A mussel-inspired wet-adhesive prolonged-acting antibacterial hydrogels for the treatment of periodontitis

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161262 - 161262

Опубликована: Март 1, 2025

Язык: Английский

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Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

International Journal of Oral Science, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 17, 2025

Abstract Complement C3 plays a critical role in periodontitis. However, its source, and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that is primarily derived periodontal fibroblasts. Subsequently, demonstrated C3a has detrimental effect ligature-induced C3ar −/− mice exhibited significantly less destruction support tissues compared to wild-type mice, characterized mild gingival tissue damage reduced alveolar bone loss. This reduction was associated with decreased production pro-inflammatory mediators osteoclast infiltration the tissues. Mechanistic studies suggested could promote macrophage polarization differentiation. Finally, patients found results observed were consistent human data. Therefore, findings clearly demonstrate destructive fibroblast-derived driven M1 These strongly feasibility C3a-targeted interventions for treatment

Язык: Английский

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Fibroblasts derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Complement C3 plays a critical role in periodontitis. However, its source, and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that is primarily derived periodontal fibroblasts. Subsequently, demonstrated C3a has detrimental effect ligature-induced C3ar-/- mice exhibited significantly less destruction support tissues compared to wild-type mice, characterized mild gingival tissue damage reduced alveolar bone loss. This reduction was associated with decreased production pro-inflammatory mediators osteoclast infiltration the tissues. Mechanistic studies suggested could promote macrophage polarization differentiation. Finally, patients found results observed were consistent human data. Therefore, findings clearly demonstrate destructive fibroblast-derived driven M1 These strongly feasibility C3a-targeted interventions for treatment

Язык: Английский

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A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment

Biomaterials, Год журнала: 2024, Номер 316, С. 123024 - 123024

Опубликована: Дек. 16, 2024

Язык: Английский

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