Continuous manufacturing based paradigm shift in pharmaceuticals production and current regulatory framework
Kardile Punam Kashinath,
Lohare Rahul Sanjay,
Makka Krupali Ashokbhai
и другие.
Process Safety and Environmental Protection,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Combination of photocatalytic proton-coupled electron transfer and spin-center shift: direct C-H benzylation of N-heteroarenes with benzaldehydes in continuous-flow
Jia-Cheng Hou,
Jun Jiang,
Hui Dai
и другие.
Science China Chemistry,
Год журнала:
2025,
Номер
68(5), С. 1945 - 1951
Опубликована: Фев. 24, 2025
Язык: Английский
Self-Optimizing Bayesian for Continuous Flow Synthesis Process
Digital Discovery,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
Bayesian
algorithm
with
self-optimizing
capabilities,
tailored
for
process
optimization
in
continuous
flow
synthesis
small
datasets
enhancing
efficiency.
Язык: Английский
Enhancing Efficiency and Sustainability: Unleashing the Potential of Continuous Flow in Multicomponent Reactions
ChemSusChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 11, 2024
The
integration
of
multicomponent
reactions
(MCRs),
which
offer
a
rapid
and
efficient
approach
to
synthesize
complex
molecular
scaffolds,
with
continuous
flow
platforms
is
an
increasingly
recognized
strategy
in
green
synthesis.
This
association
enables
precise
control
over
reaction
parameters,
including
improved
kinetics
selectivity,
reduced
times,
enhanced
yields
scalabilities,
while
aligning
sustainable
chemistry
principles
through
resource
utilization,
minimized
waste,
environmental
impact.
review
presents
critical
analysis
recent
studies
covering
the
MCR-continuous
association,
focus
on
achieving
greener
more
synthesis
practices.
Язык: Английский
Continuous‐Flow Photochemistry: The Synthesis of Marketed Pharmaceutical Compounds
ChemistrySelect,
Год журнала:
2024,
Номер
9(47)
Опубликована: Дек. 1, 2024
Abstract
Chemistry
professionals
from
all
kinds
of
fields
and
disciplines
in
the
academic
commercial
sectors
have
recently
shown
a
great
deal
interest
continuous‐flow
chemistry.
Flow
methods
are
used
nowadays
for
rapid
optimization
assessment,
as
well
production
scale‐up,
reaction
discovery,
methodology.
Photochemical
processes
currently
receiving
lot
attention
scientific
community,
application
flow
these
approaches
has
advantages
chemistry
its
importance
modern
industry
worldwide.
This
study
illustrates
most
recent
advancements
benefits
continuous
photochemical
reactions
relation
to
synthesis
active
pharmaceutical
compounds
recommended
frameworks.
Язык: Английский
Photochemically Induced Approaches to the Syntheses of β‐Lactams
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(22), С. 4548 - 4558
Опубликована: Окт. 8, 2024
Abstract
The
synthesis
of
β‐lactam
scaffolds
is
paramount
importance
due
to
their
extensive
applications
in
pharmaceuticals,
particularly
as
antibiotics.
Visible
light
photocatalysis
has
emerged
a
revolutionary
approach
this
domain,
providing
sustainable
and
efficient
pathway
for
construction.
In
review,
we
meticulously
discuss
the
recent
developments
photocatalysed
frameworks.
A
key
focus
Staudinger
reaction,
traditionally
cornerstone
synthesis,
its
adaptation
visible
photocatalysis.
We
explore
mechanistic
intricacies
reaction
under
photochemical
conditions,
along
with
other
pivotal
cyclization
strategies
enabled
by
light.
By
illuminating
novel
photocatalytic
routes
β‐lactams,
review
provides
thorough
understanding
state‐of‐the‐art
techniques
sets
stage
future
innovations
green
these
critical
compounds.
Язык: Английский
Deep Neutral Network Enhanced Mesoscopic Thermodynamic Model for Unlocking the Electrode/Electrolyte Interface
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Structure
and
properties
of
the
electrode/electrolyte
interface
significantly
influence
electrochemical
processes
energy
storage
conversion,
yet
challenge
lies
in
accurate
description
both
molecular
characteristics
external
field
effects.
Here,
we
develop
a
mesoscopic
thermodynamic
model
that
calculates
electrolytes
based
on
chemical
potential,
its
efficiency
is
enhanced
by
deep
neural
network.
The
network
(DeepMT)
effectively
bridges
gap
between
micro-level
ions
macro-level
effects
field,
enabling
precise
presentation
ion
density
distributions
over
complex
conditions.
Our
result
indicates
DeepMT
not
only
demonstrates
computational
improvement
approximately
four
orders
magnitude
direct
theoretical
calculations,
but
also
accurately
predicts
including
adsorption,
surface
charge,
differential
capacitance
through
statistical
analysis
distributions.
Язык: Английский
Batch and Continuous Flow Total Synthesis of Cannabidiol
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(20)
Опубликована: Июль 23, 2024
Abstract
Herein,
we
present
a
comprehensive
total
synthesis
of
cannabidiol
integrating
both
batch
and
continuous
flow
conditions.
Our
approach
is
planned
to
streamline
the
olivetolic
acid
derivatives
utilize
an
enantiomerically
pure
monoterpene
moiety
obtained
from
naturally
occurring
(
R
)‐(+)‐limonene
by
photocatalysis.
Key
reactions,
including
ester
Friedel‐Crafts
alkylation,
are
successfully
adapted
flow,
resulting
in
improved
yields
selectivities.
This
study
not
only
offers
scalable
efficient
route
for
but
also
contributes
synthetic
approaches
access
cannabinoids
(diversity
synthesis),
with
potential
applications
medicinal
industrial
contexts.
Язык: Английский
Deep Neutral Network Enhanced Mesoscopic Thermodynamic Model for Unlocking the Electrode/Electrolyte Interface
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Structure
and
properties
of
the
electrode/electrolyte
interface
significantly
influence
electrochemical
processes
energy
storage
conversion,
yet
challenge
lies
in
accurate
description
both
molecular
characteristics
external
field
effects.
Here,
we
develop
a
mesoscopic
thermodynamic
model
that
calculates
electrolytes
based
on
chemical
potential,
its
efficiency
is
enhanced
by
deep
neural
network.
The
network
(DeepMT)
effectively
bridges
gap
between
micro‐level
ions
macro‐level
effects
field,
enabling
precise
presentation
ion
density
distributions
over
complex
conditions.
Our
result
indicates
DeepMT
not
only
demonstrates
computational
improvement
approximately
four
orders
magnitude
direct
theoretical
calculations,
but
also
accurately
predicts
including
adsorption,
surface
charge,
differential
capacitance
through
statistical
analysis
distributions.
Язык: Английский
Two-Step Continuous Synthesis of Cabozantinib in a Microreactor: Mechanism and Kinetics Research of EDCI/HOBt-Mediated Amidation
Industrial & Engineering Chemistry Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Cabozantinib
(CBT)
is
a
small-molecule
pharmaceutical
approved
for
the
treatment
of
medullary
thyroid
cancer,
advanced
renal
cell
carcinoma,
and
hepatocellular
carcinoma.
The
two-step
amidation
starting
with
1,1-cyclopropanedicarboxylic
acid
(CBT-1)
large-scale
synthetic
route
CBT,
but
existing
processes
suffered
from
highly
toxic
reagents,
low
yields,
long
reaction
times.
In
this
work,
cascaded
flow
process
was
developed
to
synthesize
CBT
in
microreactor.
first
step,
CDI
determined
as
coupling
reagent
generate
1-(4-fluorophenylaminoformyl)
cyclopropane
carboxylic
(CBT-3)
yield
97.5%
after
optimizing
operating
conditions.
Then,
EDCI/HOBt
were
screened
reagents
obtain
second
possible
paths
intrinsic
kinetics
revealed
result
indicated
that
formation
ion
pairs
between
CBT-3
EDCI
rate-determining
step
whole
process.
end,
two
reactions
microreactor,
synthesized
total
96.1%
35
min.
scale-up
microchemical
system
showed
productivity
can
achieve
about
5.3
g/h.
Compared
processes,
milder
reagents/conditions
used,
innovative
approach
continuous
synthesis
provide
an
efficient
alternative
method
production
CBT.
Язык: Английский