Dearomative 1,4-Difunctionalization of Non-Activated Arenes Enabled by Boryl Radical-Mediated Halogen-Atom Transfer
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 1294 - 1304
Опубликована: Янв. 7, 2025
Given
the
widespread
presence
of
spirocyclic
scaffolds
in
natural
products
and
pharmacologically
relevant
synthetic
compounds,
development
efficient
methodologies
for
their
construction
holds
great
importance
medicinal
chemistry
pharmaceutical
research.
In
this
study,
a
general
photochemical
dearomative
spirocyclization
nonactivated
arenes
has
been
established.
The
key
to
method
lies
ability
amine-borane
radicals
activate
aryl
bromides
iodides
via
halogen-atom
transfer,
thereby
allowing
conversion
halides
into
corresponding
subsequent
chemodivergent
transformations.
remarkable
compatibility
versatility
1,4-difunctionalization
is
showed
by
rapid
assembly
structurally
diverse
1,4-cyclohexadiene-based
spirocycles
incorporating
oxindole,
indoline,
or
dihydrobenzofuran
subunits.
Moreover,
potential
utility
protocol
exemplified
formal
total
synthesis
vasopressin
V2
receptor
antagonist
Satavaptan.
Язык: Английский
Photoinduced Cascade Synthesis of Oxindoles and Isoquinolinediones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Herein,
we
developed
alkyl
radical
generation
from
C(sp3)–H
bonds
of
alkanes
via
a
photoinduced
HAT-process
without
employing
an
external
metal,
photocatalyst,
and
organic
peroxide.
The
generated
participates
in
addition
cascade
cyclization
N-arylacrylamides/N-acryloyl
benzamides
to
deliver
structurally
diverse
valuable
functionalized
oxindoles
isoquinolinediones
moderate
good
yields.
Preliminary
mechanistic
studies
indicated
the
aryl
through
homolytic
cleavage
Ar–I
direct
photoexcitation
iodide.
Язык: Английский
Catalytic Construction of C(sp3)‐Ge Bonds: Recent Advances and Future Perspectives
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(22), С. 4618 - 4633
Опубликована: Окт. 16, 2024
Abstract
Germanium
(Ge),
a
congener
of
carbon,
possesses
unique
properties
that
hold
extensive
potential
for
applications
across
multiple
domains.
Recent
years
have
seen
significant
progress
in
the
development
carbon‐germanium
bond
formation
strategies,
particularly
those
more
challenging
C(
sp
3
)−Ge
bonds.
This
review
systematically
summarizes
recent
advances
forming
methodologies,
with
particular
emphasis
on
(1)
versatility
transition‐metals,
including
iron,
nickel,
copper,
rhodium
and
palladium,
as
catalysts
broadening
reaction
scope
controlling
selectivity;
(2)
powerfulness
organic
photocatalysis
achieving
mild
selective
formation,
(3)
sustainability
catalytic
electrosynthesis
facilitating
chemical
oxidant‐/reductant‐
free
conversions.
Additionally,
examples
(4)
non‐catalytic
strategies
are
also
discussed.
The
representative
scopes,
well
mechanistic
proposals,
these
protocols
highlighted.
Through
an
overview
current
state
research,
this
aims
to
offer
insights
into
construction
bonds,
provide
perspectives
future
research
directions
address
challenges.
Язык: Английский
Recent Progress in Metal-Catalyzed C(sp³)-P Bond Formation
Tetrahedron,
Год журнала:
2024,
Номер
168, С. 134352 - 134352
Опубликована: Ноя. 1, 2024
Язык: Английский
Photo- and Electro-chemical Strategies for Indazole Synthesis
Tetrahedron Chem,
Год журнала:
2024,
Номер
unknown, С. 100116 - 100116
Опубликована: Дек. 1, 2024
The
indazole
core
is
prevalently
found
in
the
structures
of
bioactive
molecules,
demonstrating
promising
potential
medicinal
chemistry
and
drug
discovery,
which
therefore
has
attracted
sustained
attention
from
synthetic
community.
Over
recent
decades,
significant
progress
been
achieved
both
organic
photocatalysis
electrosynthesis,
offering
novel
approaches
for
efficient
sustainable
synthesis
various
functionalized
indazoles.
This
mini-review
highlights
emerging
methodological
advancements
photo-/electro-chemical
two
common
forms
indazole,
namely
1H-
2H-indazoles,
are
classified
by
specific
intramolecular
bond
formation
patterns:
(1)
C-C
formation,
(2)
C-N
(3)
N-N
formation.
reaction
conditions,
representative
scopes,
mechanistic
understandings
these
protocols
emphasized,
to
elucidate
advantages
limitations
current
strategies,
with
an
aim
inspire
future
innovations
that
may
address
challenges
modern
synthesis.Graphical
abstractTo
create
your
abstract,
type
over
instructions
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box
below.
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or
abstract
dimensions
should
not
be
changed
altered.
Язык: Английский
Recent Advances in Visible Light Photocatalytic and Transition Metal-Catalyzed Synthesis of Disulfide Compounds
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Reviewing
photocatalytic
and
metal-catalyzed
disulfide
synthesis,
2021–2024,
emphasizes
efficiency,
selectivity,
sustainability
for
drug
material
science.
Язык: Английский