Scalable Flow Electrosynthesis of Iminophosphoranes
Organic Process Research & Development,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
A
scalable
electrochemical
process
to
synthesize
iminophosphorane
ligands
is
reported.
The
application
of
these
iminophosphoranes
was
recently
reported
in
Ni-catalyzed
cross-electrophile
and
C–N
cross-couplings.
use
parallel
plate
flow
reactors
enables
the
synthesis
on
a
multigram
scale,
with
selected
examples
up
0.6
kg
scale.
Direct
crystallization
from
end
reaction
mixture
for
provides
facile
isolation
processes.
This
article
also
details
improvements
our
capabilities
across
scales,
including
addressing
material
compatibility
issues,
increasing
accessible
range
rates,
integration
analytical
technology
tools.
Язык: Английский
Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey
Organic Process Research & Development,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Synthesis, Characterization, and Catalytic Activity of Ni(0) (DQ)dtbbpy, an Air-Stable, Bifunctional Red-Light-Sensitive Precatalyst
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Despite
a
well-established
and
growing
body
of
work
on
nickel(0)
precatalysts,
the
potential
complexes
as
bifunctional
precatalysts
remains
underexplored.
In
this
study,
we
synthesized,
characterized,
evaluated
catalytic
activity
(Ni(0)(DQ)dtbbpy),
bifunctional,
red-light-sensitive,
air-stable
complex.
Owing
to
its
unique
photophysical
properties,
it
effectively
catalyzed
etherification
amination
aryl
bromides
under
620–630
nm
light
irradiation,
functioning
both
photocatalyst
an
active
metal
catalyst.
Mechanistic
studies
density
functional
theory
(DFT)
calculations
further
confirmed
exceptional
absorption
properties
Ni(0)(DQ)dtbbpy
in
red-light
region,
well
electron
transfer
process
triggered
by
irradiation.
Язык: Английский
A Scalable Flow Electrolysis of Heterogeneous Mixtures Using a Rotating Cylinder Electrode Reactor: Access to a Chiral Iminophosphorane
Organic Process Research & Development,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
We
report
the
application
of
rotating
cylinder
electrode
(RCE)
reactors
for
electrolysis
heterogeneous
reactions
in
batch
and
recirculating
flow.
A
scalable
method
synthesis
an
N-cyano
iminophosphorane
ligand
RCE
reactor
is
also
reported.
In
development
this
process,
a
graphite
felt
attached
to
inner
impervious
was
used
as
anode,
outer
stainless
steel
wall
cathode.
The
reaction
first
evaluated
using
small
optimize
spinning
rate,
supporting
electrolyte,
current
density.
optimal
condition
then
scaled
up
medium-sized
with
modifications
adapt
it
flow
process.
electrosynthesis
demonstrated
100
g
scale,
impact
temperature
investigated.
Finally,
operationally
simple
direct
crystallization
water
antisolvent
provided
chiral
74%
isolated
yield
on
scale
from
commercially
available
(S)-BINAP
bis(trimethylsilyl)carbodiimide.
Язык: Английский
Trendbericht: Organische Chemie 2025
Nachrichten aus der Chemie,
Год журнала:
2025,
Номер
73(3), С. 40 - 70
Опубликована: Фев. 28, 2025
Abstract
Highlights
von
November
2023
bis
2024:
die
erste
Einelektron‐C–C‐σ‐Bindung
und
Anti‐Bredt‐Verbindung;
gesättigte
Heterocyclen
elektrochemisch
funktionalisieren;
Ausrichten
diskotischer
Flüssigkristalle;
enantioselektive
Wagner‐Meerwein‐Umlagerung
reiner
Aliphaten;
photokatalytisch
Furanen
zu
Pyrrolen;
mit
Ammoniak
primären
Arylaminen;
Metallschrott
recyceln
ionischen
Flüssigkeiten;
terminale
Alkene
Ni‐Katalysatoren
zum
(Z)‐
oder
(E)‐Alken
isomerisieren;neue
Fungizide,
Medikamente
Alkaloide.
Recent advances in the electrochemical synthesis of organophosphorus compounds
Beilstein Journal of Organic Chemistry,
Год журнала:
2025,
Номер
21, С. 770 - 797
Опубликована: Апрель 16, 2025
In
this
review,
we
describe
recent
advances
in
electrochemical
green
methods
for
the
synthesis
of
various
organophosphorus
compounds
through
formation
phosphorus–carbon,
phosphorus–nitrogen,
phosphorus–oxygen,
phosphorus–sulfur,
and
phosphorus–selenium
bonds.
The
impact
different
electrodes
is
also
discussed
matter.
Graphite,
platinum,
RVC,
nickel
have
been
used
extensively
compounds.
made
method
a
promising
preparing
structures.
This
review
an
introduction
to
encourage
scientists
use
electrosynthesis
as
green,
precise,
low-cost
prepare
phosphorous
Язык: Английский
Efficient and Sustainable Electrosynthesis of N-Sulfonyl Iminophosphoranes by the Dehydrogenative P–N Coupling Reaction
JACS Au,
Год журнала:
2024,
Номер
4(6), С. 2188 - 2196
Опубликована: Апрель 18, 2024
Iminophosphoranes
are
commonly
used
reagents
in
organic
synthesis
and
are,
therefore,
of
great
interest.
An
efficient
sustainable
iodide-mediated
electrochemical
N-sulfonyl
iminophosphoranes
from
readily
available
phosphines
sulfonamides
is
reported.
This
method
features
low
amounts
supporting
electrolytes,
inexpensive
electrode
materials,
a
simple
galvanostatic
setup,
high
conversion
rates.
The
broad
applicability
could
be
demonstrated
by
synthesizing
20
examples
yields
up
to
90%,
having
diverse
functional
groups
including
chiral
moieties
biologically
relevant
species.
Furthermore,
electrolysis
was
performed
on
g
scale
run
repetitive
mode
recycling
the
electrolyte,
which
illustrates
suitability
for
large-scale
production.
A
reaction
mechanism
involving
mediation
iodide-based
electrolyte
proposed,
completely
agreeing
with
all
results.
Язык: Английский