Abstract
In
this
study,
we
aim
to
investigate
the
family
of
porphyrins
from
a
novel
perspective.
particular,
focus
on
their
role
in
controlling
assembly
gold
nanorods
(AuNRs)
through
synthetic
approach.
Using
seed‐mediated
growth
method,
AuNRs
were
first
synthesized.
Then,
surfaces
functionalized
with
four
different
types
explore
unique
influence
process.
Two
pairs
synthesized:
metal‐free
1
and
2
two
corresponding
zinc
complexes
Zn(1)
Zn(2)
.
Compounds
bind
nanoparticle
surface
via
an
amine
group,
carbon‐carbon
triple
bond.
A
careful
photophysical
morphological
characterization
has
been
carried
out
samples,
interestingly,
observed
that
promote
assembly,
forming
luminescent
mesostructures.
Porphyrin
preferentially
organizes
by
end‐to‐end
whereas
porphyrin
does
not
confer
preferential
organization.
RSC Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Organometallic
complexes
offer
a
wide
range
of
properties
like
structural
variety,
reaction
kinetics,
tunable
lipophilicity
and
alternate
mechanisms
activation
under
physiological
conditions
compared
to
platinum
chemotherapeutics
are
thus...
Materials Advances,
Год журнала:
2024,
Номер
5(20), С. 8007 - 8016
Опубликована: Янв. 1, 2024
Synthesis
of
biocompatible
nanocomposite
with
AuNS,
CS
and
bPEI
as
a
universal
non-viral
gene
delivery
nanocarrier
for
targeted
therapeutic
RNA
DNA
to
cells.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(9), С. 5977 - 5991
Опубликована: Авг. 9, 2024
This
study
describes
a
multifunctional
nanoparticle
platform
for
targeted
CT
imaging
and
therapy
of
cancers.
Pemetrexed
(conjugated
with
polyethylene
glycol,
MW
2000
Da)
polyNIPAM
(PEGylated)
were
designed
delivery
to
folate
receptors
thermally
ablated
tumors,
respectively.
These
moieties
coated
on
gold
nanoparticles
(7
30
nm),
the
prepared
compounds
characterized
using
Nanotechnology Science and Applications,
Год журнала:
2024,
Номер
Volume 17, С. 189 - 210
Опубликована: Сен. 1, 2024
Breast
cancer
is
a
significant
global
health
issue,
contributing
to
15%
of
cancer-related
deaths.
Our
laboratory
has
pioneered
novel
approach,
combining
Ayurvedic
principles
with
green
nanotechnology,
develop
scientifically
rigorous
medical
modality
referred
as
Nano-Ayurvedic
Medicine,
recently
approved
by
the
US
Patents
and
Trademarks
Office.
Here
in
we
report
new
medicine
agent
derived
from
gold
nanoparticles
encapsulated
phytochemicals
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(21), С. 5162 - 5170
Опубликована: Янв. 1, 2024
Au(III)
is
highly
reactive.
At
odds
with
its
reduced
counterpart,
Au(I),
it
hardly
present
in
structural
databases.
And
yet,
the
starting
reactant
to
form
gold
nanoclusters
(AuNCs)
and
constitutive
component
of
a
new
class
drugs.
Its
reactivity
world
apart
from
that
iso-electronic
Pt(II)
species.
Rather
than
DNA,
targets
proteins.
interaction
amino
acid
residues
manifold.
It
can
strongly
interact
residue
backbones,
side
chains
protein
ends,
appropriate
complexes
whose
stabilization
energy
reaches
up
more
40
kcal
mol-1,
affect
pKa
residues,
promote
charge
transfer
amount
reduced.
Here,
quantum
chemical
calculations
provide
quantitative
information
on
all
processes
where
be
involved.
A
myriad
arrangements
are
examined
order
determine
strongest
interactions
quantify
between
protonated
deprotonated
Au(III).
The
calculated
energies
quantitatively
reproduce
experimental
tendency
selenocysteine,
cysteine
histidine
negatively
charged
acids
such
as
Glu
Asp.
Also,
aromatic
tyrosine
tryptophan
In
proteins,
basic
pH
plays
role
deprotonation
cysteine,
lysine
increases
binding
affinity
toward
these
acids.
also
trigger
reduction
ions.
Sulfur-containing
(cysteine
methionine)
selenocysteine
almost
one
electron
upon
binding.
Tyrosine
shows
considerable
act
reductant.
Other
acids,
commonly
identified
Au-protein
adducts,
Ser,
Trp,
Thr,
Gln,
Glu,
Asn,
Asp,
Lys,
Arg
His,
possess
notable
reducing
power
These
results
their
discussion
vade
mecum
find
application
medicinal
chemistry
nanotech
applications
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 21, 2024
Abstract
The
anticancer
efficacy
of
doxorubicin,
an
anthracycline‐based
and
FDA‐approved
chemotherapeutic
drug,
is
significantly
hindered
by
acquired
chemoresistance
severe
side
effects
despite
its
potent
properties.
To
overcome
these
challenges,
we
developed
innovative
therapeutic
formulation
that
integrates
targeted
chemotherapy
phototherapy
within
a
single
platform
using
gold
nanoparticles
(AuNPs).
This
novel
nanoconjugate,
designated
as
Dox‐Fe@FA‐AuNPs
,
co‐functionalized
with
folic
acid,
iron(III)‐phenolate/carboxylate
complex,
enabling
cancer‐specific
drug
activation.
Here,
report
the
synthesis,
characterization,
comprehensive
physico‐chemical
biological
evaluations
.
nanoconjugate
exhibited
excellent
solubility,
stability,
enhanced
cellular
uptake
in
folate
receptor‐positive
cancer
cells.
was
potently
cytotoxic
against
HeLa
MDA‐MB‐231
cells
(HeLa:
105.5±16.52
μg
mL
−1
;
MDA‐MB‐231:
112.0±12.31
(3D):
156.31±19.35
)
while
less
to
folate(−)
(MCF‐7,
A549
HepG2).
cytotoxicity
attributed
pH‐dependent
release
which
preferentially
occurs
acidic
tumor
microenvironment.
Additionally,
under
red
light
irradiation,
generated
ROS,
inducing
caspase‐3/7‐dependent
apoptosis
photo‐index
(PI)
>50,
inhibited
cell
migration.
Our
findings
underscore
potential
highly
effective
sustainable
for
chemo‐phototherapy.
Abstract
In
this
study,
we
aim
to
investigate
the
family
of
porphyrins
from
a
novel
perspective.
particular,
focus
on
their
role
in
controlling
assembly
gold
nanorods
(AuNRs)
through
synthetic
approach.
Using
seed‐mediated
growth
method,
AuNRs
were
first
synthesized.
Then,
surfaces
functionalized
with
four
different
types
explore
unique
influence
process.
Two
pairs
synthesized:
metal‐free
1
and
2
two
corresponding
zinc
complexes
Zn(1)
Zn(2)
.
Compounds
bind
nanoparticle
surface
via
an
amine
group,
carbon‐carbon
triple
bond.
A
careful
photophysical
morphological
characterization
has
been
carried
out
samples,
interestingly,
observed
that
promote
assembly,
forming
luminescent
mesostructures.
Porphyrin
preferentially
organizes
by
end‐to‐end
whereas
porphyrin
does
not
confer
preferential
organization.
