Implications of liquid-liquid phase separation and ferroptosis in Alzheimer's disease DOI
Fu-Wei Wang, Zihao Chen, Qiong Zhou

и другие.

Neuropharmacology, Год журнала: 2024, Номер 259, С. 110083 - 110083

Опубликована: Июль 21, 2024

Язык: Английский

Ginger leaf polyphenols mitigate β-amyloid toxicity via JNK/FOXO pathway activation in Caenorhabditis elegans DOI
Tao Gao,

Ningning Yan,

Y. N. Pu

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Ginger leaf polyphenols (GLP) alleviated β-amyloid toxicity by activating the JNK/FOXO signaling pathway in Caenorhabditis elegans .

Язык: Английский

Процитировано

1
Tannic acid as a biphasic modulator of tau protein liquid–liquid phase separation DOI

Jiani Xiang,

Jingxin Chen,

Yanqing Liu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133578 - 133578

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

3
The Role of Liquid‒Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases DOI Creative Commons
Xingyu Lu,

Jiongtong Lu,

Shengnan Li

и другие.

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

It is widely accepted that living organisms form highly dynamic membrane-less organelles (MLOS) with various functions through phase separation, and the indispensable role separation plays in mechanisms of normal physiological pathogenesis gradually becoming clearer. Pathological aggregates, regarded as hallmarks neurodegenerative diseases, have been revealed to be closely related aberrant separation. Specific proteins are assembled into condensates transform insoluble inclusions contributing development diseases. In this review, we present an overview progress research, involving its biological status research focusing on five main disease-specific proteins, tau, TDP-43, FUS, α-Syn HTT, how exactly these reside within liquid-like compartments thus turn solid deposits. Further studies will yield new perspectives for understanding aggregation potential therapeutic strategies, future directions anticipated.

Язык: Английский

Процитировано

2
Liquid–liquid phase separation of Tau and α-synuclein: a new target for treating comorbidity in neurodegeneration DOI
Nahuel N. Foressi, Leandro Cruz Rodríguez, M. Soledad Celej

и другие.

Biophysical Reviews, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Язык: Английский

Процитировано

2
Ultrasmall iron-gallic acid coordination polymer nanoparticles for scavenging ROS and suppressing inflammation in tauopathy-induced Alzheimer’s disease DOI

Jiani Huang,

Fei Wu,

Wenzhao Cao

и другие.

Biomaterials, Год журнала: 2024, Номер 317, С. 123042 - 123042

Опубликована: Дек. 22, 2024

Язык: Английский

Процитировано

2
Implications of liquid-liquid phase separation and ferroptosis in Alzheimer's disease DOI
Fu-Wei Wang, Zihao Chen, Qiong Zhou

и другие.

Neuropharmacology, Год журнала: 2024, Номер 259, С. 110083 - 110083

Опубликована: Июль 21, 2024

Язык: Английский

Процитировано

1