Graphitic carbon nitride nanosheet and ferroelectric PbTiO3 nanoplates S-scheme heterostructure for enhancing hydrogen production and textile dye degradation

Chemical Engineering Science, Год журнала: 2024, Номер 295, С. 120133 - 120133

Опубликована: Апрель 16, 2024

Язык: Английский

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Near-Infrared-Responsive Photoelectrochemical Biosensors

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 179, С. 117890 - 117890

Опубликована: Июль 30, 2024

Язык: Английский

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Facile synthesis of yellow emissive heteroatom doped carbon quantum dots fluorescent probe with superior quantum yield for fast-track ionic detection in aqueous media

Materials Research Bulletin, Год журнала: 2024, Номер 180, С. 113040 - 113040

Опубликована: Авг. 8, 2024

Язык: Английский

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Enhanced domestic 12 W LED light-driven Rhodamine B degradation by Z-scheme CoFe2O4/PDA/g-C3N4 ternary heterojunction

Ceramics International, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Multifaceted Sulfonamide-Derived Thiosemicarbazones: Combining Metal Chelation and Carbonic Anhydrases Inhibition in Anticancer Therapy

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1225 - 1225

Опубликована: Янв. 30, 2025

The selective inhibition of key enzymes, such as carbonic anhydrases (CAs IX and XII), which are overexpressed in cancer tissues, has emerged a promising strategy research. However, multitarget approach is often preferred to achieve enhanced therapeutic outcomes. In this study, aryl sulfonamides were conjugated with thiosemicarbazone moiety enable dual functionality: the CAs chelation metal cations. Several structural factors systematically modified, including position sulfonamido group, length linker, nature aromatic residue, type substituents. Tumor-associated XII was evaluated using stopped-flow CO2 hydrase assay, constants (Ki) determined. most compounds further analyzed through molecular docking simulations. Metal capabilities UV–Vis spectroscopy, while antiproliferative activities measured sulforhodamine B (SBR) assay. Additionally, holotomographic 3D microscopy employed investigate mechanisms cell death. Sulfonamido-derived Schiff bases synthesized three-step procedure that did not require column chromatography purification: (1) isothiocyanation amino-sulfonamides, (2) nucleophilic addition hydrazine, (3) acid-promoted condensation different aldehydes (benzaldehydes or pyridine-2-carboxaldehyde). exhibited low nanomolar submicromolar range, selectivity largely influenced by features. Notably, m-sulfonamide derivative 5b, bearing pyridin-2-yl demonstrated potent CA (Ki = 4.9 nM) 5.6 nM). it efficiently chelated Fe2+, Fe3+, Cu2+ showed activity (GI50 4.5–10 µM). Mechanistic studies revealed apoptosis involved its mode action. Therefore, synergistic integration thiosemicarbazones represents an effective for development multimodal anticancer agents.

Язык: Английский

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Research status of biomaterials based on physical signals for bone injury repair

Regenerative Therapy, Год журнала: 2025, Номер 28, С. 544 - 557

Опубликована: Фев. 13, 2025

Язык: Английский

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Rational Fabrication of Copper Nanoclusters and In Vitro Study of Antioxidant Property

Nanomaterials, Год журнала: 2025, Номер 15(5), С. 360 - 360

Опубликована: Фев. 26, 2025

Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, is a critical factor in the pathogenesis of wide range diseases. The excessive accumulation ROS can cause severe cellular damage, leading to tissue dysfunction disease progression. development nanomaterials with antioxidant properties presents promising strategy for addressing this challenge. Herein, we report fabrication albumin-biomineralized copper nanoclusters (BCNCs) as novel platform evaluate their effectiveness combating oxidative stress. Our results show that BCNCs exhibit potent scavenging abilities protect cells stress-induced highlighting potential effective therapeutic stress-related

Язык: Английский

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Synergistic Therapeutic Effects of Prussian Blue Erbium-Doped Hydroxyapatite Nanoparticles in Photothermal Photodynamic Cancer Therapy

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

This study explores the synergistic therapeutic potential of Prussian Blue Erbium-Doped Hydroxyapatite (PB-Er-HAp) bioceramics in context photothermal therapy (PTT) and photodynamic (PDT) for cancer treatment, highlighting their role multimodal approaches imaging. PB-Er-HAp nanoparticles (NPs) were synthesized using a facile coprecipitation method to incorporate erbium (Er) into nanostructured hydroxyapatite (HAp) at various concentrations. (PB) was functionalized onto surfaces these NPs, resulting final particle size less than 50 nm. The efficacy 1.0 mol % NPs evaluated vitro, MDA-MB-231 breast cells. In vitro studies demonstrated that exhibited significant PTT PDT effects under 808 nm laser irradiation, effectively inducing cell death through heat generation reactive oxygen species production, respectively. experiments validated ability inhibit tumor growth line. emphasizes as versatile platform therapy, combining effects, while offering capabilities biomedical Future research aims further optimize explore clinical application, aiming toward enhanced outcomes treatment.

Язык: Английский

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Development of iron oxide based-upconversion nanocomposites for cancer therapeutics treatment

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125545 - 125545

Опубликована: Март 1, 2025

Язык: Английский

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Heterostructured Sn/Co oxides for electrocatalytic reduction of nitrate to ammonia

Journal of Alloys and Compounds, Год журнала: 2025, Номер unknown, С. 180522 - 180522

Опубликована: Апрель 1, 2025

Язык: Английский

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