Development and Characterization of Biocompatible Chitosan-Aloe Vera Films Functionalized with Gluconolactone and Sorbitol for Advanced Wound Healing Applications DOI Creative Commons

Beata Kaczmarek,

Patrycja Glajc,

Dorota Chmielniak

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Chitosan (CTS) has emerged as a promising biopolymer for wound healing due to its biocompatibility, biodegradability, and intrinsic bioactive properties. This study explores the development characterization of CTS-based films enhanced with natural agents, aloe vera (A), gluconolactone (GL), sorbitol (S), improve their mechanical, antimicrobial, regenerative performance potential use in advanced care. A series were fabricated varying concentrations A, GL, S, physicochemical, biological properties comprehensively evaluated. Fourier transform infrared (FTIR) spectroscopy atomic force microscopy (AFM) analysis revealed modifications film structure attributable these additives, influencing surface roughness, hydrophilicity, thermal stability. Biocidal assays confirmed antimicrobial activity, particularly containing GL A. Biodegradation studies demonstrated significant enhancement microbial decomposition films, while cytocompatibility tests minimal cytotoxic effects improved cellular response. research underscores combining CS S engineer multifunctional biomaterials tailored effectively tackling different phases process, offering sustainable biocompatible alternative clinical applications.

Язык: Английский

Development and Characterization of Biocompatible Chitosan-Aloe Vera Films Functionalized with Gluconolactone and Sorbitol for Advanced Wound Healing Applications DOI Creative Commons

Beata Kaczmarek,

Patrycja Glajc,

Dorota Chmielniak

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Chitosan (CTS) has emerged as a promising biopolymer for wound healing due to its biocompatibility, biodegradability, and intrinsic bioactive properties. This study explores the development characterization of CTS-based films enhanced with natural agents, aloe vera (A), gluconolactone (GL), sorbitol (S), improve their mechanical, antimicrobial, regenerative performance potential use in advanced care. A series were fabricated varying concentrations A, GL, S, physicochemical, biological properties comprehensively evaluated. Fourier transform infrared (FTIR) spectroscopy atomic force microscopy (AFM) analysis revealed modifications film structure attributable these additives, influencing surface roughness, hydrophilicity, thermal stability. Biocidal assays confirmed antimicrobial activity, particularly containing GL A. Biodegradation studies demonstrated significant enhancement microbial decomposition films, while cytocompatibility tests minimal cytotoxic effects improved cellular response. research underscores combining CS S engineer multifunctional biomaterials tailored effectively tackling different phases process, offering sustainable biocompatible alternative clinical applications.

Язык: Английский

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