Dihydromyricetin ameliorates hyperuricemia through inhibiting uric acid reabsorption DOI
Ze‐Rui Sun, H. Peng,

Mao‐Si Fan

и другие.

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract BACKGROUND Hyperuricemia (HUA) is a chronic disease caused by abnormal purine metabolism with high prevalence. Dihydromyricetin (DMY) natural flavonoid that abundant in plants, such as vine tea, grapes and bayberry. DMY has been shown to possess multiple biological properties, but its anti‐HUA effect remains underexplored. In the present study, regulatory effects of on HUA complications mechanism were investigated. RESULTS (10 20 μmol L −1 ) treatment significantly reduced xanthine oxidase (XOD) expression uric acid (UA) synthesis normal human liver cell strain cells, intraperitoneal administration (100 mg kg also serum UA hepatic XOD mice. After for 12 consecutive days, uricosuric protein, ATP‐binding cassette subfamily G member 2, was upregulated, reabsorption proteins, including urate transporter 1 glucose 9, downregulated, which consistent results monosodium urate‐induced renal tubular epithelial line colon adenocarcinoma models. addition, ameliorated HUA‐induced injury, foot edema induced urate. The nucleotide‐binding oligomerization domain‐like receptor family containing pyrin domain 3 (NLRP3) inflammasome activated mice evidenced upregulation NLRP3, caspase‐1, ACS, TNF‐ α IL‐1 β kidney foot, suppressed treatment. CONCLUSION Collectively, these findings suggested may play important roles experimental HUA. © 2025 Society Chemical Industry.

Язык: Английский

Dietary alpha-lipoic acid alleviates heat stress by modulating insulin-like signaling to maintain homeostasis in C. elegans DOI Creative Commons

Longnong You,

Zirui Huang, Weiming He

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study explores how dietary alpha-lipoic acid (ALA) protects C. elegans under heat stress. ALA enhances thermotolerance by modulating INS-19, upregulating HSF-1 and HLH-30, activating shock proteins, autophagy, mitophagy.

Язык: Английский

Процитировано

0
L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells DOI Creative Commons
Qiong Wu,

Xiaochun Wan,

Dongxu Wang

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105140 - 105140

Опубликована: Апрель 1, 2025

The rising prevalence of heat stress (HS), because global warming, presents a considerable challenge to both human and animal health welfare. L-Theanine (LTA), naturally occurring amino acid, may enhance poultry muscle yield quality, suggesting its potential application in alleviating the negative impacts HS. However, molecular mechanisms through which LTA exerts beneficial effects remain be fully understood. This study explored protective on cultured broiler skeletal cells under oxidative induced by HS, focusing involved. Our findings indicate that treatment with significantly improved cell survival, bolstered activity antioxidant enzymes, decreased reactive oxygen species (ROS) contents diminished malondialdehyde (MDA) levels HS-treated cells. Furthermore, enhanced phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) nuclear factor erythroid 2-related 2 (Nrf2) signaling pathways cells, facilitating mitochondrial biogenesis reducing apoptosis. were reduced PI3K inhibitor LY294002 or Nrf2 ML385. In conclusion, our showed protects from HS-induced damage modulating PI3K/AKT/Nrf2 pathway, positioning as promising natural for feed additives aimed at improving health.

Язык: Английский

Процитировано

0
Dihydromyricetin ameliorates hyperuricemia through inhibiting uric acid reabsorption DOI
Ze‐Rui Sun, H. Peng,

Mao‐Si Fan

и другие.

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract BACKGROUND Hyperuricemia (HUA) is a chronic disease caused by abnormal purine metabolism with high prevalence. Dihydromyricetin (DMY) natural flavonoid that abundant in plants, such as vine tea, grapes and bayberry. DMY has been shown to possess multiple biological properties, but its anti‐HUA effect remains underexplored. In the present study, regulatory effects of on HUA complications mechanism were investigated. RESULTS (10 20 μmol L −1 ) treatment significantly reduced xanthine oxidase (XOD) expression uric acid (UA) synthesis normal human liver cell strain cells, intraperitoneal administration (100 mg kg also serum UA hepatic XOD mice. After for 12 consecutive days, uricosuric protein, ATP‐binding cassette subfamily G member 2, was upregulated, reabsorption proteins, including urate transporter 1 glucose 9, downregulated, which consistent results monosodium urate‐induced renal tubular epithelial line colon adenocarcinoma models. addition, ameliorated HUA‐induced injury, foot edema induced urate. The nucleotide‐binding oligomerization domain‐like receptor family containing pyrin domain 3 (NLRP3) inflammasome activated mice evidenced upregulation NLRP3, caspase‐1, ACS, TNF‐ α IL‐1 β kidney foot, suppressed treatment. CONCLUSION Collectively, these findings suggested may play important roles experimental HUA. © 2025 Society Chemical Industry.

Язык: Английский

Процитировано

0