Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 11, 2024
An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C-N bonds by making use of a simple nitrogen source, such as NH
Язык: Английский
Chemistry - A European Journal, Год журнала: 2024, Номер 30(62)
Опубликована: Авг. 10, 2024
The difunctionalization of alkenes represents a powerful tool to incorporate two functional groups into the alkene bones for increasing molecular complexity and has been widely utilizations in chemical synthesis. Upon catalysis green, sustainable, mild photo-/electrochemistry technologies, much attentions have attracted development new tactics transformations important alkane feedstocks driven by C-H radical functionalization. Herein, we summarize recent advances photo-/electrocatalytic enabled We detailedly discuss substrate scope mechanisms reactions selecting impressive synthetic examples, which are divided four sections based on final terminated step, including oxidative radical-polar crossover coupling, reductive radical-radical transition-metal-catalyzed coupling.
Язык: Английский
Процитировано
8
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Abstract Owing to their wide utilizations in synthesis and products prevalence numerous natural products, pharmaceuticals functional materials, the alkene difunctionalization methods for selective transformations of olefins are important have attracted much attention form synthetic chemists. Among them, electrochemical reaction is particularly promising has becoming a potent sustainable tool alkenes into vicinal difunctionalized structures organic through simultaneous incorporation two groups. Herein, we summarize recent progress reactions according types as well category radicals over past five years. By selecting remarkable examples, elaborately discussed substrate scope mechanisms olefin reaction.
Язык: Английский
Процитировано
1
Organic & Biomolecular Chemistry, Год журнала: 2025, Номер 23(10), С. 2323 - 2357
Опубликована: Янв. 1, 2025
In recent years, significant achievements have been made in the field of electroorganic chemistry regarding difunctionalization alkenes. Researchers developed innovative strategies utilizing unique reactivity electrochemical processes to synthesize complex molecules with high regioselectivity and stereoselectivity. This technology is widely applied total synthesis natural products pharmaceutical industry. article reviews research progress alkenes through three different radical-mediated pathways over past five years. It includes discussions on 1,2-stereoselective non-diastereoselective reactions, rearrangements, intramolecular migrations, cyclization processes. The summary emphasizes electrode designs, reaction mechanisms, integration other emerging technologies, highlighting potential this method modern organic chemistry. Additionally, it aims address current challenges propose possible solutions, providing a promising direction for electrochemically mediated reactions
Язык: Английский
Процитировано
0
RSC Advances, Год журнала: 2025, Номер 15(7), С. 5167 - 5189
Опубликована: Янв. 1, 2025
The Mitsunobu reaction is a key bimolecular nucleophilic substitution for synthesizing chiral products. This paper highlights its importance in biologically active compounds, focusing on forming C–N single bonds.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2025, Номер unknown, С. e42938 - e42938
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110425 - 110425
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
3
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(17), С. 12378 - 12386
Опубликована: Авг. 22, 2024
Photocatalyst-free visible light-enabled direct oxygenation of furan-tethered α-azidoketones was studied. The reaction yielded various products depending on the substituents, with isoxazoles forming as major products. findings suggest that singlet oxygen generated during and reacted in a [4 + 2] fashion to yield endoperoxides, which rearranged multiple ways generate isoxazoles. Some synthesized were evaluated α-glucosidase inhibitors, three them 5bi, 5bj, 5bl exhibited good activity IC50 values 454.57 ± 29.34, 147.84 2.28, 272.58 42.06 μM, respectively, when compared standard drug acarbose (IC50 = 1224.33 126.72 μM).
Язык: Английский
Процитировано
1
Green Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
A metal- and oxidizing reagent-free electrochemical dehydrogenative annulation of enamides with O -nucleophiles has been developed, leading to a series 4-oxo-oxazolines under environmentally friendly conditions.
Язык: Английский
Процитировано
1
Reaction Chemistry & Engineering, Год журнала: 2024, Номер 10(3), С. 500 - 510
Опубликована: Дек. 20, 2024
Multicomponent reactions (MCRs) have become excellent tools for synthesizing complex and high-value molecules. This minireview highlights recent progresses in MCRs classified by the type of catalysts to offer a better deeper understanding.
Язык: Английский
Процитировано
1
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(19), С. 4122 - 4131
Опубликована: Июль 12, 2024
Abstract Here we report a transition metal– and oxidant–free annulation cascade method for the synthesis of chromeno–isoxazoles. The reaction involves easily accessible starting materials, 3‐nitro‐2 H ‐chromene α ‐chloro aldehyde, yielding structurally intriguing framework, chromeno[3,4‐ c ]isoxazoles employed by tripotassium phosphate as base. isoxazole ring construction over 2 –chromene unit is believed to occur via series multiple sequences. Here, enolate generation/Michael addition/C−Cl bond cleavage/oxy–anionic addition reactive tethered‐aldehyde/deformylation retro–C−C N−O cleavages are most possible sequences which furnish desired end–product in good chemical yields. one‐pot at mild conditions, supported experimental results few control experiments including DFT studies. This process exhibits broad substrates scope illustrating functional group compatibility towards both nitrochromenes aldehydes, thus prove be general efficient protocol chromeno[3,4– ]isoxazoles. Overall, use nitrochromene limiting reagent, noteworthy tolerance, scalability great applications like chiral pool strategy enantioenriched chromeno‐isoxazole additional features.
Язык: Английский
Процитировано
0