Recent Advances in Green Multi-Component Reactions for Heterocyclic Compound Construction
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
highlights
the
recent
advances
in
multi-component
reactions
for
synthesizing
heterocyclic
compounds
via
green
approaches
including
photoredox
catalysis,
electrochemical
activation,
catalyst-free
methods
and
use
of
water
as
sole
solvent.
Язык: Английский
Photocatalyzed Azidofunctionalization of Alkenes via Radical‐Polar Crossover
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
The
azidofunctionalization
of
alkenes
under
mild
conditions
using
commercially
available
starting
materials
and
easily
accessible
reagents
is
reported
based
on
a
radical-polar
crossover
strategy.
A
broad
range
alkenes,
including
vinyl
arenes,
enamides,
enol
ethers,
sulfides,
dehydroamino
esters,
were
regioselectively
functionalized
with
an
azide
nucleophiles
such
as
azoles,
carboxylic
acids,
alcohols,
phosphoric
oximes,
phenols.
method
led
to
more
efficient
synthesis
1,2-azidofunctionalized
pharmaceutical
intermediates
when
compared
previous
approaches,
resulting
in
both
reduction
step
count
increase
overall
yield.
scope
limitations
these
transformations
further
investigated
through
standard
unbiased
selection
15
substrate
combinations
out
1,175,658
possible
clustering
technique.
Язык: Английский
Photocatalyzed Azidofunctionalization of Alkenes via Radical‐Polar Crossover
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Abstract
The
azidofunctionalization
of
alkenes
under
mild
conditions
using
commercially
available
starting
materials
and
easily
accessible
reagents
is
reported
based
on
a
radical‐polar
crossover
strategy.
A
broad
range
alkenes,
including
vinyl
arenes,
enamides,
enol
ethers,
sulfides,
dehydroamino
esters,
were
regioselectively
functionalized
with
an
azide
nucleophiles
such
as
azoles,
carboxylic
acids,
alcohols,
phosphoric
oximes,
phenols.
method
led
to
more
efficient
synthesis
1,2‐azidofunctionalized
pharmaceutical
intermediates
when
compared
previous
approaches,
resulting
in
both
reduction
step
count
increase
overall
yield.
scope
limitations
these
transformations
further
investigated
through
standard
unbiased
selection
15
substrate
combinations
out
1,175,658
possible
clustering
technique.
Язык: Английский
Visible-Light-Induced NHC-Catalyzed Carboacylation Reaction of Alkenes from Aryl Thianthrenium Salts and Aldehydes
Dong-Sheng Ji,
Youwan Ye,
Peiqin Zhang
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
A
metal-free,
visible-light-induced
NHC-catalyzed
multiple-component
reaction
involving
aldehydes
and
aryl
thianthrenium
salts
for
the
carboacylation
of
alkenes
is
reported.
In
this
reaction,
NHC-activated
afforded
Breslow
intermediates,
which
reduced
generated
radicals.
The
resulting
radicals
underwent
radical
addition
reactions
to
yield
arylacylation
products,
in
presence
iodoalkane,
participated
halogen
atom
transfer
process
generate
alkyl
facilitate
olefin
alkylacylation.
Язык: Английский
Nickel/Photoredox Dual-Catalyzed, Regioselective 1,2-Carboacylation of Alkenes via Synergistic Alkyl and Benzoyl Radical Coupling
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
A
regioselective
1,2-carboacylation
protocol
of
alkenes
via
nickel/photoredox
dual
catalysis
has
been
successfully
developed
under
mild
conditions.
wide
range
alkyl
bromides,
α-oxocarboxylic
acids,
and
styrenes
proved
to
be
compatible
the
optimized
conditions,
affording
corresponding
products
in
up
91%
yields.
Mechanistically,
key
success
this
approach
is
temporal
orchestration
radical
generation:
nickel-catalyzed
halogen
atom
transfer
(XAT)
for
bromides
photoredox-driven
decarboxylation
acids.
Язык: Английский
Recent Progress in Metal-Catalyzed C(sp³)-P Bond Formation
Tetrahedron,
Год журнала:
2024,
Номер
168, С. 134352 - 134352
Опубликована: Ноя. 1, 2024
Язык: Английский
Regio- and Stereoselective β-Sulfonylamination of Alkynes via Photosensitized Bifunctional N–S Bond Homolysis
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Nitrogen
central
radicals
(NCRs)
are
versatile
synthetic
intermediates
for
creating
functional
nitrogen-containing
molecules.
Herein,
a
photosensitized
β-sulfonylamination
of
terminal
alkynes
as
well
acetylene
has
been
established
by
employing
N-sulfonyl
heteroaromatics
bifunctional
reagents
(BFRs)
to
efficiently
deliver
(E)-β-sulfonylvinylamines
with
excellent
regio-
and
stereoselectivities.
Mechanistic
studies
suggest
base-accelerated
energy
transfer
(EnT)
photocatalysis
involving
aromatic
NCR
formation,
radical
addition
alkynes,
sulfonylation
processes.
Язык: Английский
Synthesis of succinyldiamides containing all-quaternary carbon center by photo-induced amidation/smiles rearrangement of alkenes
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
A
novel,
mild,
and
environmentally
friendly
method
was
developed
for
the
synthesis
of
quaternary-carbon-containing
succinyldiamides.
This
found
to
be
compatible
with
many
substrates.
Язык: Английский
Visible-Light Induced and Iron Peroxo-Promoted Radical Difunctionalization of Alkene for the Synthesis of β-Ketosulfone and α-Chloroketone
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
In
this
work,
a
switchable
synthesis
of
β-ketosulfone
and
α-chloroketone
through
radical
difunctionalization
alkenes
is
reported.
The
transformation
works
well
under
iron
peroxo
species/photoredox
dual
catalysis
an
open-flask
atmosphere,
the
reaction
highlighted
with
good
yields
broad
scope.
Mechanism
studies
show
that
initiated
by
formal
[4
+
2]
cyclization
sulfonyl
in
regioselective
manner.
Язык: Английский