Biomaterials Science,
Год журнала:
2023,
Номер
11(10), С. 3683 - 3694
Опубликована: Янв. 1, 2023
Development
of
polymeric
hydrogels
with
multiple
functions
(adhesiveness,
self-healability,
anti-oxidation
efficiency,
etc.)
through
one-step
green
polymerization
naturally
occurring
small
molecules
in
water
is
critical
for
various
biomedical
applications
and
clinical
transformation.
In
this
work,
benefiting
from
the
dynamic
disulfide
bond
α-lipoic
acid
(LA),
we
directly
obtain
an
advanced
hydrogel
(poly(lipoic
acid-co-sodium
lipoate)
(PLAS))
heat
concentration-induced
ring-opening
LA
addition
NaHCO3
aqueous
solution.
The
presence
COOH,
COO-
bonds
endows
resulting
comprehensive
mechanical
properties,
facile
injectability,
fast
self-healability
adequate
adhesiveness.
Moreover,
PLAS
show
promising
antioxidative
inherited
LA,
can
efficiently
eliminate
intracellular
reactive
oxygen
species
(ROS).
We
also
verify
advantage
a
rat
spinal
injury
model.
Through
regulation
ROS
situ
inflammation,
our
system
promote
recovery
cord
injury.
Owing
to
natural
origin
inherent
anti-oxidative
capability
preparation
method,
should
be
beneficial
transformation
may
good
candidate
applications.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Abstract
Direct
ink
writing
(DIW)
is
an
additive
manufacturing
technique
that
has
garnered
notable
interest
due
to
its
precise
and
consistent
printing
of
a
wide
range
materials,
such
as
viscoelastic
hydrogels,
pastes,
complex
composites,
by
adjusting
the
ink's
rheology.
This
material
flexibility
combined
with
ability
print
at
room
temperature
makes
DIW
ideal
for
diverse
applications
scalable
from
small
industrial
levels.
In
recent
years,
conductive
hydrogels
gained
significant
attention
across
various
fields,
ranging
biomedical
scaffolds
flexible
electronics.
Conductive
are
category
which
exhibit
conductivity
in
their
wet
and/or
dry
state.
Precursors
like
polymers,
metallic
nanoparticles,
carbon‐based
materials
can
be
used
induce
electronic
ionic
hydrogels.
review
presents
comprehensive
overview
demonstrating
printability
using
technique.
The
fundamentals
precursors
presented.
Following,
different
pathways
reaching
optimal
hydrogel
properties,
including
mechanical,
conductive,
rheological,
focus
on
synthesis
introduced.
Finally,
emerging
electronics
medicine
highlighted,
anticipated
challenges
advancement
printable
discussed.
Gels,
Год журнала:
2025,
Номер
11(4), С. 258 - 258
Опубликована: Апрель 1, 2025
Conductive
hydrogels,
integrating
high
conductivity,
mechanical
flexibility,
and
biocompatibility,
have
emerged
as
crucial
materials
driving
the
evolution
of
next-generation
wearable
sensors.
Their
unique
ability
to
establish
seamless
interfaces
with
biological
tissues
enables
real-time
acquisition
physiological
signals,
external
stimuli,
even
therapeutic
feedback,
paving
way
for
intelligent
health
monitoring
personalized
medical
interventions.
To
fully
harness
their
potential,
significant
efforts
been
dedicated
tailoring
conductive
networks,
properties,
environmental
stability
these
hydrogels
through
rational
design
systematic
optimization.
This
review
comprehensively
summarizes
strategies
categorized
into
metal-based,
carbon-based,
polymer-based,
ionic,
hybrid
systems.
For
each
type,
highlights
structural
principles,
conductivity
enhancement,
approaches
simultaneously
enhance
robustness
long-term
under
complex
environments.
Furthermore,
emerging
applications
in
sensing
systems
are
thoroughly
discussed,
covering
signal
monitoring,
mechano-responsive
platforms,
closed-loop
diagnostic–therapeutic
Finally,
this
identifies
key
challenges
offers
future
perspectives
guide
development
multifunctional,
intelligent,
scalable
hydrogel
sensors,
accelerating
translation
advanced
flexible
electronics
smart
healthcare
technologies.
Biomaterials Science,
Год журнала:
2023,
Номер
11(10), С. 3683 - 3694
Опубликована: Янв. 1, 2023
Development
of
polymeric
hydrogels
with
multiple
functions
(adhesiveness,
self-healability,
anti-oxidation
efficiency,
etc.)
through
one-step
green
polymerization
naturally
occurring
small
molecules
in
water
is
critical
for
various
biomedical
applications
and
clinical
transformation.
In
this
work,
benefiting
from
the
dynamic
disulfide
bond
α-lipoic
acid
(LA),
we
directly
obtain
an
advanced
hydrogel
(poly(lipoic
acid-co-sodium
lipoate)
(PLAS))
heat
concentration-induced
ring-opening
LA
addition
NaHCO3
aqueous
solution.
The
presence
COOH,
COO-
bonds
endows
resulting
comprehensive
mechanical
properties,
facile
injectability,
fast
self-healability
adequate
adhesiveness.
Moreover,
PLAS
show
promising
antioxidative
inherited
LA,
can
efficiently
eliminate
intracellular
reactive
oxygen
species
(ROS).
We
also
verify
advantage
a
rat
spinal
injury
model.
Through
regulation
ROS
situ
inflammation,
our
system
promote
recovery
cord
injury.
Owing
to
natural
origin
inherent
anti-oxidative
capability
preparation
method,
should
be
beneficial
transformation
may
good
candidate
applications.
