Synthesis and Self‐Assembly of Pore‐Forming Three‐Arm Amphiphilic Block Copolymers
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Abstract
The
synthesis
of
an
amphiphilic
three‐arm
block
copolymer
(AB)
3
‐BCP,
which
consists
poly(methyl
methacrylate)
(PMMA)
and
poly(butyl
(PBMA)
in
the
hydrophobic
inner
block,
is
reported.
hydrophilic
segment
based
on
poly(2‐hydroxyethyl
(PHEMA)
originating
from
2‐(trimethylsiloxyl)ethyl
methacrylate
(HEMA‐TMS).
preparation
carried
out
two
steps
using
a
core‐first
approach.
Using
atom
transfer
radical
polymerization
(ATRP)
as
controlled
technique,
three
‐BPCs
with
HEMA
contents
15
to
38
mol
−1
%
are
prepared,
applying
different
reaction
conditions.
Porous
structures
generated
these
BCPs
by
self‐assembly
nonsolvent‐induced
phase
separation
(SNIPS)
protocol.
Complex
surface
observed
scanning
electron
microscopy
(SEM).
Bulk
morphologies
investigated
for
better
understanding
underlying
self‐assembly.
For
PHEMA‐rich
‐BCPs,
non‐regular
lamellar
microphases
transmission
(TEM)
confirmed
small‐angle
X‐ray
scattering
(SAXS).
porous
their
expected
swelling
characteristics
analyzed
atomic
force
(AFM)
air
water.
Time‐resolved
measurements
water
indicate
rapid
after
immersion
into
bath.
present
study
paves
way
exciting
materials
herein
synthesized
copolymers
useful
applications
absorber
coatings.
Язык: Английский
Poly(HEMA-co-MMA) Hydrogel Scaffold for Tissue Engineering with Controllable Morphology and Mechanical Properties Through Self-Assembly
Polymers,
Год журнала:
2024,
Номер
16(21), С. 3014 - 3014
Опубликована: Окт. 27, 2024
Poly(2-hydroxyethyl
methacrylate)
(PHEMA)
has
been
widely
used
in
medical
materials
for
several
decades.
However,
the
poor
mechanical
properties
of
this
material
have
limited
its
application
field
tissue
engineering.
The
purpose
study
was
to
fabricate
a
scaffold
with
suitable
and
vitro
cell
responses
soft
by
using
poly(HEMA-co-MMA)
various
concentration
ratios
hydroxyethyl
methacrylate
(HEMA)
methyl
(MMA).
To
customize
ratio
HEMA
MMA,
characteristics
fabricated
were
investigated
through
structural
morphology,
FT-IR,
property,
contact
angle
analyses.
Moreover,
observed
according
MMA.
Consequently,
morphologies
pore
sizes
changing
MMA
ratio.
scaffolds
measured
results
as
follows:
compressive
maximum
stress:
254.24–932.42
KPa;
tensile
4.37–30.64
modulus:
16.14–38.80
0.5–2
angle:
36.89–74.74°.
In
terms
response,
adhesion
proliferation
human
dermal
fibroblast
(HDF)
cells
whole
scaffold.
Therefore,
synthetic
hydrogel
enhanced
could
be
easily
use
specific
Язык: Английский