Synthesis of Bridged Bicyclic Systems peri‐Annulated to the Indole Ring: Tropane‐Fused Indoles
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(12), С. 2784 - 2790
Опубликована: Апрель 23, 2024
Abstract
Ytterbium
triflate
catalysed
domino
reaction
of
(3‐formyl‐4‐indolyl)‐derived
donor‐acceptor
cyclopropane
with
primary
amines
provides
a
simple
approach
to
an
unprecedented
tetracyclic
skeleton
in
which
tropane
system
is
peri
‐annulated
indole
core.
This
process
involves
the
formation
imine
and
its
(3+2)‐cross‐cycloaddition
moiety,
yielding
tropane‐fused
core
under
mild
conditions.
These
products
are
significant
interest
for
pharmacology
as
potential
hybrid
molecules
dual
mode
action.
Язык: Английский
1,3-Difunctionalization of Donor–Acceptor Cyclopropanes Enabled by Copper Nitrate: A Direct Approach to γ-Halonitrates
Organic Letters,
Год журнала:
2024,
Номер
26(45), С. 9659 - 9664
Опубликована: Окт. 31, 2024
1,3-Difunctionalization
of
donor–acceptor
cyclopropanes
with
copper
nitrate
and
N-halosuccinimide
was
developed
to
efficiently
afford
γ-halonitrates.
The
pivotal
factor
this
protocol
lies
in
the
dual
role
as
a
Lewis
acid
an
ideal
nitrooxy
source.
given
approach
features
easy
handling,
good
functional
group
compatibility,
wide
substrate
scope.
Furthermore,
various
transformations
obtained
γ-chloronitrates
underscore
remarkable
synthetic
potential
inherent
method.
Язык: Английский