Highly Efficient Aggregation‐Induced Chiral TADF Molecules Exhibiting Prolonged Lifetime in Living Cells under Hypoxic Stress DOI

Danfeng Ye,

Guangrong Zheng, Amjad Ali

и другие.

Advanced Optical Materials, Год журнала: 2024, Номер 12(36)

Опубликована: Ноя. 18, 2024

Abstract Thermally activated delayed fluorescence (TADF) materials have garnered significant attention as potential candidates for biological photoluminescence imaging. However, the achievement of tunable chiral TADF through aggregated and self‐assembled processes remains a formidable challenge. In this study, four donor–acceptor–donor type molecules, designed by directly linking electron‐donating moieties (phenoxazine, phenothiazine or 1‐phenyl‐1,2,3,4‐tetrahydroisoquinoline) with an electron‐acceptor unit (diphenyl sulfone), promising luminescent imaging applications are presented. The experimental investigation reveals that these possess remarkably small Δ E ST values, promoting efficient reverse intersystem crossing (RISC). Additionally, they exhibit aggregation‐induced emission long‐delayed lifetimes affected state. Moreover, deoxygenation significantly enhances emission, enabling high‐contrast hypoxia probing, which shows great in living cells. This work not only offers molecular design strategy but also extends diverse detection field.

Язык: Английский

Expanding Our Horizons: AIE Materials in Bacterial Research DOI
Michelle M. S. Lee, Eric Y. Yu,

Joe H. C. Chau

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.

Язык: Английский

Процитировано

9
A pH‐Responsive, Surface Charge‐Switchable Nanosystem with Enhanced Biofilm Penetration for Synergistic Photodynamic and Antibiotic Therapy of Diabetic Wounds DOI Open Access

Zhencheng Sun,

Minghui Xiao,

Shuyi Lv

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 29, 2024

Abstract Chronic wounds, particularly those associated with diabetes, pose a significant clinical challenge due to their tendency develop biofilms that resist conventional antibiotic treatments. To address this issue, novel therapeutic strategy utilizing pH‐responsive nanoparticles loaded aggregation‐induced emission photosensitizers and natural saturated fatty acids (AIE/LA@HMONs−PyB) for effective biofilm penetration disruption is proposed. Under physiological conditions, AIE/LA@HMONs−PyB are negatively charged. Upon accumulation at infected sites, however, the pyridine betaine group on surface of enables rapid protonation charge reversal in acidic microenvironment, thereby enhancing ability penetrate biofilm. light irradiation, these generate reactive oxygen species effectively disrupt structure. This process synergistic action ciprofloxacin lower concentration, achieving an exceptional vitro antibacterial efficiency 99.99% against methicillin‐resistant Staphylococcus aureus ( S. ) biofilms. Furthermore, vivo diabetic wound model, therapy accelerates healing by reducing inflammation, promoting angiogenesis, collagen regeneration. The enhanced significantly improves efficacy combined approach, offering great promise advancing chronic patient outcomes.

Язык: Английский

Процитировано

3
Highly Efficient Aggregation‐Induced Chiral TADF Molecules Exhibiting Prolonged Lifetime in Living Cells under Hypoxic Stress DOI

Danfeng Ye,

Guangrong Zheng, Amjad Ali

и другие.

Advanced Optical Materials, Год журнала: 2024, Номер 12(36)

Опубликована: Ноя. 18, 2024

Abstract Thermally activated delayed fluorescence (TADF) materials have garnered significant attention as potential candidates for biological photoluminescence imaging. However, the achievement of tunable chiral TADF through aggregated and self‐assembled processes remains a formidable challenge. In this study, four donor–acceptor–donor type molecules, designed by directly linking electron‐donating moieties (phenoxazine, phenothiazine or 1‐phenyl‐1,2,3,4‐tetrahydroisoquinoline) with an electron‐acceptor unit (diphenyl sulfone), promising luminescent imaging applications are presented. The experimental investigation reveals that these possess remarkably small Δ E ST values, promoting efficient reverse intersystem crossing (RISC). Additionally, they exhibit aggregation‐induced emission long‐delayed lifetimes affected state. Moreover, deoxygenation significantly enhances emission, enabling high‐contrast hypoxia probing, which shows great in living cells. This work not only offers molecular design strategy but also extends diverse detection field.

Язык: Английский

Процитировано

0