White light increases anticancer effectiveness of iridium(III) complexes toward lung cancer A549 cells
Journal of Inorganic Biochemistry,
Год журнала:
2024,
Номер
259, С. 112652 - 112652
Опубликована: Июнь 26, 2024
Язык: Английский
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
Язык: Английский
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
Язык: Английский
Exploring Excited‐State Intramolecular Proton‐Coupled Electron Transfer in Dinuclear Ir(III)‐Complex via Covalently Tagged Hydroquinone: Phototherapy Through Futile Redox Cycling
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Anticipating
intramolecular
excited-state
proton-coupled
electron
transfer
(PCET)
process
within
dinuclear
Ir2-photocatalytic
system
via
the
covalent
linkage
is
seminal,
yet
challenging.
Indeed,
development
of
various
complexes
also
promising
for
studying
integral
photophysics
and
facilitating
applications
in
catalysis
or
biology.
Herein,
this
study
reports
[Ir2(bis{imidazo-phenanthrolin-2-yl}-hydroquinone)(ppy)4]2+
(12+)
complex
by
leveraging
both
ligand-centered
redox
property
H-bonding
exploring
dual
proton-transfer
assisted
PCET
process.
The
vital
role
covalently
placed
hydroquinone
bridged
ligand
investigated
as
electron-proton
(ET-PT)
mediator
validated
from
triplet
spin
density
plot.
Moreover,
bimolecular
photoinduced
ET
reaction
studied
acetonitrile/water
medium,
forging
lowest
energy
charge
separated
(3CSPhen-Im)
state
12+
with
methyl
viologen
favorably
concerted-PCET
pathway.
result
indicates
strong
donor-acceptors
coupling,
which
limits
recombination
enhances
catalytic
efficiency.
To
showcase
potential
application,
bioinspired
PCET-based
photocatalytic
platform
phototherapeutics,
indicating
significant
mitochondrial
localization
leading
to
programmed
cell
death
(apoptosis)
through
futile
cycling.
consequences
effective
internalization
(via
energy-dependent
endocytosis),
better
safety
profile,
higher
antiproliferative
activity
compared
Cisplatin,
explored
3D
tumor
spheroids,
anticipates
it
be
a
lead
compound.
Язык: Английский