Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 379 - 379
Опубликована: Март 17, 2025
Targeted
nanomaterials
are
at
the
forefront
of
advancements
in
nanomedicine
due
to
their
unique
and
versatile
properties.
These
include
nanoscale
size,
shape,
surface
chemistry,
mechanical
flexibility,
fluorescence,
optical
behavior,
magnetic
electronic
characteristics,
as
well
biocompatibility
biodegradability.
attributes
enable
application
across
diverse
fields,
including
drug
delivery.
This
review
explores
fundamental
characteristics
emphasizes
importance
clinical
applications.
It
further
delves
into
methodologies
for
nanoparticle
programming
alongside
discussions
on
trials
case
studies.
We
discussed
some
promising
nanomaterials,
such
polymeric
nanoparticles,
carbon-based
metallic
role
biomedical
underscores
significant
translating
applications
highlights
potential
these
innovative
approaches
revolutionizing
medical
field.
Folic
acid
(FA)
residue
is
a
well-known
and
widely
spread
targeting
ligand,
or
biovector,
used
as
component
in
engineering
artificial
nanosized
submicron
particles
(NSPs)
to
target
various
cells
treat
variety
of
diseases
that
are
associated
with
FA
(or
folate)
receptors
(FR)
overexpression.
A
particular
place
the
list
these
held
by
cancer
types,
for
which
overexpression
FR
on
cell
surface
often
accompanied
more
severe
disease
course,
increased
resistance
conventional
chemotherapy,
poorer
prognosis.
The
incorporation
albumin
into
NSPs
has
been
shown
enhance
their
biocompatibility,
give
high
compatibility
drug
molecules,
prolong
circulation,
reduce
thrombogenic
activity,
improve
colloidal
stability.
Nowadays
albumin-based
agent
photothermal
photodynamic
therapy,
combined
visualization,
theranostics
(also
known
theragnostics)
types
cancer:
breast,
cervical,
ovarian,
prostate,
nasopharyngeal,
gastric,
colorectal,
liver
cancer,
brain
tumors.
limited
number
studies
have
also
focused
use
rheumatoid
arthritis
treatment.
In
this
review,
we
discuss
ways
FA-albumin
conjugation
albumin-modified
systems.
An
application
delivery
systems
base
serum
therapy
diagnostics
discussed.
Phytochemicals,
the
bioactive
compounds
derived
from
plants,
play
a
significant
role
in
modulating
pathways
leading
to
cancer
and
inflammation,
rendering
themselves
promising
candidates
for
therapeutic
interventions.
This
review
explores
multifaceted
potential
of
various
phytochemicals
key
mechanisms
involved
development
progression
inflammation.
The
diverse
array
discussed
here
encompasses
polyphenols,
flavonoids,
alkaloids,
terpenoids,
many
others,
each
with
distinct
molecular
targets
modes
action.
is
an
attempt
elucidate
correlate
regulatory
on
cellular
signaling
implicated
oncogenesis
inflammatory
responses,
highlighting
significance
phytochemical-based
therapies
prevention
treatment,
as
well
managing
conditions.
By
exploring
remedies
prevention,
conditions
emphasizing
their
roles
critical
mechanisms,
this
addresses
current
research
landscape,
challenges,
future
directions
utilizing
effective
agents
against
