Abstract
In
this
study,
we
aim
to
investigate
the
family
of
porphyrins
from
a
novel
perspective.
particular,
focus
on
their
role
in
controlling
assembly
gold
nanorods
(AuNRs)
through
synthetic
approach.
Using
seed‐mediated
growth
method,
AuNRs
were
first
synthesized.
Then,
surfaces
functionalized
with
four
different
types
explore
unique
influence
process.
Two
pairs
synthesized:
metal‐free
1
and
2
two
corresponding
zinc
complexes
Zn(1)
Zn(2)
.
Compounds
bind
nanoparticle
surface
via
an
amine
group,
carbon‐carbon
triple
bond.
A
careful
photophysical
morphological
characterization
has
been
carried
out
samples,
interestingly,
observed
that
promote
assembly,
forming
luminescent
mesostructures.
Porphyrin
preferentially
organizes
by
end‐to‐end
whereas
porphyrin
does
not
confer
preferential
organization.
Biomimetics,
Год журнала:
2024,
Номер
9(3), С. 154 - 154
Опубликована: Март 1, 2024
The
incidence
of
microbial
infections
in
orthopedic
prosthetic
surgeries
is
a
perennial
problem
that
increases
morbidity
and
mortality,
representing
one
the
major
complications
such
medical
interventions.
emergence
novel
technologies,
especially
3D
printing,
represents
promising
avenue
development
for
reducing
risk
eventualities.
There
are
already
host
biomaterials,
suitable
being
tested
antimicrobial
properties
when
they
coated
with
bioactive
compounds,
as
antibiotics,
or
combined
hydrogels
antioxidant
properties,
chitosan
metal
nanoparticles,
among
others.
materials
discussed
context
this
paper
comprise
beta-tricalcium
phosphate
(β-TCP),
biphasic
calcium
(BCP),
hydroxyapatite,
lithium
disilicate
glass,
polyetheretherketone
(PEEK),
poly(propylene
fumarate)
(PPF),
poly(trimethylene
carbonate)
(PTMC),
zirconia.
While
recent
research
results
promising,
further
required
to
address
increasing
antibiotic
resistance
exhibited
by
several
common
pathogens,
potential
fungal
infections,
toxicity
some
nanoparticles.
Other
solutions,
like
incorporation
phytochemicals,
should
also
be
explored.
Incorporating
artificial
intelligence
(AI)
certain
implants
use
AI
against
bacterial
might
represent
viable
solutions
these
problems.
Finally,
there
legal
considerations
associated
biomaterials
widespread
which
must
taken
into
account.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
Physical Chemistry Chemical Physics,
Год журнала:
2024,
Номер
26(23), С. 16407 - 16437
Опубликована: Янв. 1, 2024
As
one
of
the
most
instrumental
components
in
architecture
advanced
nanomedicines,
plasmonic
nanostructures
(mainly
gold
and
silver
nanomaterials)
have
been
paid
a
lot
attention.
Nanoscale,
Год журнала:
2024,
Номер
16(27), С. 12750 - 12792
Опубликована: Янв. 1, 2024
Electrochemical
bio-sensing
is
a
potent
and
efficient
method
for
converting
various
biological
recognition
events
into
voltage,
current,
impedance
electrical
signals.
Biochemical
sensors
are
now
common
part
of
medical
applications,
such
as
detecting
blood
glucose
levels,
food
pathogens,
specific
cancers.
As
an
exciting
feature,
bio-affinity
couples,
proteins
with
aptamers,
ligands,
paired
nucleotides,
antibodies
antigens,
commonly
used
bio-sensitive
elements
in
electrochemical
biosensors.
Biotin-avidin
interactions
have
been
utilized
purposes
recent
years,
targeting
drugs,
diagnosing
clinically,
labeling
immunologically,
biotechnology,
biomedical
engineering,
separating
or
purifying
biomolecular
compounds.
The
interaction
between
biotin
avidin
widely
regarded
one
the
most
robust
reliable
noncovalent
due
to
its
high
bi-affinity
ability
remain
selective
accurate
under
reaction
conditions
bio-molecular
attachments.
More
recently,
there
numerous
attempts
develop
sense
circulating
cancer
cells
measurement
intracellular
levels
protein
thiols,
formaldehyde,
vitamin-targeted
polymers,
huwentoxin-I,
anti-human
antibodies,
variety
tumor
markers
(including
alpha-fetoprotein,
epidermal
growth
factor
receptor,
prostate-specific
Ag,
carcinoembryonic
antigen
125,
15-3,
etc.).
Still,
non-specific
binding
endogenous
biotin-binding
present
samples
can
result
false-positive
signals
hinder
detection
biomarkers.
This
review
summarizes
categories
biotin-functional
nanoparticles
designed
detect
biomarkers
highlights
some
challenges
using
them
diagnostic
tools.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(10), С. 291 - 291
Опубликована: Сен. 30, 2024
Gold
nanoparticles
(AuNPs)
have
gained
significant
attention
in
the
biomedical
field
owing
to
their
versatile
properties.
AuNPs
can
be
customized
by
modifying
size,
shape
and
surface
characteristics.
In
recent
years,
extensive
research
has
explored
integration
of
into
various
dental
materials,
including
titanium,
polymethylmethacrylate
(PMMA)
resin
composites.
This
review
aims
summarize
advancements
application
modified
materials
assess
effects
on
related
cellular
processes
field.
Relevant
articles
published
English
association
with
were
identified
through
a
systematic
search
PubMed/MEDLINE,
Embase,
Scopus
ScienceDirect
databases
from
January
2014
April
2024.
Future
prospects
for
utilization
dentistry
are
surveyed.
