Visible-light-mediated synthesis of polysubstituted pyrroles via C_Ar–I reduction triggered 1,5-hydrogen atom transfer process

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(16), С. 4522 - 4528

Опубликована: Янв. 1, 2024

A novel strategy for the construction of polysubstituted pyrroles has been developed through visible-light-induced single-electron reduction C Ar –I bonds and following 1,5-hydrogen atom transfer (HAT) process.

Язык: Английский

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Metal-Free Nitrogen-Doped Mesoporous Carbons for the Mild and Selective Synthesis of Pyrroles from Nitroarenes via Cascade Reaction

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 16363 - 16372

Опубликована: Март 19, 2024

The cascade synthesis of pyrroles from nitroarenes is an attractive alternative strategy. However, metal catalysts and relatively high temperatures cover the existing reported catalytic systems for this development nonmetallic heterogeneous one-pot pyrrole under mild conditions both worthwhile challenging. Herein, we describe exceptionally efficient method N-substituted by reductive coupling diketones over metal-free conditions. Nonmetallic NC-X with activity were prepared pyrolysis well-defined ligands via simple sacrificing hard template methods. Hydrazine hydrate, formic acid, molecular hydrogen can all be used as reducing agents in hydrogenation/Paal–Knorr reaction sequence to efficiently synthesize various pyrroles, including drugs bioactive molecules. system was featured good tolerance sensitive functional groups no side reactions such dehalogenation aromatics hydrogenation. Hammett correlation studies have shown that electron-donating substituents are beneficial pyrroles. results established outstanding performance catalyst mainly attributed contribution graphitic N well promotion effect mesoporous structure on reaction.

Язык: Английский

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Multi-Aryl Pyrroles: Exploring Aggregation-Induced Emission for the Biological/Medical Applications

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112633 - 112633

Опубликована: Янв. 1, 2025

Язык: Английский

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Exploring the catalytic activity of –NHSO₃H functionalized natural asphalt: a sustainable and efficient catalyst for condensation reactions in water

RSC Advances, Год журнала: 2025, Номер 15(12), С. 9280 - 9294

Опубликована: Янв. 1, 2025

Natural asphalt sulfamic acid (NA-NHSO 3 H) was synthesized through the functionalization of natural (NA). The catalytic performance NA-NHSO H evaluated in Knoevenagel and Claisen–Schmidt condensation reactions under mild conditions.

Язык: Английский

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Metal- and oxidant-free skeletal reorganizing of oxazolidines to access N-Vinylpyrroles

Sustainable Chemistry and Pharmacy, Год журнала: 2024, Номер 42, С. 101768 - 101768

Опубликована: Сен. 17, 2024

Язык: Английский

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Molybdenum‐Catalyzed Direct Synthesis of Pyrroles from Nitroarenes with Glycols as Reductants

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Abstract A molybdenum‐catalyzed synthesis of N ‐(hetero)aryl pyrroles directly from inexpensive and commonly available (hetero)nitroarenes via reduction with pinacol annulation 1,4‐dicarbonyls or cyclobutane‐1,2‐diols has been described. The process does not require an inert atmosphere tolerates the presence air water. This non‐noble catalytic system shows high chemoselectivity, allowing a diverse range potentially reducible functional groups such as alkynes, alkenes, halogens, cyano, carbonyls. Moreover, this strategy enables reuse waste byproduct reactant, facilitating formation challenging accessible used reducing agents.

Язык: Английский

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Recent Advances in Nonprecious Metal Catalysis

Organic Process Research & Development, Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

As the field of nonprecious metal catalysis continues to expand, we pursue a review series covering selected transformations in this area over short time interval highlight practical advancements. We seek raise awareness both current art and need continue development toward broader applications earth-abundant metals chemical pharmaceutical industries.

Язык: Английский

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Design of natural asphalt sulfamic acid (NA-NHSO3H) as a scalable natural asphalt-derived heterogeneous Brønsted acid to catalyze multicomponent reactions meeting green chemistry goals

Heliyon, Год журнала: 2024, Номер 11(1), С. e41492 - e41492

Опубликована: Дек. 25, 2024

Язык: Английский

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Five-membered ring systems: Pyrroles and benzo analogs

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173

Опубликована: Янв. 1, 2024

Язык: Английский

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The Dual Role of Formic Acid in the Synthesis of N-Arylated Pyrroles from Nitroarenes

Synfacts, Год журнала: 2023, Номер 20(01), С. 0017 - 0017

Опубликована: Дек. 8, 2023

Язык: Английский

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