A contemporary overview on quantum dots-based fluorescent biosensors: Exploring synthesis techniques, sensing mechanism and applications
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Год журнала:
2025,
Номер
335, С. 126002 - 126002
Опубликована: Март 7, 2025
Язык: Английский
A Patient-Centered Approach in Sensor Science: Embracing Patient Engagement for Translational Clinical Technologies
ACS Sensors,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
With
the
goal
of
impacting
patient
quality
life
and
outcomes,
sensor
science
offers
significant
potential
to
revolutionize
healthcare
by
providing
advances
in
detection
molecular
biomarkers
for
personalized
clinical
technologies.
The
community
has
achieved
technical
advancements
that
can
impact
diagnostics,
health
monitoring,
disease
treatment;
however,
many
innovations
remain
confined
laboratory,
failing
bridge
translational
gap
between
research
real-world
applications.
This
perspective
presents
a
new
direction
community,
where
development
centers
on
needs
experiences
primary
beneficiaries:
patients.
We
provide
guidelines
resources
researchers
engage
with
patients
early
continuously
throughout
process
inform
specifications
better
align
technologies
needs,
improving
their
adoption
impact.
also
present
examples
implementing
patient-centered
approach
planning
engagement
research.
In
design
impactful
sensors
patients,
must
expand
focus
beyond
embrace
approach,
which
will
likely
lead
opportunities
collaboration
evolution
community.
Язык: Английский
Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
rapid,
sensitive,
and
specific
detection
of
NAD(P)H
in
aqueous
medium
the
mitochondria
living
cells
was
achieved
using
an
iridium-based
AIEgen
probe.
Язык: Английский
Aggregation-induced emission(AIE)for Next-Generation Biosensing and Imaging : A review
Biosensors and Bioelectronics,
Год журнала:
2024,
Номер
271, С. 117067 - 117067
Опубликована: Дек. 14, 2024
Язык: Английский
From Molecule to Aggregate: Understanding AIE through Multiscale Experimental and Computational Techniques
The Journal of Physical Chemistry B,
Год журнала:
2024,
Номер
128(50), С. 12559 - 12570
Опубликована: Дек. 10, 2024
Aggregation-induced
emission
(AIE)
phenomena
have
garnered
significant
attention
due
to
their
applications
in
various
fields,
ranging
from
materials
science
biomedicine.
Despite
substantial
progress,
the
underlying
mechanism
governing
AIE
activity
of
molecules
remains
elusive.
This
study
employs
a
comprehensive
and
multiscale
approach,
combining
experimental
theoretical
methodologies,
discern
determinants
activity.
Our
investigations
involve
synthesizing
four
organic
with
D-π–A-D
architecture,
accompanied
by
quantum
mechanics
(QM)
molecular
dynamics
(MD)
simulations,
providing
deep
understanding
interactions
within
aggregates.
The
symmetry-adapted
perturbation
theory
(SAPT)
calculations
further
corroborate
our
findings,
revealing
clear
correlation
between
type
aggregate
formed.
Specifically,
we
demonstrate
that
AIE-active
exhibit
distinctive
J-type
aggregation
characterized
enhanced
S1
state.
In
contrast,
AIE-inactive
adopt
an
H-type
configuration,
where
state
is
constrained.
addition,
investigated
subcellular
localization
molecules,
lipid
droplets.
findings
contribute
fundamental
provide
insights
into
design
principles
for
potential
advanced
sensing
imaging
technologies.
Язык: Английский