Bioinspired Tough and Antiswelling Hydrogel via in Situ Self-Assembly of Amphiphilic Copolymers within a Hydrophilic Network DOI
Changzhi Xu, Mengyu Li, Yi Wang

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 709 - 715

Опубликована: Май 14, 2025

Inspired by tropoelastin coacervation, a process in elastic fiber formation driven hydrophobic interactions, we developed tough, antiswelling hydrogel, PHEA-(PVA-co-PE), incorporating amphiphilic poly(vinyl alcohol-co-ethylene) (PVA-co-PE) into hydrophilic poly(2-hydroxyethyl acrylate) (PHEA) network. The PHEA-(PVA-co-PE) hydrogel was prepared UV-induced polymerization of PHEA precursor dimethyl sulfoxide (DMSO) solution containing PVA-co-PE, followed immersion water. During solvent exchange, PVA-co-PE self-assembled micellar structures within the matrix, mimicking coacervation tropoelastin. Compared with and hydrogels, strength increased 83 7 times, while toughness 145 97 times. This strategy can be further extended to variety copolymers, demonstrating universality. In vitro vivo tests demonstrated that possesses excellent biocompatibility capability. study provides simple method for developing biocompatible, hydrogel.

Язык: Английский

Complex Dynamics of Nonlinear Oscillations of Hair Bundles of Auditory Hair Cell Regulated by Memristor DOI
Ben Cao,

Kaihua Ma

Опубликована: Апрель 27, 2025

The nonlinear oscillations of hair bundles auditory cell are important for sound perception. Memristors, as electronic components highly similar to the behavior neurons and synapses, show potential in neuromodulation. present paper, first time, introduces memristors into regulation bundle mechanical vibrations, constructs a dynamical model with memristor coupling, investigates regulatory dynamics coupling strength (γ) on oscillation modes through simulation bifurcation analysis. results that γ increases, patterns exhibit variety complex patterns, including different types spiking, bursting, chaos. Bifurcation analysis Lyapunov exponents validate dynamic process mode transitions, indicating influence by regulating adaptation force bundle. Moreover, two-parameter plane indicates increasing can expand region bundle, but excessive suppress oscillations. Under specific parameter combinations, system exhibits insensitivity regulation, reflecting robustness system. This study provides theoretical basis understanding characteristics function developing novel neuromodulation technologies.

Язык: Английский

Процитировано

0
Bioinspired Tough and Antiswelling Hydrogel via in Situ Self-Assembly of Amphiphilic Copolymers within a Hydrophilic Network DOI
Changzhi Xu, Mengyu Li, Yi Wang

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 709 - 715

Опубликована: Май 14, 2025

Inspired by tropoelastin coacervation, a process in elastic fiber formation driven hydrophobic interactions, we developed tough, antiswelling hydrogel, PHEA-(PVA-co-PE), incorporating amphiphilic poly(vinyl alcohol-co-ethylene) (PVA-co-PE) into hydrophilic poly(2-hydroxyethyl acrylate) (PHEA) network. The PHEA-(PVA-co-PE) hydrogel was prepared UV-induced polymerization of PHEA precursor dimethyl sulfoxide (DMSO) solution containing PVA-co-PE, followed immersion water. During solvent exchange, PVA-co-PE self-assembled micellar structures within the matrix, mimicking coacervation tropoelastin. Compared with and hydrogels, strength increased 83 7 times, while toughness 145 97 times. This strategy can be further extended to variety copolymers, demonstrating universality. In vitro vivo tests demonstrated that possesses excellent biocompatibility capability. study provides simple method for developing biocompatible, hydrogel.

Язык: Английский

Процитировано

0