Stereoselective Synthesis of Atropisomeric Amides Enabled by Intramolecular Acyl Transfer
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
stereoselective
strategy
to
make
C–N
atropisomeric
amides
based
on
intramolecular
acyl
transfer
via
a
tethered
Lewis
basic
pyridine
or
tertiary
amine
group
is
reported.
Язык: Английский
Synthesis and Elaboration of Medium-Sized Ring Building Blocks Prepared via Cascade Ring Expansion Reactions
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
A
general
approach
is
described
for
the
synthesis
and
elaboration
of
medium-sized
ring
mono-
difunctionalized
8-
or
9-membered
lactone
building
blocks.
The
lactones
are
prepared
via
cascade
expansion
reactions
elaborated
Suzuki-Miyaura
cross
coupling
various
N-functionalization
reactions.
This
enables
efficient
access
to
diverse,
blocks
in
a
synthetically
challenging
under-represented
area
pharmaceutical
chemical
space.
Язык: Английский
Catalytic Construction of C(sp3)‐Ge Bonds: Recent Advances and Future Perspectives
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(22), С. 4618 - 4633
Опубликована: Окт. 16, 2024
Abstract
Germanium
(Ge),
a
congener
of
carbon,
possesses
unique
properties
that
hold
extensive
potential
for
applications
across
multiple
domains.
Recent
years
have
seen
significant
progress
in
the
development
carbon‐germanium
bond
formation
strategies,
particularly
those
more
challenging
C(
sp
3
)−Ge
bonds.
This
review
systematically
summarizes
recent
advances
forming
methodologies,
with
particular
emphasis
on
(1)
versatility
transition‐metals,
including
iron,
nickel,
copper,
rhodium
and
palladium,
as
catalysts
broadening
reaction
scope
controlling
selectivity;
(2)
powerfulness
organic
photocatalysis
achieving
mild
selective
formation,
(3)
sustainability
catalytic
electrosynthesis
facilitating
chemical
oxidant‐/reductant‐
free
conversions.
Additionally,
examples
(4)
non‐catalytic
strategies
are
also
discussed.
The
representative
scopes,
well
mechanistic
proposals,
these
protocols
highlighted.
Through
an
overview
current
state
research,
this
aims
to
offer
insights
into
construction
bonds,
provide
perspectives
future
research
directions
address
challenges.
Язык: Английский
Cyclic amine ring expansion
Nature Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Язык: Английский
Enantioselective Synthesis of Nonfused Eight-Membered O-Heterocycles by Sequential Catalysis
Organic Letters,
Год журнала:
2024,
Номер
27(1), С. 340 - 345
Опубликована: Дек. 30, 2024
This
work
describes
a
chiral
bifunctional
squaramide/DBU
sequential
catalytic
strategy
for
the
enantioselective
synthesis
of
nonfused
eight-membered
O-heterocycles
through
asymmetric
addition
ynones
to
β,γ-unsaturated
α-ketoesters
followed
by
regio-
and
diastereoselective
cyclization
adduct
intermediates.
Mechanistic
experiments
revealed
that
an
isomerization
process
should
be
involved
in
ring
formation
step,
origin
high
regioselectivity
diastereoselectivity
has
also
been
elucidated
DFT
calculations.
Язык: Английский