Longitudinal Multi-Omics Analysis of the Gut-Liver Axis: Unraveling the Molecular Mechanisms of Metabolic Homeostasis Regulation by Pd@Pt Nanozymes

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101685 - 101685

Опубликована: Март 19, 2025

Язык: Английский

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Fe₃O₄@Bi₂S₃ Nanoparticles Mediated MRI-Guided Precision Radiosensitization for Orthotopic Glioblastoma via External Magnetism

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.

Язык: Английский

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Harnessing Biomaterials to Overcome Challenges in Cancer Immunotherapy

IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 219 - 252

Опубликована: Апрель 25, 2025

The intrinsic immune system activity awakens and trains the patient's to destroy tumor cells. Immunotherapy has become a standard method for treating cancer since it is more potent secure option than conventional therapies like surgery, radiotherapy, chemotherapy. Chimeric antigen receptor-modified T cells, checkpoint blockades, vaccines are three primary forms of immunotherapy that have been developed recently. Chemotherapy, radiation therapy, surgery continue be mainstays treatment despite decades advancements. Lung cancer, melanoma, advanced bladder, kidney, other tumors all successfully treated with immunotherapy. used cure illnesses by regulating an overactive or underactive system. Biomaterials efficiency will increased help engineering targeted drug delivery. Chapter highlights recent advancement in tailored biomaterials

Язык: Английский

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Vanadium nitride quantum dots-based nanozyme in synergy with immune checkpoint blockade for enhanced cancer immunotherapy through vanadate and nitric oxide

Chemical Engineering Journal, Год журнала: 2025, Номер 514, С. 163245 - 163245

Опубликована: Апрель 30, 2025

Язык: Английский

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Stimuli-responsive smart nanomaterials for theranostics of urological cancers

Coordination Chemistry Reviews, Год журнала: 2025, Номер 539, С. 216745 - 216745

Опубликована: Май 1, 2025

Язык: Английский

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