Emerging Advances of the Radical Pathway Glycosylation Enabled by Bench‐Stable Glycosyl Donors: Glycosyl Sulfoxides, Glycosyl Sulfones, and Glycosyl Sulfinates
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(19), С. 4017 - 4041
Опубликована: Июль 30, 2024
Abstract
In
synthetic
carbohydrate
chemistry,
the
modification
of
glycosyl
radicals
pathway
stands
as
a
central
area
focus.
The
radical‐based
reactions
often
demonstrate
remarkable
compatibility
with
various
functional
groups
owing
to
mild
initiation
conditions.
particular,
identification
novel
radical
precursors,
combined
advanced
reaction
techniques,
has
substantially
broadened
scope
compound
synthesis.
Despite
presence
versatile
donors,
synthesis
noble
donors
is
still
addressed
need
and
challenges
associated
sugar
chemistry.
Currently,
new
class
precursors
been
developed
which
enables
production
C
‐,
S
O
N
‐glycosides
efficiently.
this
light,
we
highlight
strategies
towards
bench‐stable
sulfoxides,
sulphone,
sulfite
that
can
enable
site‐,
regio‐
stereoselective
transformation
protected
or
naked
synthons
in
Here,
review
article
covers
recent
developments
selective
diversification
such
alkylation,
arylation,
alkenylation,
sulfuration,
C−H
activation,
DNA
conjugation
via
along
mechanistic
aspects,
challenges,
future
directions.
Язык: Английский
Organometallic Photocatalyst‐Promoted Synthesis and Modification of Carbohydrates under Photoirradiation
The Chemical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Carbohydrates
are
natural,
renewable,
chemical
compounds
that
play
crucial
roles
in
biological
systems.
Thus,
efficient
and
stereoselective
glycosylation
is
an
urgent
task
for
the
preparation
of
pure
structurally
well-defined
carbohydrates.
Photoredox
catalysis
has
emerged
as
a
powerful
tool
carbohydrate
chemistry,
providing
alternative
addressing
some
challenges
glycochemistry.
Over
last
few
decades,
Ir-
Ru-based
organometallic
photocatalysts
have
attracted
significant
interest
because
their
high
stability,
high-energy
triplet
state,
strong
visible-light
absorption,
long
luminescence
lifetime,
amenability
to
ligand
modification.
This
review
highlights
recent
progress
photocatalyst-promoted
synthesis
modification
carbohydrates
under
photoirradiation,
well
related
benefits
drawbacks.
Язык: Английский