Sulfoximine Aided Ru(II)-Catalyzed Asymmetric Double C(sp2)–H Hydroarylations of Olefins DOI
Somratan Sau, Koneti Kondalarao,

Paushali Naskar

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Presented here is a sulfoximine-directed Ru(II)-catalyzed asymmetric intramolecular double C(sp

Язык: Английский

H8‐BINOL‐Derived Chiral η6‐Benzene Ligands: New Opportunities for the Ruthenium‐Catalyzed Asymmetric C−H Activation DOI

Junxuan Li,

Guodong Wang,

Weicong Guo

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(31)

Опубликована: Апрель 29, 2024

Abstract Given the tremendous success of (p‐cymene)Ru II ‐catalyzed C−H activation over past 20 years, community has long been aware that development chiral η 6 ‐benzene (Ben) ligands should be a potent strategy for achieving attractive but incredibly underdeveloped ruthenium(II)‐catalyzed asymmetric activation. However, it rarely achieved due to severe difficulty in developing proper Ben ligands. In particular, designing by connecting benzene fragment framework including rings remained an unsolved challenge until this effort. Here we present novel class axially derived from readily available ( S )‐5,5′,6,6′,7,7′,8,8′‐octahydro‐1,1′‐bi‐2‐naphthol (( )‐H 8 ‐BINOL) 4–8 steps. Notably, when coordinated with ruthenium, such ligand containing three only forms one possible isomeric BenRu complexes. The related catalysts could effectively catalyze N‐sulfonyl ketimines alkynes, affording range spirocyclic sultams up 99 % yield >99 ee. These are expected find broad applications future.

Язык: Английский

Процитировано

5

Catalytic Asymmetric C–H Activation/Cyclization of Sulfoximines with Sulfoxonium Ylides by a Chiral η6-Benzene Ruthenium(II) Catalyst DOI
Huan Liu, Ji‐Jun Jiang, Jun Wang

и другие.

ACS Catalysis, Год журнала: 2024, Номер unknown, С. 17398 - 17404

Опубликована: Ноя. 12, 2024

Chiral η6-benzene ruthenium(II) (BenRuII)-catalyzed asymmetric C–H activations are challenging and rarely seen in the literature. Herein, activation/cyclization of sulfoximines with sulfoxonium ylides catalyzed by chiral BenRuII catalyst derived from (S)-H8–BINOL is described. It provides efficient access to various sulfur-chiral 1,2-benzothiazine 1-oxides high yields enantioselectivities (up 99% yield 98% ee). Kinetic resolution racemic was also feasible. The reaction mechanism studied tool H/D exchange kinetic isotope effect. metallacycle revealing origin induction prepared, characterized, proved effective for model reaction. This work demonstrates great potential catalysts activation.

Язык: Английский

Процитировано

5

Planar chiral arene ruthenium complexes derived from R-carvone DOI
Mikhail A. Boym, Roman A. Pototskiy, Evgeniya Podyacheva

и другие.

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Natural R -carvone was converted into ruthenium complexes with planar-chiral arene ligands. Similar to the classical [(cymene)RuCl 2 ] complex, they catalyse C–H activation reactions, albeit low stereoselectivity.

Язык: Английский

Процитировано

0

H8‐BINOL‐Derived Chiral η6‐Benzene Ligands: New Opportunities for the Ruthenium‐Catalyzed Asymmetric C−H Activation DOI

Junxuan Li,

Guodong Wang,

Weicong Guo

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(31)

Опубликована: Апрель 29, 2024

Abstract Given the tremendous success of (p‐cymene)Ru II ‐catalyzed C−H activation over past 20 years, community has long been aware that development chiral η 6 ‐benzene (Ben) ligands should be a potent strategy for achieving attractive but incredibly underdeveloped ruthenium(II)‐catalyzed asymmetric activation. However, it rarely achieved due to severe difficulty in developing proper Ben ligands. In particular, designing by connecting benzene fragment framework including rings remained an unsolved challenge until this effort. Here we present novel class axially derived from readily available ( S )‐5,5′,6,6′,7,7′,8,8′‐octahydro‐1,1′‐bi‐2‐naphthol (( )‐H 8 ‐BINOL) 4–8 steps. Notably, when coordinated with ruthenium, such ligand containing three only forms one possible isomeric BenRu complexes. The related catalysts could effectively catalyze N‐sulfonyl ketimines alkynes, affording range spirocyclic sultams up 99 % yield >99 ee. These are expected find broad applications future.

Язык: Английский

Процитировано

0

Sulfoximine Aided Ru(II)-Catalyzed Asymmetric Double C(sp2)–H Hydroarylations of Olefins DOI
Somratan Sau, Koneti Kondalarao,

Paushali Naskar

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Presented here is a sulfoximine-directed Ru(II)-catalyzed asymmetric intramolecular double C(sp

Язык: Английский

Процитировано

0