MOMAST® Downregulates AQP3 Expression and Function in Human Colon Cells DOI Creative Commons

Ines Angelini,

Mariangela Centrone, Giusy Rita Caponio

и другие.

Antioxidants, Год журнала: 2024, Номер 14(1), С. 26 - 26

Опубликована: Дек. 28, 2024

The water channel AQP3 is an aquaglyceroporin expressed in villus epithelial cells, and it plays a role transport across human colonic surface cells. Beyond water, can mediate glycerol H2O2 transport. Abnormal expression function of have been found various diseases often characterized by altered cell growth proliferation. Here, the beneficial effects MOMAST® evaluated. antioxidant-patented natural phenolic complex obtained from olive wastewater (OWW) Coratina cultivar. Treatment colon HCT8 cells with reduced viability. Confocal studies Western Blotting analysis demonstrated that treatment significantly decreased staining AQP3. Importantly, functional revealed reduction abundance correlates significant decrease uptake. Indeed, was partially but presence or DFP00173, selective inhibitor In addition, MOMAST®-induced associated epithelial-mesenchymal transition (EMT)-related proteins such as vimentin β-catenin. Together, these findings propose potential adjuvant abnormal targeting

Язык: Английский

Incorporating Fresh Durum Wheat Semolina Pasta Fortified with Cardoncello (Pleurotus eryngii) Mushroom Powder as a Mediterranean Diet Staple DOI Creative Commons
Maria Calasso,

Antonino De Lisi,

Arianna Ressa

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 284 - 284

Опубликована: Фев. 27, 2025

Pasta made from durum wheat semolina has a medium-high glycemic index score, high starch digestibility, and limited nutritional value due to its low fiber, vitamin, bioactive compound content. This study aimed enhance pasta's functional qualities by incorporating Pleurotus eryngii (PE) powder at various substitution levels achieve one claim least. research involved two phases: evaluating the chemical/physical, nutritional, functional, sensory properties of laboratory-scale samples validating selected formulations through industrial-scale production shelf-life analyses. The pasta sample with 8.62% PE (SPE8-P) demonstrated significantly improved qualities, including fiber content sufficient for "high content" claim, potential prebiotic activity indicated increased bifidobacterial density during simulated fecal microbiota fermentation. Despite enhanced riboflavin antioxidant content, regulatory constraints inclusion claims vitamin B2 richness activity. Although affecting color, taste, odor profiles, analysis revealed overall acceptability, supporting product's consumer acceptance. confirms feasibility producing innovative, nutritionally enriched as ingredient. Future will focus on in vivo evaluation establish classifying this prototype food.

Язык: Английский

Процитировано

0

Antioxidant Activity and Anti-Inflammatory Effect of Blood Orange By-Products in Treated HT-29 and Caco-2 Colorectal Cancer Cell Lines DOI Creative Commons
Rosa Calvello, Giusy Rita Caponio, Antonia Cianciulli

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 356 - 356

Опубликована: Март 18, 2025

Blood orange peel flour (BO-pf)-a by-product of the citrus supply chain-still contains bioactive molecules with known health benefits, such as antiradical scavenging activity or an antiproliferative regarding tumors. In vitro studies have demonstrated that polyphenols showed potential involvement in necroptosis. addition to previous research, we tested BO-pf on two colorectal cancer cell lines. Using HT29 and Caco2 cells, our experiments confirmed regulation inflammasome expression. They provided valuable insights into how influences features (i.e., viability, proliferation, pro- anti-inflammatory activity). Notably, extract is a rich source polyphenolic compounds antioxidant properties. Western blot real-time PCR analyses treatment beneficial effects by influencing expression both pro-inflammatory cytokines (IL-1β, IL-6) through modulation TLR4/NF-kB/NLRP3 signaling. Moreover, results this study demonstrate extracts can enhance cytokines, IL-10 TGFβ, suggesting may represent promising functional ingredient counteract intestinal inflammatory responses involved IBD.

Язык: Английский

Процитировано

0

Development of functional muffins enriched with lemon by-products as sources of Bioactive compounds DOI
Ana Rita Soares Mateus, Angelina Pena, A. Sanches‐Silva

и другие.

Food Chemistry Advances, Год журнала: 2025, Номер 7, С. 100972 - 100972

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0

Impact of Functional Supplement Based on Cornelian Cherry (Cornus mas L.) Juice in Sourdough Bread Making: Evaluation of Nutritional and Quality Aspects DOI Creative Commons
Ioanna Mantzourani,

Maria Daoutidou,

Stavros Plessas

и другие.

Applied Sciences, Год журнала: 2025, Номер 15(8), С. 4283 - 4283

Опубликована: Апрель 13, 2025

The production of functional bread has been great interest lately to the Food Industry. Regarding this, enrichment with natural raw materials rich in phenolic antioxidants, such as fruits, become a new trend. Likewise, aim current study was evaluate novel supplements based on freeze-dried Cornelian cherry juice, both unfermented and fermented by probiotic L. plantarum ATCC 14917, sourdough production. outcome showed that supplement led elevated nutritional features terms its total content (99.5 mg GAE/100 g) antioxidant activity (213 TE/100 g for ABTS 4.7 μmol TE/g DPPH), well reduction phytic acid (93.3%) compared all other samples. In addition, same sample contained higher amounts lactic (2.91 g/Kg bread) acetic (1.23 g/Kg), formic (0.11 n-valeric (0.12 g/Kg) caproic (0.05 acids samples, leading preservation time (13 days) regarding rope mold spoilage. All breads exhibited sensorial characteristics, proving did not affect quality. This is very interesting since powdered have recently endorsed industry enabling technological improvements.

Язык: Английский

Процитировано

0

MOMAST® Downregulates AQP3 Expression and Function in Human Colon Cells DOI Creative Commons

Ines Angelini,

Mariangela Centrone, Giusy Rita Caponio

и другие.

Antioxidants, Год журнала: 2024, Номер 14(1), С. 26 - 26

Опубликована: Дек. 28, 2024

The water channel AQP3 is an aquaglyceroporin expressed in villus epithelial cells, and it plays a role transport across human colonic surface cells. Beyond water, can mediate glycerol H2O2 transport. Abnormal expression function of have been found various diseases often characterized by altered cell growth proliferation. Here, the beneficial effects MOMAST® evaluated. antioxidant-patented natural phenolic complex obtained from olive wastewater (OWW) Coratina cultivar. Treatment colon HCT8 cells with reduced viability. Confocal studies Western Blotting analysis demonstrated that treatment significantly decreased staining AQP3. Importantly, functional revealed reduction abundance correlates significant decrease uptake. Indeed, was partially but presence or DFP00173, selective inhibitor In addition, MOMAST®-induced associated epithelial-mesenchymal transition (EMT)-related proteins such as vimentin β-catenin. Together, these findings propose potential adjuvant abnormal targeting

Язык: Английский

Процитировано

0