Overview of Phenylhydrazine‐Based Organic Transformations DOI Open Access
Pragati Kushwaha,

Ayush Bhardwaj,

Rashi

и другие.

ChemistrySelect, Год журнала: 2024, Номер 10(1)

Опубликована: Дек. 30, 2024

Abstract Phenylhydrazines, comprised of a phenyl group attached with hydrazine unit, contribute potentially to organic synthetic transformations. Because the myriad applications, last decade has witnessed considerable upsurge interest perform various reactions catalyzed/mediated/promoted by phenylhydrazines. Some these have shown high regioselectivity in short reaction time under mild conditions. The emergence innumerable transformations utilizing phenylhydrazine unleashed numerous openings for development diverse heterocyclic scaffolds. Given importance this valuable chemical entity, review highlights methodologies Moreover, present article will considerably synthesis as well pharmaceutical chemistry. Academically, be interesting and informative researchers attempting develop new routes structures.

Язык: Английский

Cu-Catalyzed Synthesis of Symmetric Diarylamines from Organoboronic Acids Using NaNO2 as the Amino Source DOI
Daming Liu,

Hui You,

Shuo Zhang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

A copper-catalyzed novel synthesis of symmetric diarylamines was achieved from aryl boronic acids and NaNO2. This protocol employs as the commercially available arylation reagents sodium nitrite (NaNO2) cheap, stable, solid amino source. Under a simple ligand- base-free copper catalytic system (CuCl sole catalyst), wide range could be obtained in moderate to good yields. Notably, use Na15NO2 produce 15N-labeled diarylamines, which would otherwise difficult prepare by known methods.

Язык: Английский

Процитировано

0

Easy Access to α,β-Diamino-Substituted Cyclopentenaminones through Copper-Catalyzed Double Amination of Unactivated Cyclic Ketones DOI
Yihan Wang, Xiao‐Juan Yang, Zhiying Zhang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Here, we report a copper-catalyzed double amination of unactivated cyclic ketones with commercially available secondary arylamines for the synthesis α,β-diamino-substituted cyclopentenaminones. The direct intermolecular C-N bond formation reaction offers advantages using an inexpensive copper catalyst, high atom and step economy, mild conditions, convenient operation. Mechanistic experiments indicate that this α,β-difunctionalization proceeds through oxidative α-enamination/desaturation ketone one arylamine molecule to form α-enaminone intermediate, followed by another molecule.

Язык: Английский

Процитировано

0

Tosylhydrazide-Induced 1,6-Enyne Radical Cyclization under Copper Catalysis: Access to 3,4-Dihydronaphthalen-1(2H)-one Derivatives DOI

Yeganeh Sadat Hosseini Nasab,

Saideh Rajai‐Daryasarei,

Frank Röminger

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

We describe an approach to access 4-aroyl-3-aryl-3,4-dihydronaphthalen-1(2H)-one derivatives in 41–79% yields through the Cu-catalyzed radical cyclization/desulfonylation of 1,6-enynes with tosylhydrazide under air conditions. This alternative desulfonylation strategy combines mild conditions, external oxidant-free processes, and sustainability, contributing more environmentally friendly organic synthesis. The mechanistic studies showed that CuCl/O2 combination serves as source oxygen atom needed form C═O bond. existence is crucial for this conversion.

Язык: Английский

Процитировано

1

N-Hydroxyphthalimides as Nitrogen Radical Precursors in the Copper-Catalyzed Radical Cross-Coupling Amination of Arylboronic Acids: Synthesis of Arylamines DOI

Hafiz Noor,

Shuwei Zhang, Xiaodong Jia

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

A new and practical approach for the synthesis of arylamines via copper-catalyzed radical cross-coupling amination arylboronic acids has been developed. The key enabling advance in this protocol is design

Язык: Английский

Процитировано

1

Overview of Phenylhydrazine‐Based Organic Transformations DOI Open Access
Pragati Kushwaha,

Ayush Bhardwaj,

Rashi

и другие.

ChemistrySelect, Год журнала: 2024, Номер 10(1)

Опубликована: Дек. 30, 2024

Abstract Phenylhydrazines, comprised of a phenyl group attached with hydrazine unit, contribute potentially to organic synthetic transformations. Because the myriad applications, last decade has witnessed considerable upsurge interest perform various reactions catalyzed/mediated/promoted by phenylhydrazines. Some these have shown high regioselectivity in short reaction time under mild conditions. The emergence innumerable transformations utilizing phenylhydrazine unleashed numerous openings for development diverse heterocyclic scaffolds. Given importance this valuable chemical entity, review highlights methodologies Moreover, present article will considerably synthesis as well pharmaceutical chemistry. Academically, be interesting and informative researchers attempting develop new routes structures.

Язык: Английский

Процитировано

0