Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(4)
Опубликована: Июль 1, 2024
Polymer-drug
conjugates
and
polymer-protein
have
been
pivotal
in
the
realm
of
drug
delivery
systems
for
over
half
a
century.
These
polymeric
drugs
are
characterized
by
conjugation
therapeutic
molecules
or
functional
moieties
to
polymers,
enabling
range
benefits
including
extended
circulation
times,
targeted
delivery,
controlled
release,
decreased
immunogenicity.
This
review
delves
into
recent
advancements
challenges
clinical
translations
preclinical
studies
polymer-drug
conjugates.
The
design
principles
functionalization
strategies
crucial
development
these
were
explored
followed
structural
properties
characteristics
various
polymer
carriers.
also
identifies
significant
obstacles
translation
provides
insights
directions
their
future
development.
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease.
Язык: Английский
Hydroxyapatite–polymer nanocomposites for drug delivery applications: A mini review
European Journal of Medicinal Chemistry Reports,
Год журнала:
2024,
Номер
unknown, С. 100231 - 100231
Опубликована: Окт. 1, 2024
Язык: Английский
Clinical Applications of Targeted Nanomaterials
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 379 - 379
Опубликована: Март 17, 2025
Targeted
nanomaterials
are
at
the
forefront
of
advancements
in
nanomedicine
due
to
their
unique
and
versatile
properties.
These
include
nanoscale
size,
shape,
surface
chemistry,
mechanical
flexibility,
fluorescence,
optical
behavior,
magnetic
electronic
characteristics,
as
well
biocompatibility
biodegradability.
attributes
enable
application
across
diverse
fields,
including
drug
delivery.
This
review
explores
fundamental
characteristics
emphasizes
importance
clinical
applications.
It
further
delves
into
methodologies
for
nanoparticle
programming
alongside
discussions
on
trials
case
studies.
We
discussed
some
promising
nanomaterials,
such
polymeric
nanoparticles,
carbon-based
metallic
role
biomedical
underscores
significant
translating
applications
highlights
potential
these
innovative
approaches
revolutionizing
medical
field.
Язык: Английский
Synthesis and Evaluation of Polymer-Drug Conjugates as Potential Antioxidants and Cholinesterase Inhibitors for Neurodegenerative Diseases
Chemistry of Materials,
Год журнала:
2024,
Номер
36(21), С. 10514 - 10527
Опубликована: Окт. 23, 2024
Polymer-drug
conjugates
(PDCs)
may
offer
improved
water-solubility
and
in
vitro
activity
of
potential
antioxidant
cholinesterase
(ChE)
inhibitor
drugs
compared
to
the
alone.
Conjugation
these
water-soluble
polymers
could
increase
their
therapeutic
efficacy.
Vanillin
was
conjugated
poly(allylamine
hydrochloride)
(NM10
NM15)
naphthalimidohexylamine
(HEXNAP)
poly(acrylic
acid)
(N5
N10).
The
inhibitory
activities
novel
PDCs
were
evaluated
with
those
respective
starting
materials.
Additionally,
silico
molecular
modeling
studies
conducted
explore
mechanisms
conjugates.
NM15
(unadjusted
adjusted
value)
showed
significantly
enhanced
(p
≤
0.0001)
vanillin.
value
N5
HEXNAP
against
acetylcholinesterase
(AChE)
butyrylcholinesterase
(BuChE)
0.0001).
Kinetic
revealed
that
a
competitive
interacted
active
sites
human
enzymes.
identified
as
lead
based
on
activity,
respectively.
Overall,
this
work
demonstrates
use
treatment
options
for
neurodegenerative
diseases.
Язык: Английский