Unveiling the trending paradigms of synthesis and theranostic biomedical potentials of nano-diamonds (NDs)
Inorganic Chemistry Communications,
Год журнала:
2025,
Номер
unknown, С. 114313 - 114313
Опубликована: Март 1, 2025
Язык: Английский
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Metastasis
is
the
leading
cause
of
death
in
patients
with
lung
cancer.
Multidisciplinary
comprehensive
treatments
(MDT),
including
surgery,
chemotherapy,
radiotherapy,
gene-targeted
therapy,
immunotherapy,
antibody-drug
conjugate
(ADC),
natural
products,
etc.,
have
been
currently
used
for
cancer
metastasis.
The
MDT
model
has
shown
promising
efficacy
against
metastasis
clinical
practice.
However,
these
therapies
some
limitations,
such
as
unusual
toxic
side
effects,
drug
resistance,
limited
indications,
and
high
costs.
Therefore,
emerging
technological
platforms
are
imperative
to
overcome
bottlenecks.
Nanomedicine
can
be
prepare
efficient
delivery
systems
owing
its
good
biocompatibility,
targeting,
responsive
release,
multidrug
codelivery
plays
an
important
role
synergistic
antimetastasis
because
optical,
acoustic,
electrical,
thermal,
magnetic
functions.
This
review
analyses
limitations
model,
briefly
outlines
advantages
nanotechnology,
introduces
nanodrug
systems,
summarizes
nanostrategies
based
on
invasion-metastasis
cascade
process,
provides
a
summary
prospects
challenges
translation
nanomedicines.
Язык: Английский
Cell Death Mechanisms Produced by Carbon‐Based Nanoparticles
Journal of Nanotechnology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Using
carbon‐based
nanoparticles,
such
as
diamond,
graphite,
fullerene,
and
nanotubes,
has
increased
their
research
possible
strategies
for
drug
delivery
to
control
diseases,
especially
cancer.
However,
because
these
materials,
when
interacting
with
the
living
environment,
release
substances
that
are
capable
of
inducing
cell
death
by
themselves,
it
is
vital
importance
analyze
type
particle
can
induce.
Although
there
different
efforts
describe
kind
nanoparticles
used
treat
diseases
cancer,
no
paper
explains
mechanisms
induced
nanoparticle
systems.
Therefore,
this
attempts
gain
cutting‐edge
information
on
using
nanopolymorphisms
mechanism
particles
produce.
In
conclusion,
carbon
interact
directly
membranes,
causing
physical
damage
disturbing
integrity
membrane.
This
alteration
mainly
lead
necrosis
or
apoptosis.
The
definition
a
predominant
each
depends
dose‐dependent
manner.
Primarily,
concentrations
cytotoxicity
were
100–500
μg/mL.
several
studies
analyzed,
was
only
find
nanodiamonds
proved
not
be
cytotoxic.
Язык: Английский
Self-supply of hydrogen peroxide by a bimetal-based nanocatalytic platform to enhance chemodynamic therapy for tumor treatment
Nanotechnology,
Год журнала:
2024,
Номер
36(4), С. 045101 - 045101
Опубликована: Окт. 30, 2024
Abstract
The
tumor
microenvironment
(TME)
is
characterized
by
low
pH,
hypoxia,
and
overexpression
of
glutathione
(GSH).
Owing
to
the
complexity
pathogenesis
heterogeneity
TME,
achieving
satisfactory
efficacy
with
a
single
treatment
method
difficult,
which
significantly
impedes
treatment.
In
this
study,
composite
nanoparticles
calcium-copper/alginate-hyaluronic
acid
(HA)
(CaO
2
-CuO
@SA/HA
NC)
pH
GSH
responsiveness
were
prepared
for
first
time
through
one-step
synthesis
using
HA
as
targeting
ligand.
Nanoparticles
loaded
H
O
can
enhance
chemodynamic
therapy
effects.
Simultaneously,
Cu
2+
generate
oxygen
in
TME
alleviate
hypoxia
tissue.
undergo
Fenton
reaction
produce
cytotoxic
hydroxyl
radicals
Ca
ions,
localization
clearance
cells.
Additionally,
sodium
alginate
(SA)
utilized
improve
biocompatibility
nanoparticles.
Fourier
transform
infrared,
x-ray
diffraction,
dynamic
light
scattering,
SEM,
transmission
electron
microscope,
other
analytical
methods
used
investigate
their
physical
chemical
properties.
results
indicate
that
CaO
NC
had
particle
size
220
nm,
narrow
distribution,
uniform
morphology.
hydrogen
peroxide
self-supplied
nanodrug
delivery
system
exhibited
excellent
pH-responsive
release
performance
glutathione-responsive
•OH
ability
while
also
reducing
level
reactive
oxide
species
quenching.
vitro
cell
experiments,
no
obvious
side
effects
on
normal
tissues
observed;
however,
inhibition
rate
malignant
tumors
HepG2
DU145
exceeded
50%.
preparation
nanoparticles,
achieve
both
chemokinetic
ion
interference
therapy,
has
demonstrated
significant
potential
clinical
applications
cancer
therapy.
Язык: Английский
Regulation of Oxygen in the Tumor Microenvironment Synergizes with Immunotherapy to Suppress Tumor Progression
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(12), С. 357 - 357
Опубликована: Ноя. 25, 2024
Hypoxia
represents
a
crucial
characteristic
of
the
tumor
microenvironment,
which
is
closely
related
to
cell
proliferation,
angiogenesis,
and
metabolic
responses.
These
factors
will
further
promote
progression,
increase
invasion,
enhance
metastasis
potential.
A
hypoxic
microenvironment
also
inhibit
activity
infiltrated
immune
cells
in
leading
failure
cancer
immunotherapy.
Additionally,
contributes
resistance
conventional
therapies
leads
unfavorable
prognoses.
This
review
discusses
advancements
strategies
aimed
at
ameliorating
hypoxia
within
modulating
responses
against
tumors.
Язык: Английский