Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер unknown, С. 100627 - 100627
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Biomedical Materials Research Part A, Год журнала: 2025, Номер 113(1)
Опубликована: Янв. 1, 2025
ABSTRACT In the human body, bioelectric cues are crucial for tissue stimulation and regeneration. Electrical (ES) significantly enhances regeneration of nerves, bones, cardiovascular tissues, wounds. However, use conventional devices with stimulating metal electrodes is invasive requires external batteries. Consequently, electrically active materials excellent biocompatibility have attracted attention their applications in engineering. To fully exploit potential these materials, biocompatibility, operating mechanisms, electrical properties, even biodegradability should be carefully considered. this review, we categorize various biomaterials based on mechanisms generating cues, such as piezoelectric effect, triboelectric others. We also summarize key material including characteristics biodegradability, describe musculoskeletal tissues. The hold great advancing field engineering demonstrated success underscores importance continued research field.
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation
Язык: Английский
Процитировано
1
Med-X, Год журнала: 2025, Номер 3(1)
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
1
Molecular & cellular biomechanics, Год журнала: 2025, Номер 22(1), С. 987 - 987
Опубликована: Янв. 3, 2025
Floor materials have a considerable impact on walking stability, especially in tea spaces where quiet and comfort are crucial. The used an users’ biomechanics, which influences balance, postural overall enjoyment these places. Despite their importance, few studies looked into the biomechanical impacts of floor such environments. purpose this research is to create model assess various surfaces stability space design, with use artificial intelligence (AI) for prediction. A using AI algorithms was simulate movements different materials. predicts friction, surface texture, material hardness. data were acquired motion capture sensor technology; from people like wood, ceramic tiles, tatami mats obtained pre-processed by cleaning, z-score normalization, extracting features Principal Component Analysis (PCA). trained processed Dynamic Grasshopper Optimized Deep Belief Network (DGO-DBN) techniques improve forecast accuracy. results show that wooden more stable than higher risk slips trips. findings highlight necessity appropriate selection planning reduce safety issues. This offers light how analysis, paired AI, might influence better design decisions promote user safety.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
Abstract Bioelectricity plays a pivotal role in human physiology and pathology, particularly within the cardiovascular system. Myocardial ischemia disrupts normal transmission of electrical signals through heart, leading to cardiomyocyte death, ventricular remodeling, ultimately heart failure. Electrical stimulation (ES) has been proven be an effective strategy for treating cardiac diseases. However, invasive electrode implantation unique anatomical position limit clinical application ES therapy. Developing wireless systems that effectively enhance bioelectric propagation activity can significantly advance therapeutic interventions. In this study, lead‐free, biodegradable Food Drug Administration approved poly‐L‐lactic acid piezoelectric nanofiber is designed myocardium under ultrasonic stimulation, thus promoting structural functional recovery tissue murine myocardial infarction model. Further study shows ultrasound‐driven system enhanced mitochondria function angiogenesis vivo vitro experiments. Additionally, regulate intracellular calcium ion concentration cardia contraction rhythm isolated neonatal rat. Collectively, findings offer novel approach treatment diseases potential pacing applications
Язык: Английский
Процитировано
0
Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(12)
Опубликована: Март 21, 2025
Interaction of electric fields with biological cells is indispensable for many physiological processes. Thermal electrical noise in the cellular environment has long been considered as minimum threshold detection signals by cells. However, there compelling experimental evidence that field sensed certain and organisms orders magnitude weaker than thermal limit estimated purely under equilibrium considerations. We resolve this discrepancy proposing a nonequilibrium statistical mechanics model active electromechanical membranes hypothesize role activity modulating can be detected membrane. Active contain proteins use external energy sources to carry out specific functions drive membrane away from equilibrium. The central idea behind our mechanisms, attributed different sources, endow ability sense respond are deemed undetectable based on mechanics. Our capable reproducing data available literature varying activity. Elucidating how matter modulate sensitivity open avenues deeper understanding pathological
Язык: Английский
Процитировано
0
Energy storage materials, Год журнала: 2025, Номер unknown, С. 104120 - 104120
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112096 - 112096
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
A hydrogel with tissue-like softness and ideal biocompatibility has emerged as a promising candidate for bioelectronics, especially in bidirectional bioelectrical transduction communication. Conformal standardized biointerfaces are urgent demand to bridge electronic devices irregular tissue surfaces. Herein, we presented shape-adaptative electroactive tissue-adapted conductivity (≈1.03 S/m) by precisely regulating molecular chains polymer networks of multisource gelatin at the scale. Local amine-carboxylate electrostatic domains formed ion interactions between sodium citrate significantly enhance physiological adaptability regulate biodegradation period. Benefiting from reversible fluid-gel transition property, can be situ gelatinized establish dynamic compliance bioelectronic interface tissues chemical bonding physical topological effect. Further, mechanical-electrical coupling capacity allows conduction function reconstruction electrical stimulation therapy after mechanical bridging defects boost regeneration sensory restoration.
Язык: Английский
Процитировано
0
Indus journal of bioscience research., Год журнала: 2025, Номер 3(3), С. 9 - 18
Опубликована: Март 14, 2025
With previously unheard-of improvements in cancer detection, therapy, and monitoring, nano-engineering has become a game-changer precision oncology. Researchers can create nanoscale drug delivery systems that maximize therapeutic efficacy reduce systemic toxicity by utilizing nanotechnology. an emphasis on targeted delivery, tumor microenvironment manipulation, nanocarrier-mediated immunotherapy, this study investigates the molecular processes underlying nano-engineered therapeutics. By increasing specificity lowering side effects, innovations including photothermal photodynamic biomimetic nanostructures, nanoparticle-based CRISPR gene editing are transforming treatment of cancer. Furthermore, real-time, non-invasive detection monitoring made possible liquid biopsy technologies nano-biosensors, allowing for early intervention individualized plans. A comprehensive approach to management is provided interaction nanotechnology oncology, which also makes it easier multipurpose nanoplatforms combine diagnosis (theranostics). Nano-engineering enormous promise overcome resistance, improve immune system engagement, enable precision-targeted treatments as oncology develops. To clinical translation, however, issues biocompatibility, large-scale production, regulatory permissions need be resolved. focus its role developing ground-breaking changing face focuses recent advances, present difficulties, potential future paths therapy.
Язык: Английский
Процитировано
0