International Immunopharmacology, Год журнала: 2024, Номер 145, С. 113784 - 113784
Опубликована: Дек. 12, 2024
Язык: Английский
Progress in Biomedical Engineering, Год журнала: 2025, Номер 7(2), С. 022004 - 022004
Опубликована: Фев. 5, 2025
Abstract The issue of antibiotic resistance is increasing with time because the quick rise microbial strains. Overuse antibiotics has led to multidrug-resistant, pan-drug-resistant, and extensively drug-resistant bacterial strains, which have worsened situation. Different techniques been considered applied combat this issue, such as developing new antibiotics, practicing stewardship, improving hygiene levels, controlling overuse. Vaccine development made a substantial contribution overcoming although it underestimated. In recent era, reverse vaccinology contributed different kinds vaccines against pathogens, revolutionizing vaccine process. Reverse helps prioritize better candidates by using various tools filter pathogen’s complete genome. review, we will shed light on computational designing, immunoinformatic tools, genomic proteomic data, challenges success stories designing.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 375 - 375
Опубликована: Март 15, 2025
Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions
Язык: Английский
Процитировано
1
Materials Today Bio, Год журнала: 2024, Номер 27, С. 101134 - 101134
Опубликована: Июнь 20, 2024
Biomimetic functionalized metal-organic frameworks (Fn-MOFs) represent a cutting-edge approach in the realm of cancer vaccines. These multifunctional agents, inspired by biological systems, offer unprecedented opportunities for development next-generation The vast surface area, tunable pore size, and diverse chemistry MOFs provide versatile scaffold encapsulation protection antigenic components, crucial vaccine stability delivery. This work delves into innovative design application Fn-MOFs, highlighting their role as carriers immune enhancement potential to revolutionize By mimicking natural processes, with ability be myriad chemical entities, exhibit superior biocompatibility stimuli-responsive behavior facilitate targeted delivery tumor sites. review encapsulates latest advancements Fn-MOF technology, from synthesis modification integration combination therapies. It underscores significance biomimetic approaches overcoming current challenges development, such antigen evasion. leveraging nature this paves way strategies vaccines, aiming induce potent long-lasting responses against malignancies.
Язык: Английский
Процитировано
5
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Abstract Muscle regeneration is a vital biological process that crucial for maintaining muscle function and integrity, particularly the treatment of diseases such as sarcopenia muscular dystrophy. Generally, tissues can self‐repair regenerate under various conditions, including acute or chronic injuries, aging, genetic mutation. However, becomes challenging beyond certain threshold, in severe injuries progressive diseases. In recent years, liposome‐based nanotechnologies have shown potential promising therapeutic strategies regeneration. Liposomes offer an adaptable platform targeted drug delivery due to their cell membrane‐like structure excellent biocompatibility. They enhance solubility, stability, while minimizing systemic side effects by different mechanisms. This review summarizes advancements, discusses current applications mechanisms, highlights challenges future directions possible clinical translation nanomaterials It hoped this offers new insights into development liposome‐enabled nanomedicine address limitations.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)
Опубликована: Авг. 23, 2024
Abstract Aluminum adjuvants remain the most commonly used vaccine adjuvants. Being rather effective in triggering humoral immunity, however, aluminum usually show limited abilities activating cellular immunities. Herein, by adding manganese ions during preparation of adjuvant, a manganese‐modified (Mn‐Al) adjuvant is obtained, which can effectively stimulate both and immune responses. Such Mn‐Al enhance antigen adsorption promote internalization dendritic cells (DCs). Subsequently, released Mn 2+ activate cyclic guanosine monophosphate–adenosine monophosphate synthase‐stimulator interferon genes pathway to further DC activation. When combines with model ovalbumin (OVA), Mn‐Al‐adjuvantes induce high levels antigen‐specific antibody titers proportions cytotoxic T vivo. Moreover, Mn‐Al‐adjuvanted elicited stronger responses than high‐dose aluminum‐based adjuvant. Additionally, immunization mice OVA presence significantly inhibited growth B16‐OVA tumors. Furthermore, when formulated human papillomavirus antigens, vaccines better vivo vaccination performance aluminum‐adjuvanted vaccines. Therefore, may thus become new potential replace conventional
Язык: Английский
Процитировано
1
Israeli Journal of Aquaculture - Bamidgeh, Год журнала: 2024, Номер 76(2)
Опубликована: Июнь 21, 2024
Vaccination is an effective way to control many infectious diseases in fish. Israeli fish farming has successfully used two vaccines over the last 30 years and no problem with side effects of vaccination. However, after introducing new species, a emerged: these fish, vaccination, demonstrated peritoneal lesions such as granulomas. At same time, did not show retarded growth or suffering during fattening period. This study was conducted establish connection between vaccination appearance Evidence drawn from this research work comparing vaccinated non-vaccinated confirms that intraperitoneal granulomas do impact growth, performance, fillet quality at harvest.
Язык: Английский
Процитировано
0
Cell Reports Physical Science, Год журнала: 2024, Номер 5(7), С. 102081 - 102081
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
0
Vaccines, Год журнала: 2024, Номер 12(10), С. 1187 - 1187
Опубликована: Окт. 18, 2024
Aluminum adjuvants, renowned for their safety and efficacy, act as excellent adsorbents vaccine immunogen enhancers, significantly contributing to innate, endogenous, humoral immunity. An ideal adjuvant not only boosts the immune response but also ensures optimal protective adjuvants are most widely used have played a crucial role in both prevention of existing diseases development new vaccines. With increasing emergence vaccines, traditional continually being researched upgraded. The future lies exploration integration novel technologies that surpass capabilities aluminum adjuvants. One promising direction is incorporation nanoparticles, which offer precise delivery controlled release antigens, thereby enhancing overall response.
Язык: Английский
Процитировано
0