Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Язык: Английский

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Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Язык: Английский

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Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease

Bioactive Materials, Год журнала: 2024, Номер 46, С. 118 - 133

Опубликована: Дек. 11, 2024

Язык: Английский

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Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Recent investigations have underscored the significant role of manganese ions (Mn2+) in immunization, particularly through activation cGAS-STING pathway, which enhances antitumor immune responses. However, rapid metabolism free Mn2+ following administration limits its effectiveness as an adjuvant. To address these challenges, microneedles (MNs) hyaluronic acid containing Sparfloxacin (SP) and zinc-manganese sulfide (ZMS) are prepared for postoperative situ treatment triple-negative breast cancer (TNBC) to prevent recurrence combat wound infection. ZMS/SP (ZS)-loaded MNs exhibit strong antimicrobial antibiofilm properties that crucial preventing infections. Moreover, generation reactive oxygen species by disrupts oxidative balance, effectively activating immunogenic cell death facilitating release cytokines. ZS significantly suppressed tumor growth, reduced lung metastasis, promoted healing. These effects accompanied notable increases infiltration activation, is consistent with gene sequencing results. Activation pathway further improved immunity. findings highlight potential effective safe utilizes immunostimulatory enhance local systemic responses prevention TNBC metastasis.

Язык: Английский

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Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Bacterial wound infections pose a significant threat to global health, exacerbated by the increase in multidrug-resistant bacteria (MDRB) and formation of elastic biofilms. This review explores transformative potential bioactive materials addressing these challenges, focusing on their design, mechanisms action, therapeutic effects. In vivo, are designed respond unique bacterial microenvironment (BME), utilizing enzyme activity, controlled gas release, surface functionalization, immune regulation combat infections. vitro, this provides comprehensive overview latest advances rational design materials, emphasizing synergistic integration structural modifications (such as size morphology) with external physical stimuli light, sound, electricity, magnetism, force) enhance antibacterial performance. Finally, outstanding challenges prospects rapidly evolving field discussed.

Язык: Английский

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Cu₂O-Based Core–Shell Nanostructures with Glutathione Depletion and O₂ Generation Properties for Photodynamic/Chemodynamic Tumor Therapy

ACS Applied Nano Materials, Год журнала: 2025, Номер 8(2), С. 1284 - 1294

Опубликована: Янв. 8, 2025

Hypoxia and high glutathione (GSH) contents in the tumor microenvironment (TME) diminish efficacy of single-modality photodynamic therapy (PDT) chemodynamic (CDT). Cu2O can effectively release Cu+ within TME, facilitating CDT, concurrently generate O2 to mitigate hypoxia. Co-delivery with photosensitizers (PSs) tumors could potentially enhance PDT/CDT combination therapy. However, challenges such as instability, susceptibility vivo substances affecting catalytic activity, toxicity normal tissues limit utility Cu2O. To overcome these limitations, we propose utilization core GSH-responsive metal–organic framework (MOF) shells, uniformly grown on its surface form Cu2O@MOFs heterostructures. This design prevents leakage deactivation core. We synthesized Cu2+-doped ZIF-67 multifunctional MOF shells situ subsequently incorporated photosensitizer ZnPc into MOFs create Cu2O@Cu2+/ZIF-67@ZnPc (CCZZ). Upon entry cells, this nanodrug degrades presence slight acidity an optimal GSH concentration, releasing while depleting GSH. The released degraded ZIF-67, respectively, Co2+ for CDT O2, consumes PDT under laser irradiation, achieving synergistic best our knowledge, is first study based synthesis Cu2O@Cu-MOFs that achieves dual-enhanced by simultaneously generating oxygen.

Язык: Английский

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Recent Advancements and Future Prospects of Asymmetrically Coordinated Single-Atom Nanozymes with High Enzymatic-like Activity for Biotherapy and Diagnosis: A Review

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Язык: Английский

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Magnetically and optically powered nanozymes: Boosting breast cancer therapy with magnetothermodynamic-enhanced ferroptosis and apoptosis

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161353 - 161353

Опубликована: Март 1, 2025

Язык: Английский

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NIR light activates upconverting nanoparticles/ZnxMn1-xS core-shell nanoparticles for improved breast cancer treatment

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

TUC@ZMS targets cancer cells, depletes GSH, and integrates PDT, CDT, H 2 S gas therapy to eliminate tumors induce ICD, while Mn 2+ activate cGAS-STING, eliciting systemic anti-tumor immunity, curbing tumor growth lung metastasis.

Язык: Английский

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Selective Photothermal Eradication of Glioblastoma Cells Coexisting with Astrocytes by Anti-EGFR-Coated Raman Tags

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Glioblastoma (GBM) is an aggressive and fatal tumor. The infiltrative spread of GBM cells hinders gross total resection. residual are significantly associated with survival recurrence. Therefore, a theranostic method that can enhance the contrast between normal astrocyte (AS) selectively eradicate highly desired. In this report, both cultured in same microplate well to imitate coexistence environment treated Raman tags functionalized by anti-EGFR. Compared AS cells, show 25% higher emission, their cell death rate increases factor 2. These results demonstrate potential for selective eradication guided robust signals after primary surgery.

Язык: Английский

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