Photoredox-Catalyzed C-Indolyl/Quinolyl Glycosylation from 2-Styrylisocyanides and Glycosyl Bromides

Organic Letters, Год журнала: 2024, Номер 26(38), С. 8149 - 8153

Опубликована: Сен. 16, 2024

Indole and quinoline structures are present in numerous biologically active molecules, making the synthesis of their glycosylation products a subject extensive research interest drug development. Here, we report photoredox strategy for

Язык: Английский

FeF₃‐Promoted Radical Fluoroalkylation of o‐Alkenylaryl Isocyanides to Access 2‐Fluoroalkylated Quinolines

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(30)

Опубликована: Апрель 24, 2024

Abstract An iron(III)‐promoted radical fluoroalkylation of o‐alkenylaryl isocyanides has been developed using readily available perfluoroalkyl iodides as fluoroalkyl source. This cyclization reaction features broad substrate scope and provides a simple efficient approach for regioselective construction biologically important 2‐fluoroalkylated quinolines in 38–81 % yields.

Язык: Английский

A New Method of Constructing Methyleneindene and Quinoline Frameworks from Methylenecyclopropanes

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(15)

Опубликована: Май 9, 2024

In this paper, we have established an operationally convenient protocol for the rapid construction of polysubstituted methyleneindene and quinoline derivatives under mild conditions. This new synthetic method is achieved through conversion acetyl-substituted methylenecyclopropanes with TsOH ⋅ H

Язык: Английский