A systematic review of cardiovascular toxicities induced by cancer immune therapies: underlying mechanisms, clinical manifestations and therapeutic approaches DOI
Li Liu, Wentao Yao,

Mi Wang

и другие.

Seminars in Cancer Biology, Год журнала: 2024, Номер 106-107, С. 179 - 191

Опубликована: Окт. 22, 2024

Язык: Английский

Engineered algae microrobots as photosynthetic living materials promote T cells’ anti-tumor immunity DOI Creative Commons

Fanqiang Meng,

Lin Zhong-da,

Yumeng Ma

и другие.

Cell Reports Physical Science, Год журнала: 2024, Номер 5(6), С. 102023 - 102023

Опубликована: Июнь 1, 2024

Dendritic cells (DCs) can form a T cell niche in tumor microenvironment and drive proliferation through immunostimulatory ligands. However, hypoxia severely hinders the infiltration of immune cells, thus restricting cells' anti-tumor response. Microalgae have evolved an efficient photosynthesis system that might be promising oxygen source to mitigate hypoxia. Here, we combine Chlorella vulgaris genetically engineered DC membrane, overexpressing necrosis factor (TNF) ligand proteins OX40L, 4-1BBL, CD70, assemble "photosynthetic micron robot," which generates situ alleviate state microenvironment, thereby improving efficiency immunotherapy. TNF displayed on membrane nanovesicles photosynthetic robot bind their cognate receptors enhance activity effector memory cells. Combined with programmed death-1 antibody, prevents relapse metastasis mouse model.

Язык: Английский

Процитировано

15

Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development DOI Creative Commons
Meiyan Wu, Yuan Liao,

Di Guo

и другие.

RSC Advances, Год журнала: 2024, Номер 14(21), С. 14722 - 14741

Опубликована: Янв. 1, 2024

Manganese-based nanomaterials have seen rapid development in chemodynamic therapy and T 1 -enhanced MRI over the past five years, holding promising prospects various combined applications.

Язык: Английский

Процитировано

10

Lung-Targeted Delivery of PTEN mRNA Combined with anti-PD-1-mediated Immunotherapy for In Situ Lung Cancer Treatment DOI

Yue Hu,

Xi He, Ping Chen

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Recent Developments in Combination Immunotherapy with Other Therapies and Nanoparticle-Based Therapy for Triple-Negative Breast Cancer (TNBC) DOI Open Access
Gantumur Battogtokh, Onyinyechi Obidiro, Emmanuel O. Akala

и другие.

Cancers, Год журнала: 2024, Номер 16(11), С. 2012 - 2012

Опубликована: Май 25, 2024

Triple-negative breast cancer (TNBC), lacking specific receptors found in other subtypes, poses significant treatment challenges due to limited therapeutic options. Therefore, it is necessary develop novel approaches for TNBC. In the last few decades, many attempts have been reported alternative tools TNBC treatment: immunotherapy, radiotherapy, targeted therapy, combination and nanotechnology-based therapy. Among them, therapy show most promise treatment. This review outlines recent advancements these areas, highlighting efficacy of (immunotherapy paired with chemotherapy, or radiotherapy) both preclinical clinical stages therapies utilizing various nanoparticles loaded anticancer agents, nucleic acids, immunotherapeutics, CRISPRs

Язык: Английский

Процитировано

7

Melanin/melanin-like nanoparticles in tumor photothermal and targeted therapies DOI Creative Commons
Jing Wu,

Yilin Xu,

Donghai Wu

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125354 - 125354

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Leading prodrug strategies for targeted and specific release DOI Creative Commons
Rupa Bargakshatriya, Sumit Kumar Pramanik

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 4

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

1

A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances DOI

Shuteng Wang,

Yifan Liu,

Chunhua Quan

и другие.

Biomaterials Science, Год журнала: 2024, Номер 12(4), С. 896 - 906

Опубликована: Янв. 1, 2024

With the growing need for more effective tumour treatment, piezocatalytic therapy has emerged as a promising approach due to its distinctive capacities generate ROS through stress induction and regulate hypoxic state of TME. MOF-based piezocatalysts not only possess benefits piezocatalysis but also exhibit several advantages associated with MOFs, such tunable pore size, large specific surface area, good biocompatibility. Therefore, they are expected become powerful promoter therapy. This review elaborates on fundamental principles summarises recent advances in combination therapies tumours, generalising strategies constructing systems based MOFs. Finally, challenges confronted future opportunities design application MOF anticancer have been discussed.

Язык: Английский

Процитировано

6

Clinical characteristics and novel strategies of immune checkpoint inhibitor rechallenge therapy for non-small cell lung cancer: a comprehensive review DOI Creative Commons
Hao Zhang,

Yujun Hu,

Tingting Wu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 12, 2024

Treatment of non-small-cell lung cancer (NSCLC) has entered the immunotherapy era, marked by significant survival improvements due to use immune checkpoint inhibitors (ICIs). However, owing factors, such as disease progression, long-term use, and side effects, some patients discontinue immunotherapy, resulting in limited subsequent treatment option a negative impact on their quality life. We have collected relevant data which reveal that ICI rechallenge may be an effective clinical strategy. many factors affect efficacy rechallenge, including patient characteristics, initial drugs, duration, efficacy, toxicity, effects. Additionally, effects mechanisms reversing drug resistance play crucial roles. Identifying suitable candidates, optimizing plans enhancing minimizing toxicity adverse rechallenges are pressing needs. Addressing these issues can provide guidance for better serve patients. This review focuses considerations strategies therapy NSCLC.

Язык: Английский

Процитировано

4

Sustainable nanomaterials for precision medicine in cancer therapy DOI
Ashkan Bigham, Atefeh Zarepour, Arezoo Khosravi

и другие.

Materials Today Sustainability, Год журнала: 2024, Номер 27, С. 100865 - 100865

Опубликована: Май 27, 2024

Язык: Английский

Процитировано

4

A Virus-Inspired RNA Mimicry Approach for Effective Cancer Immunotherapy DOI

In-Suk Jang,

Kyuha Yum,

Sang Woo Han

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Current cancer treatments, including chemotherapy, surgery, and radiation, often present significant challenges such as severe side effects, drug resistance, damage to healthy tissues. To address these issues, we introduce a virus-inspired RNA mimicry approach, specifically through the development of uridine-rich nanoparticles (UNPs) synthesized using rolling circle transcription (RCT) technique. These UNPs are designed mimic poly-U tail sequences viral RNA, effectively engaging RIG-I-like receptors (RLRs) MDA5 LGP2 in cells. Activation leads upregulation pro-inflammatory cytokines initiation apoptosis, resulting targeted cell death. Importantly, this strategy overcomes limitations traditional therapies enhances effectiveness existing RIG-I stimulators, poly(I:C), which has exhibited toxicity clinical settings due delivery methods. Our vivo studies further demonstrate ability significantly reduce tumor growth without adverse highlighting their potential novel effective approach immunotherapy. This offers new therapeutic strategies that leverage body's innate antiviral mechanisms for treatment.

Язык: Английский

Процитировано

0