Synthesis of Coumarin-Based Photosensitizers for Enhanced Antibacterial Type I/II Photodynamic Therapy

Molecules, Год журнала: 2024, Номер 29(16), С. 3793 - 3793

Опубликована: Авг. 10, 2024

Photodynamic therapy (PDT) is an effective method for treating microbial infections by leveraging the unique photophysical properties of photosensitizing agents, but issues such as fluorescence quenching and restricted generation reactive oxygen species (ROS) under hypoxic conditions still remain. In this study, we successfully synthesized designed a coumarin-based aggregation-induced emission luminogen (AIEgen), called ICM, that shows remarkable capacity type I ROS II generation. The 1O2 yield ICM 0.839. it produces include hydroxyl radicals (HO•) superoxide anions (O2•−), with highly antibacterial specifically targeting Staphylococcus aureus (a Gram-positive bacterium). Furthermore, enables broad-spectrum imaging exhibits excellent biocompatibility. Consequently, potent photosensitizer eliminating pathogenic microorganisms, represents promising tool in addressing threat posed these pathogens.

Язык: Английский

NIR-induced antimicrobial efficacy of TPA-BOIMPY conjugate through photothermal and photodynamic synergy

Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2024, Номер 460, С. 116136 - 116136

Опубликована: Ноя. 12, 2024

Язык: Английский

Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 261, С. 113052 - 113052

Опубликована: Ноя. 5, 2024

Язык: Английский