Organophotocatalyzed C‐Si Bond Fragmentation Using Silyl Ethers as Radical Precursors

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(19), С. 4132 - 4138

Опубликована: Июль 19, 2024

Abstract In this work, silyl ethers of phenols and alcohols have been successfully prepared tested as neutral carbon (silicon) centered radical precursors. The organophotocatalyzed oxidation (by the Fukuzumi catalyst) these caused cleavage a C−Si (or Si−Si) bond for release desired to be used forging C( sp 3 ) −C( −Si) bonds via Giese reaction.

Язык: Английский

Automated One‐pot Library Synthesis with Aldehydes as Radical Precursors

Chemistry - Methods, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract The increased demand for the synthesis of Csp 3 enriched motifs and urgency discovering new drugs requires development more efficient technologies synthetic tools to accelerate drug discovery processes. Herein, we report a fully automated strategy addition building blocks onto olefins via Giese forge −Csp bonds. developed protocol allowed in‐situ conversion aldehydes (non‐redox‐active species) electroactive imidazolidines their use as precursors C‐centered radicals under photoredox catalyzed conditions bioactive compound libraries by synthesizing sp ‐enriched compounds.

Язык: Английский