Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions DOI Creative Commons
Najma Farahani, Mina Alimohammadi, Mehdi Raei

и другие.

Journal of Cell Communication and Signaling, Год журнала: 2024, Номер 18(4)

Опубликована: Ноя. 3, 2024

Abstract The endoplasmic reticulum (ER) is crucial for maintaining calcium balance, lipid biosynthesis, and protein folding. Disruptions in ER homeostasis, often due to the accumulation of misfolded or unfolded proteins, lead stress, which plays a significant role various diseases, especially cancer. Urological cancers, account high male mortality worldwide, pose persistent challenge their incurability tendency develop drug resistance. Among numerous dysregulated biological mechanisms, stress key factor progression treatment response these cancers. This review highlights dual aberrant activation urologic affecting both tumor growth therapeutic outcomes. While can support through pro‐survival autophagy, it primarily inhibits cancer via apoptosis pro‐death autophagy. Interestingly, paradoxically aid mechanisms such as exosome‐mediated immune evasion. Additionally, examines how pharmacological interventions, particularly with phytochemicals, stimulate stress‐mediated suppression. Key regulators, including PERK, IRE1α, ATF6, are discussed roles upregulating CHOP levels triggering apoptosis. In conclusion, deeper understanding urological cancers not only clarifies complex interactions between cellular but also provides new opportunities innovative strategies.

Язык: Английский

Local Temperature of Water Determined Based on Fluorescent Intensity Ratio of NaYF4:Er3+,Yb3+ Upconversion Nanoparticles DOI
Van Nghia Nguyen,

Duc Thien Trinh,

Nguyễn Đình Lâm

и другие.

Ceramics International, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Near-Infrared Light-Induced Deep Curing of Thiol–Epoxy Networks Based on Upconversion Photochemistry DOI Open Access

Pin Yang,

Yaoxin Huang,

Xiaoxuan Liu

и другие.

Coatings, Год журнала: 2025, Номер 15(4), С. 494 - 494

Опубликована: Апрель 21, 2025

Thiol–epoxy photopolymerization offers exceptional advantages for high-performance protective coatings, yet efficiently curing thick formulations remains a significant challenge due to the limited penetration depth of conventional UV light. Herein, we report novel near-infrared (NIR) light-activated system deep-curing applications, strategically integrating upconversion nanoparticles (UCNPs) as NIR-to-UV converters, isopropylthioxanthone (ITX) photosensitizer, and liquid N-phenylglycine-based photobase generator (NPG-TBD) with enhanced resin solubility. Upon 980 nm NIR irradiation, photogenerated TBD catalyzes thiol–epoxy polymerization through an anionic mechanism, enabling uniform network formation epoxy thiol functional group conversions greater than 90% throughout samples exceeding 2.5 cm in thickness. The resulting coatings exhibit excellent mechanical properties including 3H pencil hardness, strong adhesion (0 grade), good flexibility (2 mm), significantly outperforming systems approximately 1.5 mm. Additionally, cured materials demonstrate multifunctional characteristics distinctive luminescence dual-responsive shape memory behavior. This approach addresses critical limitations deep-photocuring technology while offering potential applications marine infrastructure, chemical storage facilities, smart requiring both substantial barrier programmable responsiveness.

Язык: Английский

Процитировано

0
Prominent Supramolecular Systems for Cancer Therapy: From Structural Design to Tailored Applications DOI
Jiawei Zhang, Qingya Zhang,

LI Xiao-jia

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117754 - 117754

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Mini crRNA-Mediated CRISPR/Cas12a System Enhanced Imaging of Multiple MicroRNAs in Cells DOI Creative Commons
Xiaolong Chen, Qianyi You, Yawen Guo

и другие.

Chemical & Biomedical Imaging, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

RNA imaging in live cells can provide comprehensive information on the expression, localization, degradation, storage, and regulation of cells, which is crucial for basic biology clinical research. Our previous research finds that slicing facilitated crRNA typical CRISPR/Cas12a system at a fitted site did not affect its trans-cleavage activity, was previously reported to be triggered by targeted ssDNA or dsDNA, mini crRNA-mediated (MCM-CRISPR/Cas12a) proposed. Here, we further apply it enhanced MicroRNAs designing activator as molecular beacon (MB), form hybrid double-stranded structure DNA/RNA with MicroRNA. When MicroRNA present, hairpin MB opened emits fluorescence. Simultaneously, DNA-RNA formed activates activity LbCas12a, partially cleaving single-stranded DNA extended from enhancing fluorescence intensity system. We designed MCM-CRISPR/Cas12a miRNA-21, miRNA-155, miRNA-10b successfully applied sensitive specific these both inside outside cells. This study provides new idea multiple within important studying distribution dynamic changes

Язык: Английский

Процитировано

1
Dopaminergic- and Serotonergic-Dependent Behaviors Are Altered by Lanthanide Series Metals in Caenorhabditis elegans DOI Creative Commons

Anthony Radzimirski,

Michael Croft,

Nicholas Ireland

и другие.

Toxics, Год журнала: 2024, Номер 12(10), С. 754 - 754

Опубликована: Окт. 17, 2024

The lanthanide series elements are transition metals used as critical components of electronics, well rechargeable batteries, fertilizers, antimicrobials, contrast agents for medical imaging, and diesel fuel additives. With the surge in their utilization, being found more our environment. However, little is known about health effects associated with exposure. Epidemiological studies performed rodents exposed to lanthanum (La) suggest neurological damage, learning memory impairment, disruption neurotransmitter signaling, particularly serotonin dopamine pathways. Unfortunately, heavier lanthanides. As dysfunctions serotonergic dopaminergic signaling implicated multiple conditions, including Parkinson’s disease, depression, generalized anxiety disorder, post-traumatic stress it utmost importance determine La other lanthanides on these systems. We therefore hypothesized that early-life exposure light [La (III) or cerium (Ce (III))] heavy [erbium (Er (III)) ytterbium (Yb Caenorhabditis elegans could cause dysregulation upon adulthood. Serotonergic was assessed by measuring pharyngeal pump rate, crawl-to-swim transition, egg-laying behaviors. Dopaminergic locomotor rate swim-to-crawl Treatment (III), Ce Er Yb caused deficits all assays, suggesting both disrupt Concomitant neurotransmission, four increased reactive oxygen species (ROS) generation decreased glutathione ATP levels. This suggests oxidative stress, which a modifier neurotransmission. Altogether, data may affect development pharmacological management related conditions.

Язык: Английский

Процитировано

0
Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions DOI Creative Commons
Najma Farahani, Mina Alimohammadi, Mehdi Raei

и другие.

Journal of Cell Communication and Signaling, Год журнала: 2024, Номер 18(4)

Опубликована: Ноя. 3, 2024

Abstract The endoplasmic reticulum (ER) is crucial for maintaining calcium balance, lipid biosynthesis, and protein folding. Disruptions in ER homeostasis, often due to the accumulation of misfolded or unfolded proteins, lead stress, which plays a significant role various diseases, especially cancer. Urological cancers, account high male mortality worldwide, pose persistent challenge their incurability tendency develop drug resistance. Among numerous dysregulated biological mechanisms, stress key factor progression treatment response these cancers. This review highlights dual aberrant activation urologic affecting both tumor growth therapeutic outcomes. While can support through pro‐survival autophagy, it primarily inhibits cancer via apoptosis pro‐death autophagy. Interestingly, paradoxically aid mechanisms such as exosome‐mediated immune evasion. Additionally, examines how pharmacological interventions, particularly with phytochemicals, stimulate stress‐mediated suppression. Key regulators, including PERK, IRE1α, ATF6, are discussed roles upregulating CHOP levels triggering apoptosis. In conclusion, deeper understanding urological cancers not only clarifies complex interactions between cellular but also provides new opportunities innovative strategies.

Язык: Английский

Процитировано

0