Recent advances on electrochemical generation of sulfonyl radical triggered cyclization of alkene/alkynes
Tetrahedron,
Год журнала:
2025,
Номер
173, С. 134467 - 134467
Опубликована: Янв. 12, 2025
Язык: Английский
Flow Electroreductive Nickel‐Catalyzed Cyclopropanation of Alkenes Using gem‐Dichloroalkanes
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Cyclopropanes
are
valuable
motifs
in
organic
synthesis,
widely
featured
pharmaceuticals
and
functional
materials.
Herein,
we
report
an
efficient
electrochemical
methodology
for
the
cyclopropanation
of
alkenes,
leveraging
a
nickel‐catalyzed
process
continuous‐flow.
The
developed
protocol
demonstrates
broad
substrate
scope,
accommodating
both
electron‐rich
electron‐poor
alkenes
with
high
group
tolerance.
Beyond
dichloromethane
as
feedstock
methylene
source,
enables
synthesis
methylated,
deuterated,
chloro‐substituted
cyclopropanes.
Mechanistic
investigations
suggest
electro‐generation
nickel
carbene
key
intermediate.
Notably,
reaction
operates
under
ambient
conditions,
tolerates
air
moisture,
achieves
scalability
through
continuous‐flow
technology,
offering
straightforward
route
to
multi‐gram
quantities
enhanced
throughput.
Язык: Английский
Tunable selective electrochemical selenization of tetrahydroquinolines with diselenides
Green Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
An
electrochemical
method
for
selenylating
tetrahydroquinolines
with
diselenides
is
presented.
By
tuning
reaction
conditions,
C-3
selenylated
quinolines
and
C-6
can
be
selectively
synthesized
excellent
outcomes.
Язык: Английский
A Scalable Flow Electrolysis of Heterogeneous Mixtures Using a Rotating Cylinder Electrode Reactor: Access to a Chiral Iminophosphorane
Organic Process Research & Development,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
We
report
the
application
of
rotating
cylinder
electrode
(RCE)
reactors
for
electrolysis
heterogeneous
reactions
in
batch
and
recirculating
flow.
A
scalable
method
synthesis
an
N-cyano
iminophosphorane
ligand
RCE
reactor
is
also
reported.
In
development
this
process,
a
graphite
felt
attached
to
inner
impervious
was
used
as
anode,
outer
stainless
steel
wall
cathode.
The
reaction
first
evaluated
using
small
optimize
spinning
rate,
supporting
electrolyte,
current
density.
optimal
condition
then
scaled
up
medium-sized
with
modifications
adapt
it
flow
process.
electrosynthesis
demonstrated
100
g
scale,
impact
temperature
investigated.
Finally,
operationally
simple
direct
crystallization
water
antisolvent
provided
chiral
74%
isolated
yield
on
scale
from
commercially
available
(S)-BINAP
bis(trimethylsilyl)carbodiimide.
Язык: Английский
Microfluidic Technology: A New Strategy for Controllable Synthesis of Metal Nanomaterials
ChemElectroChem,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Abstract
Microfluidic
technology
has
exhibited
remarkable
potential
and
significance
in
the
precise
preparation
of
multifunctional
nanomaterials.
Thanks
to
its
small
reaction
volume
superior
hydrodynamic
control,
this
emerged
as
an
essential
tool
for
synthesizing
nanomaterials
with
precisely
tunable
microstructures
morphologies.
This
paper
reviews
latest
advancements
controllable
synthesis
metal
nano‐electrocatalysts
utilizing
microfluidic
technology.
Firstly,
it
systematically
elucidates
fundamental
principles
distinctive
parameter
control
strategies.
Subsequently,
delves
deeply
into
mechanism
enhancement
process
nanoparticles
environment.
Through
analysis
specific
cases,
extensive
application
prospects
advantages
system
have
been
further
elucidated.
Finally,
summarizes
looks
forward
challenges
future
development
directions
that
faces
nano‐electrocatalysts.
review
aims
provide
valuable
insights
morphology
design
technological
innovation
electrocatalysts.
Язык: Английский
Feed and Bleed Operating Mode for Electrochemical Flow Cells: Challenges, Solutions and Practical Insights
ChemElectroChem,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 29, 2025
Abstract
Electrochemical
processes
offer
promising
routes
to
defossilize
the
chemical
industry
by
integrating
low‐carbon
electricity.
However,
bridging
gap
between
lab‐scale
experimental
studies
and
pilot‐scale
industrial
applications
is
still
challenging:
Lab‐scale
electrochemical
flow
cells
typically
operate
in
batch
or
single‐pass
mode,
with
each
mode
facing
limitations
regarding
steady‐state
operation
at
industrially
relevant
conditions.
This
work
introduces
“feed
bleed”
operating
continuous
exchange
of
a
recirculated
electrolyte
stream,
which
enables
versatile
operation.
The
compared
We
develop
mathematical
model
for
validate
experimentally.
Additionally,
this
3D‐printed
phase
separator
coupled
separate
gas
from
liquid
stream.
Batch,
single‐pass,
are
demonstrated
methanol
oxidation
formate
200
mA/cm
2
25
cm
cell.
provides
an
comparison
concerning
product/reactant
concentration,
conversion,
Faraday
efficiency.
highlights
characteristics
electrosynthesis
chemicals,
showcasing
unique
feed
bleed
industrially‐relevant
conditions
high
product
concentration.
Язык: Английский
Electrochemical Access to Difluoromethyl Groups: An Overview of Scope, Mechanisms, and Challenges
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 6826 - 6851
Опубликована: Апрель 14, 2025
Язык: Английский
Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Fluorine
and
nitrogen
form
a
successful
partnership
in
organic
synthesis,
medicinal
chemistry,
material
sciences.
Although
fluorine-nitrogen
chemistry
has
long
rich
history,
this
field
received
increasing
interest
made
remarkable
progress
over
the
past
two
decades,
driven
by
recent
advancements
transition
metal
organocatalysis
photochemistry.
This
review,
emphasizing
contributions
from
2015
to
2023,
aims
update
state
of
art
synthesis
applications
nitrogen-based
organofluorine
functional
molecules
chemistry.
In
dedicated
sections,
we
first
focus
on
fluorine-containing
reagents
organized
according
type
groups
attached
nitrogen,
including
N-F,
N-RF,
N-SRF,
N-ORF.
review
also
covers
nitrogen-linked
building
blocks,
catalysts,
pharmaceuticals,
agrochemicals,
underlining
these
components'
broad
applicability
growing
importance
modern
Язык: Английский
The Future of Electro-organic Synthesis in Drug Discovery and Early Development
ACS Organic & Inorganic Au,
Год журнала:
2024,
Номер
4(6), С. 571 - 578
Опубликована: Ноя. 16, 2024
Electro-organic
chemistry
presents
a
promising
frontier
in
drug
discovery
and
early
development,
facilitating
novel
reactivity
aligned
with
green
principles.
Despite
this,
electrochemistry
is
not
widely
used
as
synthesis
manufacturing
tool
or
development.
This
overview
seeks
to
identify
key
areas
that
require
additional
research
make
synthetic
more
accessible
chemists
development
provide
potential
solutions.
includes
expanding
the
reaction
scope,
simplifying
rapid
scale-up,
developing
electrode
materials,
improving
knowledge
transfer
aid
reproducibility
increase
awareness
of
electrochemistry.
The
integration
electro-organic
into
holds
enable
efficient,
sustainable
routes
toward
future
medicines
faster
than
ever.
Язык: Английский