Copper-catalyzed yne-allylic substitutions: concept and recent developments

Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 2739 - 2775

Опубликована: Окт. 31, 2024

The catalytic (asymmetric) allylation and propargylation have been established as powerful strategies allowing access to enantioenriched α-chiral alkenes alkynes. In this context, combining allylic propargylic substitutions offers new opportunities expand the scope of transition metal-catalyzed substitution reactions. Since its discovery in 2022, copper-catalyzed yne-allylic has undergone rapid development significant progress made using key copper vinyl allenylidene intermediates. This review summarizes developments illustrates influences salt, ligand, pattern substrate on regioselectivity stereoselectivity.

Язык: Английский

Enantioselective Propargylic Substitution Reactions via Transition Metal–Allenylidene Complexes as Key Intermediates

Coordination chemistry research., Год журнала: 2024, Номер unknown, С. 100003 - 100003

Опубликована: Дек. 1, 2024

Язык: Английский