Engineered algae microrobots as photosynthetic living materials promote T cells’ anti-tumor immunity

Cell Reports Physical Science, Год журнала: 2024, Номер 5(6), С. 102023 - 102023

Опубликована: Июнь 1, 2024

Dendritic cells (DCs) can form a T cell niche in tumor microenvironment and drive proliferation through immunostimulatory ligands. However, hypoxia severely hinders the infiltration of immune cells, thus restricting cells' anti-tumor response. Microalgae have evolved an efficient photosynthesis system that might be promising oxygen source to mitigate hypoxia. Here, we combine Chlorella vulgaris genetically engineered DC membrane, overexpressing necrosis factor (TNF) ligand proteins OX40L, 4-1BBL, CD70, assemble "photosynthetic micron robot," which generates situ alleviate state microenvironment, thereby improving efficiency immunotherapy. TNF displayed on membrane nanovesicles photosynthetic robot bind their cognate receptors enhance activity effector memory cells. Combined with programmed death-1 antibody, prevents relapse metastasis mouse model.

Язык: Английский

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Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development

RSC Advances, Год журнала: 2024, Номер 14(21), С. 14722 - 14741

Опубликована: Янв. 1, 2024

Manganese-based nanomaterials have seen rapid development in chemodynamic therapy and T 1 -enhanced MRI over the past five years, holding promising prospects various combined applications.

Язык: Английский

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Recent Developments in Combination Immunotherapy with Other Therapies and Nanoparticle-Based Therapy for Triple-Negative Breast Cancer (TNBC)

Cancers, Год журнала: 2024, Номер 16(11), С. 2012 - 2012

Опубликована: Май 25, 2024

Triple-negative breast cancer (TNBC), lacking specific receptors found in other subtypes, poses significant treatment challenges due to limited therapeutic options. Therefore, it is necessary develop novel approaches for TNBC. In the last few decades, many attempts have been reported alternative tools TNBC treatment: immunotherapy, radiotherapy, targeted therapy, combination and nanotechnology-based therapy. Among them, therapy show most promise treatment. This review outlines recent advancements these areas, highlighting efficacy of (immunotherapy paired with chemotherapy, or radiotherapy) both preclinical clinical stages therapies utilizing various nanoparticles loaded anticancer agents, nucleic acids, immunotherapeutics, CRISPRs

Язык: Английский

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Lung-Targeted Delivery of PTEN mRNA Combined with anti-PD-1-mediated Immunotherapy for In Situ Lung Cancer Treatment

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Melanin/melanin-like nanoparticles in tumor photothermal and targeted therapies

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125354 - 125354

Опубликована: Фев. 1, 2025

Язык: Английский

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Leading prodrug strategies for targeted and specific release

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 4

Опубликована: Март 14, 2025

Язык: Английский

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A peptide-nanoparticle conjugate to steer elimination of drug-resistance bacteria and LPS

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161993 - 161993

Опубликована: Март 1, 2025

Язык: Английский

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A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Biomaterials Science, Год журнала: 2024, Номер 12(4), С. 896 - 906

Опубликована: Янв. 1, 2024

With the growing need for more effective tumour treatment, piezocatalytic therapy has emerged as a promising approach due to its distinctive capacities generate ROS through stress induction and regulate hypoxic state of TME. MOF-based piezocatalysts not only possess benefits piezocatalysis but also exhibit several advantages associated with MOFs, such tunable pore size, large specific surface area, good biocompatibility. Therefore, they are expected become powerful promoter therapy. This review elaborates on fundamental principles summarises recent advances in combination therapies tumours, generalising strategies constructing systems based MOFs. Finally, challenges confronted future opportunities design application MOF anticancer have been discussed.

Язык: Английский

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Clinical characteristics and novel strategies of immune checkpoint inhibitor rechallenge therapy for non-small cell lung cancer: a comprehensive review

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 12, 2024

Treatment of non-small-cell lung cancer (NSCLC) has entered the immunotherapy era, marked by significant survival improvements due to use immune checkpoint inhibitors (ICIs). However, owing factors, such as disease progression, long-term use, and side effects, some patients discontinue immunotherapy, resulting in limited subsequent treatment option a negative impact on their quality life. We have collected relevant data which reveal that ICI rechallenge may be an effective clinical strategy. many factors affect efficacy rechallenge, including patient characteristics, initial drugs, duration, efficacy, toxicity, effects. Additionally, effects mechanisms reversing drug resistance play crucial roles. Identifying suitable candidates, optimizing plans enhancing minimizing toxicity adverse rechallenges are pressing needs. Addressing these issues can provide guidance for better serve patients. This review focuses considerations strategies therapy NSCLC.

Язык: Английский

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Sustainable nanomaterials for precision medicine in cancer therapy

Materials Today Sustainability, Год журнала: 2024, Номер 27, С. 100865 - 100865

Опубликована: Май 27, 2024

Язык: Английский

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