Study of Manipulative In Situ Pore‐Formation upon Polymeric Coating on Cylindrical Substrate for Sustained Drug Delivery DOI
Hao Wei,

Ping Lin,

Baozhang Shi

и другие.

Macromolecular Bioscience, Год журнала: 2024, Номер unknown

Опубликована: Июль 22, 2024

Abstract Herein, the micro‐porous polylactic acid coating applied on surface of cylindrical substrate is fabricated by a novel in situ pore‐formation strategy based combinational effect breath figure (BF) and vapor‐induced phase separation (VIPS) processes. Under condition high environmental humidity, solvent pair chloroform dimethylformamide employed for post‐treatment onto pre‐formed PLA to induce following mechanism BF VIPS, respectively. A composite porous structure with both cellular‐like bi‐continuous network morphologies obtained. By tunning experimental factors including ratio pair, temperature, morphological manipulation upon pore morphology can be facilely achieved control transition between VIPS. Paclitaxel used as model drug loaded into wicking post‐immersion. Coatings different features show varying loading release capacities. The 28‐day test reveals dynamic profiles samples, total rate ranging from 35.70% 79.96%. Optimal capacity 19.28 µg cm −2 are BF‐VIPS structure. This research established cost‐efficient flexibility structural concerning construction drug‐eluting feature manipulative delivery.

Язык: Английский

Digital Light Processing 3D Printing Technology in Biomedical Engineering: A Review DOI
X. Chang,

jinpeng Liu,

Jia‐Qi Lü

и другие.

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract As one of the 3D printing technologies, digital light processing (DLP) technology has been widely applied in biomedical engineering. The principles and advantages DLP are compared with other while characteristics applicable fields each technique analyzed. applications tissue engineering, medical devices pharmaceutical field classified summarized. Besides, prospects challenges engineering discussed. With continuous advancement, will play an increasingly important role personalized medicine regenerative medicine.

Язык: Английский

Процитировано

0
Harnessing innovation in microneedle technology for Women's healthcare DOI

Yu Ting He,

Xin Yao Geng,

Mona Chang

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113706 - 113706

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Study of Manipulative In Situ Pore‐Formation upon Polymeric Coating on Cylindrical Substrate for Sustained Drug Delivery DOI
Hao Wei,

Ping Lin,

Baozhang Shi

и другие.

Macromolecular Bioscience, Год журнала: 2024, Номер unknown

Опубликована: Июль 22, 2024

Abstract Herein, the micro‐porous polylactic acid coating applied on surface of cylindrical substrate is fabricated by a novel in situ pore‐formation strategy based combinational effect breath figure (BF) and vapor‐induced phase separation (VIPS) processes. Under condition high environmental humidity, solvent pair chloroform dimethylformamide employed for post‐treatment onto pre‐formed PLA to induce following mechanism BF VIPS, respectively. A composite porous structure with both cellular‐like bi‐continuous network morphologies obtained. By tunning experimental factors including ratio pair, temperature, morphological manipulation upon pore morphology can be facilely achieved control transition between VIPS. Paclitaxel used as model drug loaded into wicking post‐immersion. Coatings different features show varying loading release capacities. The 28‐day test reveals dynamic profiles samples, total rate ranging from 35.70% 79.96%. Optimal capacity 19.28 µg cm −2 are BF‐VIPS structure. This research established cost‐efficient flexibility structural concerning construction drug‐eluting feature manipulative delivery.

Язык: Английский

Процитировано

1