One pot multicomponent reaction of curcumin: Green synthesis of novel 1,4‐dihydropyridine‐2,3‐dicarboxylates
Journal of Heterocyclic Chemistry,
Год журнала:
2024,
Номер
61(8), С. 1306 - 1313
Опубликована: Июнь 12, 2024
Abstract
In
this
research,
investigation
of
one‐pot
multicomponent
reactions
(1E,6E)‐1,7‐bis(4‐hydroxy‐3‐methoxyphenyl)hepta‐1,6‐diene‐3,5‐dione
(curcumin),
primary
amines,
and
activated
acetylenic
compounds
in
an
aqueous
medium
at
room
temperature
the
presence
catalytic
amounts
silica‐coated
magnetic
nanoparticles
functionalized
by
iminodiacetic
acid‐copper
(Fe
3
O
4
@SiO
2
/IDA‐Cu)
was
studied
which
produced
1,4‐dihydropyridine‐2,3‐dicarboxylate
high
yields.
The
advantages
procedure
were
easy
separation
products
catalyst,
yields
products,
reusability
synthesized
good
rate
reactions.
Язык: Английский
Synthesis of new Michael acceptors with cinnamamide scaffold as potential anti-breast cancer agents: cytotoxicity and ADME in silico studies
Medicinal Chemistry Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Язык: Английский
Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by 19F-MRI
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(29), С. 5948 - 5959
Опубликована: Янв. 1, 2024
Novel
curcumin
derivatives
with
a
higher
number
of
19
F
nuclei
which
exhibited
high
binding
affinity
to
Aβ
oligomers
for
diagnosis
Alzheimer’s
disease
by
F-MRI.
Язык: Английский
Diastereoselective synthesis of highly substituted cyclohexanones and tetrahydrochromene-4-ones via conjugate addition of curcumins to arylidenemalonates
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 2016 - 2023
Опубликована: Авг. 15, 2024
A
cascade
inter-intramolecular
double
Michael
strategy
for
the
synthesis
of
highly
functionalized
cyclohexanones
from
curcumins
and
arylidenemalonates
is
reported.
This
works
in
presence
aqueous
KOH
using
TBAB
as
a
suitable
phase
transfer
catalyst
at
room
temperature.
The
are
formed
major
products
moderate
to
excellent
yields
with
complete
diastereoselectivity
most
cases.
triple
adduct,
tetrahydrochromen-4-one,
also
side
product
few
cases
diastereoselectivity.
Язык: Английский