Total Synthesis of (±)-Rhazinilam via Red-Light-Driven Zinc(II)porphyrin-Catalyzed Radical Cyclization of N-Substituted Pyrrole DOI

Yusuke Okanishi,

Yoshitatsu Yotsumoto,

Takehiko Yoshimitsu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

A red-light-driven radical cyclization strategy has been developed for the concise synthesis of (±)-rhazinilam. The transformation, catalyzed by [5,15-bis(pentafluorophenyl)-10,20-diphenylporphinato]zinc(II), enables efficient formation a tetrahydroindolizine core from an N-acyloxyphthalimide-substituted pyrrole, providing key intermediate en route to target alkaloid.

Язык: Английский

Red-shifted photoredox generation and trapping of alkyl radicals towards bioorthogonality DOI Creative Commons

David Montoto,

Uxía Deus-Lorenzo,

María Tomás‐Gamasa

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We report two potentially biocompatible photoredox systems for the activation and coupling of redox-active esters using low-energy light BnNAH as reductant.

Язык: Английский

Процитировано

0
Total Synthesis of (±)-Rhazinilam via Red-Light-Driven Zinc(II)porphyrin-Catalyzed Radical Cyclization of N-Substituted Pyrrole DOI

Yusuke Okanishi,

Yoshitatsu Yotsumoto,

Takehiko Yoshimitsu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

A red-light-driven radical cyclization strategy has been developed for the concise synthesis of (±)-rhazinilam. The transformation, catalyzed by [5,15-bis(pentafluorophenyl)-10,20-diphenylporphinato]zinc(II), enables efficient formation a tetrahydroindolizine core from an N-acyloxyphthalimide-substituted pyrrole, providing key intermediate en route to target alkaloid.

Язык: Английский

Процитировано

0