conducting biological studies. All reactions used manuscript recognized their industrial application.

Язык: Английский

Diazo Quinone: An Effective Phenolic Precursor for Building C(sp2)−C(sp2) Bonds DOI Creative Commons
Kai Wu, Chi‐Ming Che

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(5)

Опубликована: Фев. 23, 2024

Abstract Phenolic biaryl and styryl moieties are important structural motifs in natural products, pharmaceuticals, functional materials. Traditional cross‐coupling often requires pre‐functional substrates is accompanied by generation of organometallic by‐products. In recent years, diazo quinone has become a new type high‐efficiency phenolic coupling reagent for the preparation compounds. This because it can be used to construct C(sp 2 )−C(sp ) bonds an environment‐friendly (transition‐metal‐free) or more direct way. this review, we focus on advances field transition‐metal‐free reactions quinones with organoboranes transition‐metal catalyzed quinoid carbene )−H arylation reactions.

Язык: Английский

Процитировано

5
Gold(I)‐Catalyzed Synthesis of Benzofurans from Tetrahydropyranyl (THP) Ethers of o‐Alkynylphenols DOI

Jeremy W. Pisor,

Isabella Garcia, Kirubel Mamo

и другие.

Chemistry - An Asian Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract The activation of π‐systems in alkenes and alkynes by homogeneous gold catalysts is a powerful tool for the synthesis benzo‐fused heterocycles. Decades development area catalysis have brought an array new with them discovery modes carbophilic alkynes, investigations previously unknown mechanistic pathways. In alignment these efforts, we report cyclization tetrahydropyranyl ethers 2‐alkynylphenols to form benzofurans catalyzed gold(I)–NHC complex. reaction proceeds efficiently at very low catalyst loadings, products good yields.

Язык: Английский

Процитировано

0
On the way to potential antifungal compounds: synthesis and in vitro activity of 2-benzofuranylacetic acid amides DOI Creative Commons
Camilo Mahecha‐Mahecha, Paola Borrego-Muñoz, Luis M. Pombo

и другие.

RSC Advances, Год журнала: 2023, Номер 13(36), С. 25296 - 25304

Опубликована: Янв. 1, 2023

Crop losses caused by microbial infections are a significant global issue, especially in tropical regions. The development of novel antimicrobial agents, particularly antifungal has been explored from various perspectives, including chemical synthesis. However, conventional approaches typically involve synthesizing new and potent compounds on small scale (a few milligrams), making the scale-up reaction major challenge. In this manuscript, we present method for synthesis active (against Fusarium oxysporum) benzofuranyl acetic acid amides. Our strategy allows us to synthesize key precursor gram scale, enabling production sufficient quantities other within short timeframes conducting biological studies. All reactions used manuscript recognized their industrial application.

Язык: Английский

Процитировано

2