Development of a mucoadhesive drug delivery system and its interaction with gastric cells
Beilstein Journal of Nanotechnology,
Год журнала:
2025,
Номер
16, С. 371 - 384
Опубликована: Март 13, 2025
Drugs
that
are
designed
for
local
treatment
of
gastric
diseases
require
increased
residence
time
prolonged
action
and
efficacy.
In
this
study,
we
report
a
mucoadhesive
drug
delivery
system
was
developed
to
fulfill
these
requirements.
Alginate
nanoparticles
were
synthesized
by
water-in-oil
emulsification
followed
external
gelation
then
coated
with
the
polymer
Eudragit
RS100.
The
formulated
had
mean
size
219
nm
positive
charge.
A
peptide,
as
model
drug,
loaded
onto
an
encapsulation
efficiency
58%.
release
from
pH-independent
lasted
7
days.
periodic
acid–Schiff
stain
assay
indicated
69%
mucin
interaction
nanoparticles,
which
also
capable
diffusion
through
artificial
mucus.
not
toxic
epithelial
cells
can
be
internalized
within
4
h.
adsorption
mucus-secreting
found
correlated
cell
number.
in
study
is
intended
active
therapeutic
agents
has
potential
used
alternative
strategy
related
diseases.
Язык: Английский
The mucosal protein corona in local nanoparticle drug delivery
Опубликована: Март 1, 2025
Recent advances in the application of polymeric nanoparticles to the pulmonary delivery of mRNA
Peyton M. Panovich,
A. Ganesan,
Amogh R. Angadi
и другие.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Май 30, 2025
Messenger
RNA
(mRNA)-based
therapeutics
offer
the
potential
to
treat
a
variety
of
pulmonary
disorders
that
arise
due
genetics,
infectious
diseases,
and
chronic
respiratory
conditions.
However,
various
physiological
barriers
in
lungs,
such
as
mucociliary
clearance,
macrophage
phagocytosis,
lung
surfactant
interference,
present
challenges
for
efficient
mRNA
delivery.
Polymeric
nanoparticles
(NPs)
have
emerged
therapeutic
platform
delivering
their
stability,
tunability,
controlled
release
properties,
making
them
suitable
potentially
ideal
encapsulating
protecting
molecules
delivery
vivo.
Continued
advances
polymer
NP
design
improved
mucus
penetration
cellular
uptake
upon
delivery;
further,
administration
via
local
systemic
routes
enable
modulation
biodistribution.
These
advancements
benefit
treatment
range
including
viral
infections,
cystic
fibrosis
(CF),
asthma,
cancer,
by
facilitating
immune
genetic
therapy
In
this
review,
we
explore
how
polymeric
NPs
address
disease-specific
requirements
expand
mRNAs
lung.
Язык: Английский