1,3-Difunctionalization of Donor–Acceptor Cyclopropanes Enabled by Copper Nitrate: A Direct Approach to γ-Halonitrates DOI

Ruoxin Huang,

Mingchun Gao,

Zhenkun Yang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(45), С. 9659 - 9664

Опубликована: Окт. 31, 2024

1,3-Difunctionalization of donor–acceptor cyclopropanes with copper nitrate and N-halosuccinimide was developed to efficiently afford γ-halonitrates. The pivotal factor this protocol lies in the dual role as a Lewis acid an ideal nitrooxy source. given approach features easy handling, good functional group compatibility, wide substrate scope. Furthermore, various transformations obtained γ-chloronitrates underscore remarkable synthetic potential inherent method.

Язык: Английский

Synthesis of Bridged Bicyclic Systems peri‐Annulated to the Indole Ring: Tropane‐Fused Indoles DOI

Sergey M. Antropov,

Sofiya A. Tokmacheva,

Ирина И. Левина

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(12), С. 2784 - 2790

Опубликована: Апрель 23, 2024

Abstract Ytterbium triflate catalysed domino reaction of (3‐formyl‐4‐indolyl)‐derived donor‐acceptor cyclopropane with primary amines provides a simple approach to an unprecedented tetracyclic skeleton in which tropane system is peri ‐annulated indole core. This process involves the formation imine and its (3+2)‐cross‐cycloaddition moiety, yielding tropane‐fused core under mild conditions. These products are significant interest for pharmacology as potential hybrid molecules dual mode action.

Язык: Английский

Процитировано

5

1,3-Difunctionalization of Donor–Acceptor Cyclopropanes Enabled by Copper Nitrate: A Direct Approach to γ-Halonitrates DOI

Ruoxin Huang,

Mingchun Gao,

Zhenkun Yang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(45), С. 9659 - 9664

Опубликована: Окт. 31, 2024

1,3-Difunctionalization of donor–acceptor cyclopropanes with copper nitrate and N-halosuccinimide was developed to efficiently afford γ-halonitrates. The pivotal factor this protocol lies in the dual role as a Lewis acid an ideal nitrooxy source. given approach features easy handling, good functional group compatibility, wide substrate scope. Furthermore, various transformations obtained γ-chloronitrates underscore remarkable synthetic potential inherent method.

Язык: Английский

Процитировано

0