Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling DOI
Zhaoyan Chen,

Fei Ruan,

Di Wu

и другие.

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Язык: Английский

Understanding of Alzheimer's Disease Pathophysiology for Therapeutic Implications of Natural Products as Neuroprotective Agents DOI

Sneh Prabha,

Arunabh Choudhury,

Asimul Islam

и другие.

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102680 - 102680

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Intranasal amyloid model of Alzheimer’s disease - potential opportunities and challenges DOI
Rakesh Kumar Singh

Pharmacological Reports, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

0
IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer’s Disease DOI
Avtar Singh Gautam, Shivam Kumar Pandey,

Sneha Balki

и другие.

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

0
Betulinic acid protects against lipopolysaccharide and ferrous sulfate-induced oxidative stress, ferroptosis, apoptosis, and neuroinflammation signaling relevant to Parkinson's Disease DOI
Shivam Kumar Pandey,

Anjuman Nanda,

Avtar Singh Gautam

и другие.

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
IL-17A-Induced Redox Imbalance and Inflammatory Responses in Mice Lung via Act1-TRAF6-IKBα Signaling Pathway: Implications for Lung Disease Pathogenesis DOI

Ekta Swarnamayee Panda,

Avtar Singh Gautam, Shivam Kumar Pandey

и другие.

Inflammation, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

1
How do natural products work for Alzheimer’s disease management? DOI
Saheb Ali,

Lekha Sree Venkatesan

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 2

Опубликована: Окт. 14, 2024

Язык: Английский

Процитировано

0
New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment DOI Creative Commons
Violina T. Angelova, Boris Petrov Stoyanov, Rumyana Simeonova

и другие.

Molecules, Год журнала: 2024, Номер 29(22), С. 5314 - 5314

Опубликована: Ноя. 11, 2024

Alzheimer's disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and microglia-mediated neuroinflammation. Current treatments, which generally target single subpathology, have failed to modify the disease's progression, providing only temporary symptom relief. Multi-target drugs (MTDs) address several aggregation of pathological proteins. In this review, we cover hybrid molecules published between 2014 2024. We offer an overview strategies employed in drug design approaches that led notable improvements reduced hepatotoxicity. Our aim is insights into potential development new drugs. This highlights multi-target featuring heterocycles

Язык: Английский

Процитировано

0
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling DOI
Zhaoyan Chen,

Fei Ruan,

Di Wu

и другие.

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Язык: Английский

Процитировано

0