Gut microbiota as a new target for hyperuricemia: A perspective from natural plant products
Ling Dong,
Fengying Dong,
Pingping Guo
и другие.
Phytomedicine,
Год журнала:
2025,
Номер
138, С. 156402 - 156402
Опубликована: Янв. 18, 2025
Язык: Английский
Investigating the Modulatory Effects of Pu-erh Tea on Gut Microbiota in Ameliorating Hyperuricemia Induced by Circadian Rhythm Disruption
Food & Function,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
work
investigated
the
modulatory
effects
of
Pu-erh
tea
on
gut
microbiota
in
ameliorating
hyperuricemia
induced
by
circadian
rhythm
disruption.
Язык: Английский
Hyperuricemia insights: Formation, targets and hypouricemic natural products
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 105944 - 105944
Опубликована: Янв. 1, 2025
Язык: Английский
Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Tea
polyphenols
(TPP)
are
key
contributors
to
the
beneficial
health
effects
of
green
tea
and
black
tea.
However,
their
molecular
mechanisms
action
remain
unclear.
This
article
discusses
importance
bioavailability
TPP
in
understanding
consumption.
The
systemic
is
rather
high
for
smaller
catechins,
low
galloyl
very
or
null
oligomers
polymers
from
oxidation-derived
self-assembled
nanomaterials
not
clearly
known.
If
large
weight
cannot
get
into
circulation,
then
biological
activities
derived
studies
vitro
unlikely
be
relevant
actions
internal
organs
vivo.
In
that
case,
interactions
with
microbiota
on
epithelial
cells
gastrointestinal
tract
important
effects.
Therefore,
different
types
an
factor
determining
Язык: Английский
Identifying meteorological factors influencing catechin biosynthesis and optimizing cultivation conditions of tea plant (Camellia sinensis)
Marat Tukhvatshin,
Qiu-Fa Peng,
Xuan Zhao
и другие.
Frontiers in Plant Science,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 20, 2025
Catechins,
the
most
important
bioactive
components
in
tea
plants
(Camellia
sinensis),
are
influenced
by
growth
environment.
To
identify
and
optimize
key
meteorological
factors
affecting
catechin
accumulation,
we
investigated
relationship
between
plant
biosynthesis
across
three
growing
seasons
at
10
locations.
Rainfall,
average
temperature,
effective
accumulated
temperature
(EAT)
were
identified
as
drivers
regulating
accumulation
via
responsive
expression
of
structural
genes
CsCHS1,
CsANR,
CsSCPL.
Optimal
conditions
for
enhancing
total
esterified
catechins
(TEC)
non-esterified
(TNEC)
determined
using
LINGO
software,
although
optimal
these
two
groups
contrasting.
Hot
rainy
environments
promote
EGCG,
ECG,
TEC
through
CsPAL
CsSCPL,
while
reduced
rainfall
EAT
C,
EGC,
TNEC.
This
study
reveals
differential
effects
on
obtains
promoting
accumulation.
These
results
provide
guidance
improving
cultivation
management.
Язык: Английский
Metabolomic and Cellular Mechanisms of Drug‐Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Certain
medications,
including
cisplatin
and
neomycin,
often
cause
both
hearing
loss
renal
dysfunction.
This
study
aims
to
uncover
the
common
mechanisms
behind
drug-induced
ototoxicity
nephrotoxicity
aid
early
diagnosis
treatment.
Metabolomic
analyses
reveal
simultaneous
disruptions
in
endogenous
metabolic
networks
kidney,
inner
ear,
serum
after
administrating
or
neomycin.
Notably,
a
marked
elevation
uric
acid
(UA),
recognized
indicator
of
tubular
injury,
is
identified.
Supplementing
UA
inhibiting
its
excretion
worsen
hair
cell
damage.
Single-cell
nucleus
sequencing
immunohistochemistry
major
changes
xanthine
oxidase
ABCG2,
crucial
for
metabolism,
primarily
cochlear
stria
vascularis
cells
rather
than
cells.
Cisplatin
triggers
significant
release
from
cells,
reaching
concentrations
sufficient
induce
autophagy-dependent
ferroptosis
In
coculture
system,
targeted
interventions
against
these
two
proteins
through
either
pharmacological
inhibition
genetic
manipulation,
markedly
decrease
elevated
subsequent
These
findings
suggest
connection
between
ear
highlighting
therapeutic
potential
modulating
mitigate
ototoxicity.
Язык: Английский
Fucoidan dose-dependently alleviated hyperuricemia and modulated gut microbiota in mice
Food & medicine homology.,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
The human gut microbiota and uric acid metabolism: genes, metabolites, and diet
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Март 11, 2025
Hyperuricemia
(HUA),
characterized
by
an
excessive
production
of
uric
acid
(UA),
poses
a
significant
risk
for
various
metabolic
disorders
and
affects
over
one
billion
individuals
globally.
The
intricate
interplay
between
the
gut
microbiota
dietary
constituents
plays
pivotal
role
in
maintaining
UA
homeostasis.
Abnormal
consumption
specific
components
such
as
purines,
fructose,
or
aberrant
expression
urate
transporters
can
disrupt
balance,
precipitating
HUA
gout.
exerts
profound
influence
human
regulation,
particularly
presence
gene
clusters.
Individuals
with
often
exhibit
dysbiosis,
reduction
bacteria
producing
short-chain
fatty
acids
those
capable
degrading
UA,
alongside
increase
opportunistic
pathogens.
Dietary
their
microbial
metabolites
engage
interactions
to
modulate
HUA,
regulating
inflammatory
responses,
suppressing
xanthine
oxidase
activity
curtail
production,
enhancing
excretion
via
transporters.
This
comprehensive
review
delineates
factors
metabolism
elucidating
underlying
mechanisms
regulation.
By
unraveling
connections
metabolism,
it
offers
valuable
guidance
grappling
HUA.
Язык: Английский