Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110799 - 110799
Опубликована: Дек. 1, 2024
Язык: Английский
Receptors, Год журнала: 2024, Номер 3(3), С. 323 - 361
Опубликована: Июль 3, 2024
Receptor-targeted drug delivery has been extensively explored for active targeting of therapeutic moiety in cancer treatment. In this review, we discuss the receptors that are overexpressed on tumor cells and have potential to be targeted by nanocarrier systems We also highlight different types ligands researchers explored. Our discussion covers various modalities, including small molecules, aptamers, peptides, antibodies, cell-based strategies, focuses clinical developments. Additionally, article highlights challenges arise during translation nanocarrier-based strategies. It provides future directions improving research area clinically translatable cancer-targeted therapy improve treatment efficacy while minimizing toxicity.
Язык: Английский
Процитировано
12
Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 3, 2025
Язык: Английский
Процитировано
1
Nanoscale, Год журнала: 2025, Номер 17(9), С. 5033 - 5055
Опубликована: Янв. 1, 2025
Core-shell PDMS-HA nanoparticles for targeted tumor therapy, delivering doxorubicin and quercetin sequentially effectively bypasses P-glycoprotein efflux, improving drug retention efficacy. Created in BioRender. Verma, M. (2025) https://BioRender.com/y29e681
Язык: Английский
Процитировано
1
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(3), С. 74 - 74
Опубликована: Март 20, 2024
Background: Gynecological cancers are a significant public health concern, accounting for 40% of all cancer incidence and 30% deaths in women. 5-Fluorouracil (5-FU) can be used with chemotherapy to improve treatment advanced-stage gynecological cancer. Mesoporous silica nanoparticles (MSNs) drug effectiveness reduce toxicity. Folic acid target folate receptors epithelial malignancies like ovarian cervical Methods: The mixture MSN-NH2 was synthesized by dissolving N-lauroylsarcosine sodium water–ethanol mixture, adding APTES TEOS, heating at 80 °C 18 h, before being fully characterized. is loaded into 5-FU solution functionalized folate. release mechanism, as well ex vivo intestinal permeation from formulations, tested. cell viability study the evaluated various lines, cellular uptake measured indirectly using HPLC. Results: analyzed amine content, propylamine loading, loading capacity nanoparticles. It found that around 0.733 mmol/g, surface density 0.81 molecules/nm. also showed decoration folic successfully achieved. rate slow controlled, slower pH 5.5. amin functionalization potential toxicity cells. Conclusions: Based on results, encapsulation serve carriers treating
Язык: Английский
Процитировано
6
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117118 - 117118
Опубликована: Июль 14, 2024
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125262 - 125262
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Although numerous technical advances have been made in cancer treatment, chemotherapy is still a viable treatment option. However, it more effective when used combination with photothermal therapy for resistant breast cells. This study introduces smart drug delivery system, (DOX-OA+VERA+AuNRs)@NLC, which designed dual chemo/photothermal of multiple-drug-resistant cancer. Type-III nanostructured lipid carriers (NLCs) were as systems, where nano-in-nano structures offer several advantages. Doxorubicin (DOX) was the antitumor agent by ion-pairing oleic acid (OA) to increase DOX loading capacity, well reduce burst release drug. Verapamil (VERA), chemosensitizer overcome multiple-drug resistance, co-loaded DOX-OA. Gold nanorods (AuNRs) exploited (PTT) application, would synergistic relation chemotherapy. The DOX-OA and VERA from NLCs studied vitro triggering NIR laser irradiation. Thus, an all-in-one system active pharmaceutical ingredients (APIs) at higher concentrations desired region provide both chemo/PTT. Besides, application folic acid-chitosan (FA-CS) coating has facilitated development systems capable targeting specifically releasing their cargo within cancerous tissues while preserving surrounding environment.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 1 - 16
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Starch - Stärke, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
ABSTRACT The biocompatible and biodegradable polysaccharide starch is a great platform for the development of nanoparticles (NPs). Due to its special qualities, which include high stability, low toxicity, ease modification, it desirable option administration anticancer drugs. Targeted cancer therapy has found potential carrier in starch‐based (SNPs). SNPs can be functionalized with ligands target cells particular. These allow targeted medication delivery by identifying overexpressed receptors on tumor surfaces. have been studied relation chemotherapeutics, siRNAs, photothermal treatments, among other agents. They are also used combination therapy, where their combined targeting improves treatment outcomes. being evaluated number clinical trials. trials evaluate patient outcomes, safety, efficacy offer important information future uses. Regulatory bodies closely monitor various treatments based NPs. Clinical translation requires an understanding safety profiles, biodistribution, clearance mechanisms. In this review, we examine enhance through drug targeting.
Язык: Английский
Процитировано
0
Exploration of Targeted Anti-tumor Therapy, Год журнала: 2025, Номер 6
Опубликована: Март 18, 2025
Pancreatic cancer is a challenging disease with limited treatment options and high mortality rate. Just few therapy advances have been made in recent years. Tumor microenvironment, immunosuppressive features mutational status represent important obstacles the improvement of survival outcomes. Up to now, first-line did achieve median overall less than 12 months this discouraging data lead clinicians all over world focus their efforts on various fields investigation: 1) sequential cycling different systemic order overcome mechanisms resistance; 2) discovery new predictive bio-markers, target specific patient population; 3) combination treatment, modulate tumor microenvironment pancreatic cancer; 4) modalities delivery drugs pass physical barrier desmoplasia stroma. This review shows future directions strategies advanced through deep analysis these macro areas research.
Язык: Английский
Процитировано
0